The Association between Serum Vitamin D Concentration and New Inflammatory Biomarkers—Systemic Inflammatory Index (SII) and Systemic Inflammatory Response (SIRI)—In Patients with Ischemic Heart Disease

Dziedzic, Ewelina A.; Gąsior, Jakub S.; Tuzimek, Agnieszka; Dąbrowski, Marek; Jankowski, Piotr

doi:10.3390/nu14194212

Cited by 22 publications

(16 citation statements)

References 116 publications

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“…These observational studies have examined wide age categories, primarily middle-aged individuals, as homogenous groups without the ability to differentiate prognoses for other age classes, such as the current study's 75-year-old participants. [21,[29][30][31][32] In line with other studies, a study revealed that total and differential WBCs underwent significant alterations during childhood, particularly in the early years. Additionally, as compared to EO#, BASO#, and MONO#, LYMPH# and NEUT# showed more clear age-dependent alterations throughout childhood.…”

Section: [28]supporting

confidence: 82%

Aging and Changes in White Blood Cells Count and Immunity: A Systematic Review

Abukanna¹,

AlAnazi²,

AlAnazi³

et al. 2022

Clin Cancer Investig J

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It is unclear why aging causes a drop in lymphoid-biased HSC numbers and a decline in lymphoid progenitor quality. One possibility is that stem and progenitor cells have inherently programmed processes at work, which would imply that these cells have an internal clock that controls their functionality and lifetime. This study aims to summarize current evidence regarding the Effect of aging on White Blood Cells Count and immunity. The PubMed database and EBSCO Information Services were utilised to choose the articles. In our review, all pertinent articles related to our subject and other publications were used. Other articles that have nothing to do with this subject were not included. The group members looked through a certain format in which the data had been extracted. The WBC count merits consideration as a potentially clinically helpful indicator of survival in individuals aged 75 and older, particularly in women. Monocyte count and total white blood cell count both peaked at the 50th and 97.5th quantiles at birth before significantly declining in the first six months of life. A relatively gradual decline persisted until the age of two. Contrary to the tendency for the neutrophil count, the lymphocyte count peaked in early childhood and subsequently fell as people aged. As the immune system is exposed to infections and environmental non-self-antigens more often after early infancy. This pattern appears to represent the development of acquired and adaptive immune responses.

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Section: [28]supporting

confidence: 82%

Aging and Changes in White Blood Cells Count and Immunity: A Systematic Review

Abukanna¹,

AlAnazi²,

AlAnazi³

et al. 2022

Clin Cancer Investig J

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“…Several investigators have also pointed to the reduction of inflammation by VD in COVID-19 infection as the main mechanism of VD action. In addition, other researchers observed that new biomarkers for inflammation such as the systemic inflammatory index and response were negatively associated with VD concentrations (Dziedzic et al 2022 ).…”

Section: Resultsmentioning

confidence: 99%

Pharmacological evaluation of vitamin D in COVID-19 and long COVID-19: recent studies confirm clinical validation and highlight metformin to improve VDR sensitivity and efficacy

