Helicobacter pylori is a gram-negative, curved, microaerophilic organism that has been implicated in the aetiology of gastritis, in the process of gastric and duodenal ulcer formation, and in gastric cancer (15,17). Approximately 10% of individuals are affected by gastritis and/or gastric ulcer during their lifetime and over 50% of the world's population carries this infection (7). The prevalence of gastric H. pylori infection depends on age and varies strongly between developing and developed countries, and according to ethnicity, place of birth and socioeconomic factors among people living in the same country Background/aims: Helicobacter pylori plays a significant role in gastric disease. However, the presence of this bacterium in the oral cavity remains controversial. The aim of the present study was to detect and quantify H. pylori in 29 different sites of the oral cavity in non-dyspeptic subjects by means of real-time polymerase chain reactions (PCR). Methods: Ten subjects without gastric symptoms were studied. Samples from unstimulated saliva, three sites of the tongue, oral mucosa, and 12 sites of both supragingival and subgingival plaque were collected from each subject. DNA was extracted from the oral samples and analysed for the presence of H. pylori by real-time PCR (LightCycler Ò ) using JW23/22 primers which targeted the 16S rRNA gene. DNA from H. pylori DSM 4867 was used as a positive control. Relative quantification with external standards was performed by calculating the target to reference ratio. Results: Amplification efficiency for the LightCycler Ò 2.0 runs ranged from 1.8 to 2.4. Melting curve analysis identified all the positive control capillaries, which contained H. pylori reference DNA, as a single and narrow peak at a melting temperature between 84.5 and 84.9°C. All the negative control capillaries with no template control and the 29 oral samples from each subject showed either no melting peaks or broad melting peaks below 80°C, which were considered as primer dimers. Therefore, H. pylori was not detected from any of the 290 oral samples. Conclusion: Helicobacter pylori seems not to be permanently present in the oral cavity of a non-dyspeptic population.
Uterine rupture is a public health problem in developing countries. When it is spontaneous, it occurs most often during labor in a context of scarred uterus. Uterine rupture during pregnancy is a rare situation. The diagnosis is not always obvious and morbidity and maternal and fetal mortality is still high. We report a case of spontaneous uterine rupture during pregnancy at 35 weeks of an unscarred uterus before labour. This is an exceptional case that we observe for the first time in our unit.
Introduction To investigate the clinical characteristics of COVID-19 in pregnancy in Senegal. Methods This was a cross-sectional and descriptive study of all cases of COVID-19 including nine pregnant women who were admitted in COVID-19 treatment centers in Senegal from March 2 to May 15, 2020. SARS-COV-2 infection was confirmed by PCR. Patients’ characteristics, clinical features, treatment and outcome were obtained with a customized data collection form. Results The frequency of the association COVID-19 and pregnancy was 0.5%. The age range of the patients was 18-42 years with an average 28 years, and the range of gestational weeks at admission was 7 weeks to 32 weeks. None of the patients had underlying diseases. All the patients presented with a headache and only four of them had fever. Other symptoms were also observed: two patients had a cough, two had rhinorrhea, and two patients reported poor appetite. The median time to recovery was 13.6 days, corresponding to the number of days in hospital. None of the nine pregnant women developed severe COVID-19 pneumonia or died. Conclusion Pregnant women appear to have the same contamination predispositions and clinical features of SARS-COV-2 infection as the general population. This study shows no evidence that pregnant women are more susceptible to infection with coronavirus.
IntroductionL'objectif de cette étude etait d'apprécier les caractéristiques épidémiologiques et cliniques de l’éclampsie et d’évaluer la prise en charge et le pronostic maternel et périnatal.MéthodesÉtude descriptive rétrospective sur 3 années (2007-2010) dans un service de Gynécologie Obstétrique de Dakar (Sénégal). Le critère d'inclusion était toute crise convulsive en période gravido-puerpérale dans un contexte de prééclampsie.RésultatsSur un total de 4587 accouchements, 62 cas d’éclampsie étaient enregistrés représentant une incidence de 1,35%. Le profil retrouvé était celui d'une jeune femme (24 ans), primipare (58.1%), habitant la banlieue dakaroise (83.8%), porteuse d'une grossesse à terme (56.5%), mal suivie (82.3%) et référée par un poste de santé environnant (82.3%). La crise était survenue en antépartum et en post-partum dans 72.5 et 27,5% respectivement. Toutes les patientes présentaient une HTA ; l’‘dème et la protéinurie étaient retrouvés dans 72.5 et 84% respectivement. La majorité des patientes (88%) avait présenté plus de deux crises et l’état de mal éclamptique concernait 14.5% des cas. Le sulfate de magnésium était utilisé chez toutes les patientes. La césarienne était le mode d'accouchement largement adopté (75.5%) pour les patientes reçues en antépartum. Le pronostic maternel était marqué par un cas de décès. La mortalité périnatale était de 130%.ConclusionL’éclampsie est un problème de santé publique dans les pays en développement. Les principaux facteurs de risque sont la primiparité et l’âge jeûne. L'administration du sulfate de magnésium et la césarienne permettent d'améliorer le pronostic maternel et foetal. La prévention passe nécessairement par un suivi prénatal de qualité.
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