The use of medicinal plants as immunostimulants in aquaculture: A review

Hai, Ngo Van

doi:10.1016/j.aquaculture.2015.03.014

Cited by 454 publications

(214 citation statements)

References 100 publications

(216 reference statements)

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“…Medicinal herbs and plants are major source of such molecules (Galina et al 2009, Van Hai 2015; pre-and probiotics (Nayak 2010), vitamins (Ortuño et al 2001, Azad et al 2007, Kiron 2012) and synthetic molecules (Maqsood et al 2009) have also been evaluated for their effects on the immune system. Amongst immune modulating molecules, β-glucan, a linear polysaccharide extracted from the cell wall of yeast, algae and fungi (Dalmo & Bøgwald 2008) stands as a model of pathogen associated molecular pattern (PAMP) molecule, and as such has been widely exploited as additive in fish diets aiming to improve resistance to infection.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory effects of dietary β-glucan in silver catfish (Rhamdia quelen)

Domenico

Canova²,

Soveral³

et al. 2017

Pesq. Vet. Bras.

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RESUMO.-[Efeito imunomodulador da β-glucana usada como aditivo alimentar em jundiás (Rhamdia quelen).]O uso da β-glucana como suplemento alimentar foi avaliado em jundiás. A β-glucana foi adicionada à ração na proporção de 0.01%, e 0.1% e fornecida aos peixes por 21, para avaliar dados hematológicos e parâmetros do sistema imune natural, ou 42 dias, para avaliar ganho de peso e resistência ao desafio com Aeromonas hydrophila. A adição da β-glucana na dieta não afetou o ganho de peso e não induziu alterações hematológicas nem alterações nos níveis de aglutininas e mieloperoxidase sanguínea. No entanto, a atividade hemolítica natural do sistema do complemento foi significativamente maior nos peixes alimentados com β-glucana. Além disso, nos peixes alimentados com β-glucana e desafiados com A. hydrophila, o número de bactérias isoladas do sangue foi significativamente menor, e a sobrevivência ao desafio foi significativamente maior do que nos peixes que não receberam β-glucana. Consequentemente, concluímos que a β-glucana tem potencial imunomodulador quando adicionada à dieta, nas condições experimentais aqui indicadas, e contribui para aumentar imunidade natural e a resistência dos jundiás ao desafio com patógenos específicos. INTRODUCTIONThe occurrence of infectious diseases is one of the major causes of losses in modern aquaculture (Sitjà-Bobadilla The immunomodulatory effects of dietary β-glucan were evaluated in silver catfish. β-glucan was added to the diet (0.01%, and 0.1%) and fed to the fish for 21 days, to evaluate effects on blood and some innate immune parameter, or fed for 42 days, to evaluate growth rate and resistance to challenge with pathogenic Aeromonas hydrophila. We found that adding β-glucan to the diet had no effect on fish growth and no effect on blood cells, or serum bacterial agglutination and serum myeloperoxidase activity. However, fish that received β-glucan in the diet had the natural hemolytic activity of complement significantly higher compared to control fish. Furthermore, fish fed with β-glucan and challenged with A. hydrophila had fewer bacteria in blood and presented a significantly higher survival rate compared to control fish. Thus, we concluded that β-glucan might be explored as feed additive aiming to improve silver catfish innate immunity and resistance to specific pathogen.INDEX TERMS: Silver catfish, Rhamdia quelen, fish, immunostimulants, β-glucan, Aeromonas hydrophila.

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Section: Introductionmentioning

confidence: 99%

Immunomodulatory effects of dietary β-glucan in silver catfish (Rhamdia quelen)

Domenico

Canova²,

Soveral³

et al. 2017

Pesq. Vet. Bras.

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“…V. harveyi is a saprophytic and opportunistic bacterium, living in fish culture environment in normal condition and becomes pathogen in worsening environmental and host condition (Garrity et al 2004). Vibriosis disease occurs in shrimp including in larvae stadia up to adult shrimp (Soto-Rodriguez et al 2012, Munaeni et al 2014, is antibiotic use (Van Hai et al 2015). Medicinal plant is considered to be able to show potential effect on the growth and survival and also has antimicrobial properties on aquatic organism Citarasu 2010).…”

Section: Abstract: Eleutherine Palmifolia Inhibitory Potential Phymentioning

confidence: 99%

In Vitro Phytochemical and Inhibitory Potential Test of Bawang Hutan Bulb Extract (Eleutherine palmifolia) on Vibrio harveyi

et al. 2017

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B (40 mg mL ), C (60 mg mL ), D (80 mg mL ). Hasil uji fitokimia secara kualitatif menunjukkan bahwa ekstrak bawang hutan buton mengandung senyawa flavonoid, tanin, saponin, quinon, steroid dan triterpenoid. Uji daya hambat terbesar terdapat pada perlakuan D, sedangkan daya hambat minimum terdapat pada perlakuan A. Perlakuan terbaik dari uji kultur bersama juga ditemukan pada perlakuan D. Ekstrak bawang hutan buton pada penelitian ini dapat menghambat pertumbuhan V. harveyi.

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“…Most molecules with immune stimulating properties are derived from herbs, roots and microorganisms, mainly bacteria and fungi (Bairwa et al 2012, Maqsood et al 2011, Van Hai 2015. Studies concerning the immunological effect of viral-derived proteins in fish are scarce.…”

Section: Introductionmentioning

confidence: 99%

Inactivated Parapoxvirus ovis as inducer of immunity in silver catfish (Rhamdia quelen)

Pavan

Nied

Noro

et al. 2016

An. Acad. Bras. Ciênc.

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Molecules with immune modulating activity are ubiquitously distributed in nature and their impact on aquaculture has been exploited in order to increase fish resistance to pathogens. Here, we investigated the effect of inactivated Parapoxvirus ovis (iPPVO) on blood cells and innate and acquired immune response of silver catfish (Rhamdia quelen). iPPVO inoculation had no effect on respiratory burst activity; however, following iPPVO inoculation, we observed a significant decrease on circulating monocytes concomitantly with an increased number of heterophilic granulocytes and thrombocytes, which are the main cells involved in innate immunity and provide connection with acquired immunity. Fish inoculated with a combination of bovine serum albumin (BSA) + iPPVO had significantly higher levels of antibodies to BSA compared to fish inoculated with BSA alone, but lower than fish inoculated with BSA + Freund's incomplete adjuvant (FIA). These findings points to the potential usefulness of iPPVO as immunomodulator in fish and instigate further research to identify its component that interact with immune cells and that could be exploited as adjuvants in fish.

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The use of medicinal plants as immunostimulants in aquaculture: A review

Cited by 454 publications

References 100 publications

Immunomodulatory effects of dietary β-glucan in silver catfish (Rhamdia quelen)

Immunomodulatory effects of dietary β-glucan in silver catfish (Rhamdia quelen)

In Vitro Phytochemical and Inhibitory Potential Test of Bawang Hutan Bulb Extract (Eleutherine palmifolia) on Vibrio harveyi

Inactivated Parapoxvirus ovis as inducer of immunity in silver catfish (Rhamdia quelen)

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