“…SII employs three blood cell subtypes (neutrophils, lymphocytes, and platelets), reflecting the balance between inflammation and the immune response to it [ 22 , 23 ]. In cardiac patients, elevated SII was associated with an increased risk of CAD and its greater severity [ 24 , 25 , 26 ], as well as a worse development of collateral circulation in heart muscle [ 27 ] or a higher risk of major adverse cardiovascular events (MACE) in patients with heart failure [ 28 ] after coronary intervention [ 29 , 30 ] or cardiosurgery [ 31 , 32 , 33 , 34 ]. SII was also described as an independent predictor of massive pulmonary embolism [ 35 ], a contrast-induced nephropathy risk factor in patients undergoing coronary angiography [ 36 , 37 ], a risk factor for postoperative and recurrent atrial fibrillation after cardiac surgery [ 38 ], as well as for developing patent systolic dysfunction in postpartum cardiomyopathy [ 39 ].…”