Prostaglandins for prevention of postpartum haemorrhage

Am, Gülmezoğlu; Forna, Fatu; Villar, José; Hofmeyr, G Justus

doi:10.1002/14651858.cd000494.pub2

Cited by 88 publications

(79 citation statements)

References 48 publications

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“…[7][8][9] In this study, 600 mcg oral misoprostol was compared with 10 unit IM oxytocin for AMTSL and this dose of misoprostol is recommended by WHO for AMTSL when standard oxytocin is not available. This study found that there was no statistical significance between the effectiveness of these drugs in AMTSL and same result was shown by Oboro et al 10 in Nigeria which concluded that oral misoprostol 600 mcg can replace 10 unit intramuscular oxytocin in reducing postpartum hemorrhage in low-risk women, in developing countries. Several other routes of misoprostol like sublingual, vaginal, rectal and buccal have been compared and different doses ranging from 400 to 1000 mcg have been tried in AMTSL.…”

Section: Discussionsupporting

confidence: 56%

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Comparison of Oral Misoprostol with Intramuscular Oxytocin in the Active Management of Third Stage of Labour

Kaudel

Rana

Ojha

2015

Nepal j. obstet. gynaecol.

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Aims:This study aimed at comparing the efficacy of oral misoprostol 600 mcg with intramuscular oxytocin 10 IU in the active management of third stage of labour.Methods: This prospective comparative study was performed in Tribhuvan University Teaching Hospital to compare the efficacy of oral misoprostol with intramuscular oxytocin in the third stage of labour for the prevention of postpartum hemorrhage. One hundred and twenty women without risk of PPH were randomly allocated to receive either 600 mcg misoprostol orally (Group A) or 10 unit of oxytocin intramuscularly (Group B) within 1 minute of delivery. The efficacy and the safety of these two drugs were analyzed on the basis of percentages fall in hemoglobin (Hb) and hematocrit (Hct) level from before delivery to 8 completed hours after delivery, need for additional uterotonic agents, need for exploration and uterine evacuation, need for blood transfusion, duration of third stage of labour and the numbers of retained placenta and need for MRP. Results:Oral misoprostol was observed to be equally effective as intramuscular oxytocin in prevention of post-partum hemorrhage (PPH). There was no statistical difference in the duration of third stage of labour, need for additional uterotonics, need for uterine exploration/evacuation and need for blood transfusion in the two groups.Conclusions: Routine use of oral misoprostol 600 mcg appears to be as effective as 10 IU intramuscular oxytocin in minimizing blood loss during the third stage of labour.Keywords: active management of third stage of labour; misoprostol; oxytocin.

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Section: Discussionsupporting

confidence: 56%

“…Among them 120 women (4.6%) were enrolled in the study. Later 12 of them were excluded because of instrumental delivery (10) and caesarean section (2). Finally 108 women, 54 in each group Group A (600 mcg oral misoprostol) and Group B (10 U intramuscular oxytocin) were studied.…”

Section: Methodsmentioning

confidence: 99%

Comparison of Oral Misoprostol with Intramuscular Oxytocin in the Active Management of Third Stage of Labour

Kaudel

Rana

Ojha

2015

Nepal j. obstet. gynaecol.

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“…However the average blood loss, drop in haemoglobin concentration levels in both study groups were not statistically significant. This is similar to previous studies (12)(13)(14)(15)(16)(17)(18)(19).…”

Section: Discussionsupporting

confidence: 93%

MISOP ROSTOL : AN ALTERNATIVE TO OXYTOCIN IN MANAGEMENT OF 3 rd STAGE OF LABOUR IN RURAL INDIA??

