The substituted amino group type dependent sensitivity enhancing of cationic phthalocyanine derivatives for photodynamic activity

Photodynamic antimicrobial chemotherapy with cationic phthalocyanines against Escherichia coli planktonic and biofilm cultures

“…The detailed synthesis of the two Pcs used in this study has been published before. 23,27 A brief overview is shown below.…”

“…The nal product quaternized 2(3), 9(10), 16 (17), 23(24)-tetra-(((dimethylamino)methyl)phenoxy)phthalocyaninato-zinc(II) (ZnPc1) was collected by ltration and washed by diethyl ether, ethyl alcohol and acetone successively. 27 As for the synthesis of ZnPc2, 4-((2-(tritylamino)ethylamino) methyl)phenol (compound B 2 ) was rst synthesized from Ntritylethane-1,2-diamine (compound B 1 ). Aer that, B 2 was used to obtain 4-(4-((2-(tritylamino)ethylamino)methyl)phenoxy) phthalonitrile (compound B 3 ) by reacting with 4-nitrophthalonitrile.…”

Anthracene Substituted Co (II) and Cu (II) phthalocyanines; Preparations, Investigation of Catalytical and Electrochemical Behaviors

“…Phthalocyanines (Pcs) have had wide usage in different areas such as press inks, dyes, pigments and laser technology, beginning from their first synthesis early in the last century . Other areas of current interest include applications in liquid crystals, catalysis, dye‐sensitized solar cells, photodynamic therapy (PDT), biomedicine, electronic and optoelectronic devices, chemical sensors, nonlinear optical (NLO) materials …”

Zwitterionic phthalocyanine zinc (II) synthesis, and photodynamic activity comparison with nonionic and cationic phthalocyanine

“…However, comparing to the NI-ZnPc, CA-ZnPc showed stronger fluorescence intensity due to the intramolecular electrons transfer (PET) effect [23,24]. The nitrogen atom on substituent of NIZnPc is close to the Pc ring, and this p-π conjugation system will cause electron cloud density of the ring to enlarge while electron cloud density of nitrogen atom reduces [18]. The fluorescence quantum yields (Φ F ) of three complexes in CH 3 OH were given in Table S1, and the absolute fluorescence quantum yield was measured by using an integrating sphere.…”

“…The photophysical and photochemical properties, including ROS generation, light stability and fluorescence quantum yields, and photobiology properties, including cancer cell uptake and anticancer activity were compared with other two ZnPcs with the same major structure, including non-ionic (2, 9(10), 16(17), 23(24)-tetra-(4-(N-(2-methyls)) phenoxy) phthalocyaninato-zinc(II), NI-ZnPc) and cationic (2, 9(10), 16(17), 23(24)-tetra-(4-(N-(2-methyls)) phenoxy) phthalocyaninato-zinc(II), CA-ZnPc) structures ( Fig. 1), NIZnPc and CA-ZnPc were synthesized according to the literature [18]. All structures of above compounds were characterized by a combination of IR, 1 H NMR, elemental analysis and UV-Vis spectrum.…”