Gomaa,

Abdel-Wadood,

Thabet

et al. 2023

Inflammopharmacol

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Nearly four years after its first appearance, and having gone from pandemic to endemic, the SARS-CoV-2 remains out of control globally. The purpose of this study was to evaluate the clinical efficacy of vitamin D (VD) in COVID-19 and long COVID-19, explain the discrepancy in clinical outcomes and highlight the potential impact of metformin on VD efficacy in recent articles. Articles from January 2022 to August 2023 were selected for this review. The objective of this study was achieved by reviewing, analyzing, and discussing articles demonstrating (1) the mechanism of action of VD (2) observational or randomized clinical trials (RCTs) that support or not the beneficial clinical effects of VD in COVID-19 or long COVID. (3) genetic and non-genetic reasons for the variation in the effects of VD. Articles were collected from electronic databases such as PubMed, Scopus, MEDLINE, Google Scholar, Egyptian Knowledge Bank, Science Direct, and Cochrane Database of Systematic Reviews. Twenty three studies conducted in vitro or in animal models indicated that VD may act in COVID-19 through protecting the respiratory system by antimicrobial peptide cathelicidins, reducing lung inflammation, regulating innate and adaptive immune functions and up regulation of autophagy gene activity. Our review identified 58 clinical studies that met the criteria. The number of publications supporting a beneficial clinical activity of VD in treating COVID-19 was 49 (86%), including 12 meta-analyses. Although the total patients included in all articles was 14,071,273, patients included in publications supporting a beneficial role of VD in COVID-19 were 14,029,411 (99.7%). Collectively, extensive observational studies indicated a decisive relationship between low VD levels and the severity of COVID-19 and mortality outcomes. Importantly, evidence from intervention studies has demonstrated the effectiveness of VD supplements in treating COVID-19. Furthermore, the results of 4 observational studies supported the beneficial role of VD in alleviating symptoms of long COVID-19 disease. However, eight RCTs and one meta-analysis of RCTs may contain low-grade evidence against a beneficial role of VD in COVID-19. Twenty-five articles have addressed the association between VDR and DBP genetic polymorphisms and treatment failure of VD in COVID-19. Impaired VDR signaling may underlie the variability of VD effects as non-genetic mechanisms. Interestingly, in recent studies, metformin has a beneficial therapeutic role in COVID-19 and long COVID-19, possibly by improving AMPK signaling of the VDR and enhancing the efficacy of the VD. In conclusion, evidence has been significantly strengthened over the past 18 months, with several meta-analyses and RCTs reporting conclusive beneficial effects of VD supplementation against COVID-19 and highlighting metformin to improve VDR sensitivity and efficacy in treating COVID-19 and long COVID-19.

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“…As emerging biomarkers, the superiority of SII, SIRI and AISI have been identified in numerous diseases, including cancers, cardiovascular diseases, sacroiliitis and diabetic nephropathy [ 9 , 12 , 13 , 18 – 20 ]. Compared to traditional markers of inflammation, the three systemic inflammation markers are more favorable indicators of inflammatory status and have demonstrated superior predictive power and prognostic value in multiple studies [ 21 – 24 ].…”

Section: Discussionmentioning

confidence: 99%

The association between systemic inflammation markers and the prevalence of hypertension

Jin,

Huang,

Hong

et al. 2023

BMC Cardiovasc Disord

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Background We conducted a large-scale epidemiological analysis to investigate the associations between systemic inflammation markers and hypertension prevalence. Our aim is to identify potential biomarkers for early detection of hypertension. Methods A cross-sectional study with 119664 individuals from the National Health and Nutrition Examination Survey was performed. We investigated the associations between three systemic inflammation markers, namely the systemic immune inflammation index (SII), system inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI), and the prevalence of hypertension. Results The prevalence rates of hypertension gradually increased with increasing logSII, logSIRI, and logAISI quartiles. In continuous analyses, each unit increase in logSII, logSIRI, and logAISI was associated with a 20.3%, 20.1%, and 23.7% increased risk of hypertension. Compared to those in the lowest quartiles, the hypertension risks for subjects in the highest logSII, logSIRI, and logAISI quartiles were 1.114-fold,1.143-fold, and 1.186-fold. The restricted cubic splines (RCS) analysis revealed a non-linear relationship between the elevation of systemic inflammation markers and hypertension prevalence. Specifically, a per standard deviation increase in any of these variables is associated with a respective 9%, 16%, and 11% increase in hypertension prevalence. Conclusion Our cross-sectional study reveals significant positive correlations between SII, SIRI, and AISI with the prevalence of hypertension.

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The Association between Serum Vitamin D Concentration and New Inflammatory Biomarkers—Systemic Inflammatory Index (SII) and Systemic Inflammatory Response (SIRI)—In Patients with Ischemic Heart Disease

Cited by 22 publications

References 116 publications

Aging and Changes in White Blood Cells Count and Immunity: A Systematic Review

Aging and Changes in White Blood Cells Count and Immunity: A Systematic Review

Pharmacological evaluation of vitamin D in COVID-19 and long COVID-19: recent studies confirm clinical validation and highlight metformin to improve VDR sensitivity and efficacy

The association between systemic inflammation markers and the prevalence of hypertension

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