yadav¹,

gaur²,

meena³

2017

Int J Recent Sci Res

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ARTICLE INFO ABSTRACTBackground: Postpartum haemorrhage is a life-threatening obstetricemergency that occurs after normal vaginal delivery or caesarean section. Prevention of PPH can be achieved by active management of the third stage of labour in most of the cases. Various uterotonic agents play major role in prevention of PPH. Objective: To compare efficacy of oxytocin 10 IU intramuscular and misoprostol 800µg per rectally in active management of the third stage of labor and determine duration of the third stage of labor, blood loss, effect on haemoglobin of the patient, adverse effects and need for additional uterotonics in both group. Study methods: A prospective observational study was carried out in the Department of Obstetrics and Gynaecology, Kanwatiya Hospital, SMS Medical College, Jaipur(Rajasthan) from December 2016 to February 2017. Active management of 3rd stage of labor was done by using either inj. Oxytocin 10 IU or tab. Misoprostol 800µg as per the group of the patient. Duration of the third stage of labor,the amount of blood loss, the incidenceof postpartum haemorrhage, a drop in haemoglobinconcentration from predelivery to 24 h after delivery and adverse effect of drugs were measured. Results: Demographic characteristics were similar in each treatmentgroup. There was no significant difference between treatment groups in decrease in hemoglobin (oxytocin 0.7 g/dL, misoprostol 0.8 g/dL). Duration of 3 rd stage of labor was slight more with misoprostol group.The significant side effect was shivering and fever, which were more common in the misoprostol group (shiveringmisoprostol 14% vs. oxytocin 5% and (fever -misoprostol 6% vs. oxytocin 1%). Conclusion: Rectal misoprostol 800µg is as effective as 10 IU intramuscular oxytocin in minimizing blood loss in the third stage of labour. Rectal misoprostol has a lower incidence of side effects which are self limiting. This supports the utility of misoprostol as a safe and effective uterotonic for use in the rural and remote areas of developing countries where other pharmacologic agents may be less feasible.

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“…Много внимания в последние годы уделялось приме-нению простагландинов (ПГ) для профилактики кровоте-чения после родов [22,23]. Однако ряд объединенных международных исследований показал, что они не имеют преимуществ перед традиционными утеротониками [24,25].…”

Section: ключевые слова: послеродовые кровотечения профилактика лечunclassified

International experience with pabal (carbetocin) for the prevention and treatment of postpartum hemorrhage

Shakurova¹,

Ivshin²,

Yatsukhno³

et al. 2016

Ross. vestn. akush.-ginekol.

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. ShakUrOVa, Cand. Med. Sci.; a.a. iVShiN, Cand. Med. Sci.; l.V. yaTSUkhNO; i.e. yakOVleVa; a.i. yakOVleVa; P.V. kOlyBiNa republican Perinatal Center, republic of karelia, Petrozavodsk, russiaThe given review paper briefly considers traditional medicamentous methods for the prevention and treatment of postpartum hemorrhage. Primary emphasis is placed on the use of the longacting oxytocin agonist carbetocin (pabal) to prevent postpar tum hemorrhage, after abdominal delivery in particular. analysis of published works has established that carbetocin combines the safety and tolerability of oxytocin and the stable uterotonic effect of ergometrine. at present, carbetocin (pabal) is primarily indicated for the prevention of uterine hypotonicity and atony during cesarean section. The single intravenous administration of 100 µg of carbetocin (pabal) versus placebo or intravenous oxytocin significantly reduces the need for additional uterotonics to maintain adequate uterine tone and to prevent/treat massive hemorrhage after cesarean section. The administration of this drug is noted to be associated with a lower rate of adverse effects. Carbetocin (pabal) has great economic advantages over ocytocin.The authors declare no conflicts of interest.

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Prostaglandins for prevention of postpartum haemorrhage

Cited by 88 publications

References 48 publications

Comparison of Oral Misoprostol with Intramuscular Oxytocin in the Active Management of Third Stage of Labour

Comparison of Oral Misoprostol with Intramuscular Oxytocin in the Active Management of Third Stage of Labour

MISOP ROSTOL : AN ALTERNATIVE TO OXYTOCIN IN MANAGEMENT OF 3 rd STAGE OF LABOUR IN RURAL INDIA??

International experience with pabal (carbetocin) for the prevention and treatment of postpartum hemorrhage

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