The Study of Breast Milk IGF-1, Leptin, Ghrelin and Adiponectin Levels as Possible Reasons of High Weight Gain in Breast-Fed Infants

Kon, I. Ya.; Шилина, Н. М.; Gmoshinskaya, M.V.; Ivanushkina, T A

doi:10.1159/000367998

Cited by 70 publications

(106 citation statements)

References 26 publications

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“…Andreas et al (43) report of the three studies identified, none found a significant correlation between maternal BMI and breast milk ghrelin levels . An additional study also reported no significant correlation between maternal BMI and ghrelin concentration in breast milk . However, a recent study found an inverse association between maternal BMI and ghrelin concentration in breast milk .…”

Section: Bioactive Components In Breast Milkmentioning

confidence: 97%

A narrative review of the associations between six bioactive components in breast milk and infant adiposity

Fields

Schneider

Pavela

2016

Obesity

104

123

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Objective This narrative review examines six important non-nutritive substances in breastmilk, many of which were thought to have little to no biological significance. The overall objective of this narrative review is to provide background on key bioactive factors in breastmilk believed to have an effect on infant outcomes (growth and body composition). Methods The evidence for the effects of the following six bioactive compounds in breastmilk on infant growth outcomes are reviewed: insulin, leptin, adiponectin, ghrelin, interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α). Results The existing literature on the effects of breastmilk insulin, ghrelin, IL-6 and TNF-α and their associations with infant growth and adiposity is sparse. Of the bioactive compounds reviewed, leptin and adiponectin are the most researched. Data reveals that breastmilk adiponectin has negative associations with growth in infancy. Conclusions There is a need for innovative, well-designed studies to improve causal inference and advance our understanding in the effects of breastmilk and its components on offspring growth and body composition. The recommendations provided, along with careful consideration of both known and unknown factors that affect breastmilk composition, will help improve, standardize and ultimately advance this emergent field.

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Section: Bioactive Components In Breast Milkmentioning

confidence: 97%

A narrative review of the associations between six bioactive components in breast milk and infant adiposity

Fields

Schneider

Pavela

2016

Obesity

104

123

View full text Add to dashboard Cite

show abstract

“…The adipokines phenotype as predictor of early-life weight gain, has been recently explored, both in breast milk and cord blood serum concentrations (7,8,9). Adiponectin and leptin are factors known to influence normal and abnormal fetal growth (10,11,12).…”

Section: Introductionmentioning

confidence: 99%

Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns

Treviño-Garza

Estrada-Zúñiga

Mancillas-Adame

et al. 2016

Jcrpe

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Objective:Most adipose tissue programming is realized in early life. Also, the postnatal three months, rather than the later phases of infancy, may be more relevant in the development of an adverse cardiometabolic risk profile. The adipokines phenotype, as a predictor of early-life weight gain, has been recently explored in cord blood. To determine whether in addition to leptin levels in cord samples, adiponectin, interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), resistin, plasminogen activator inhibitor-1 (PAI-1), and tumor necrosis factor alpha (TNF-α) levels improve weight gain prediction during the first three months of life.Methods:Adiponectin, IL-6, MCP-1, leptin, resistin, PAI-1, and TNF-α were measured by multiplex immunoassay in a subsample of 86 healthy term newborns.Results:Leptin levels significantly predicted weight gain at 3 months of follow-up (r2=0.09, p=0.006). In the multivariate analysis, including additional adipokines in the model, stepwise or all at once, did not increase the prediction of weight gain after the first three months of life.Conclusion:Adding adiponectin, IL-6, MCP-1, resistin, PAI-1, and TNF-α to the prediction model of weight gain in healthy newborns did not prove to be useful. It is probable that their relative contribution to weight gain is not important. Only leptin was relevant as a predictor of weight gain at the 3-month endpoint.

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“…EGF, HB-EGF, Epo, NGF. [26][27][28] At that period, the infant liver is unable to produce IGF-1 and probably the aforementioned other bioactive factors cause the first pathophysiological stage to occur. 35 According to our study results we speculate that; premature infants, who have had the opportunity to receieve human breast milk for enough time, could complete the retinal vascular development and by-pass the first stage of ROP with the help of maternal IGF-1 found in the human breast milk.…”

Section: Volume 61 • Numbermentioning

confidence: 99%

“…35 According to our study results we speculate that; premature infants, who have had the opportunity to receieve human breast milk for enough time, could complete the retinal vascular development and by-pass the first stage of ROP with the help of maternal IGF-1 found in the human breast milk. [26][27][28] Several studies in the literature support this speculation by showing the association between the weight gain (prenatal and postnatal) and retinal vascularization, depending on the effect of IGF-1 by nutritional support. 36,37 This support is human breast milk.…”

Section: Volume 61 • Numbermentioning

confidence: 99%

“…[19][20][21][22][23][24][25] Human breast milk is indispensable for the maturation as it contains many immunogenic factors like epidermal growth factor (EGF), transforming growth factor (TGF) α, β1-2, ghrelin, lectin, adiponectin, erythropoietin and insulin-like growth factor-1(IGF-1). [26][27][28] In order to assess the effect of human milk and to revisit the risk factors related with ROP, the records of our patients were retrospectively analyzed.…”

mentioning

confidence: 99%

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Retinopathy of prematurity risk factors: Does human milk prevent retinopathy of prematurity?

Akyüz-Ünsal¹,

Key²,

Güler³

et al. 2019

Turk J Pediatr

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Akyüz-Ünsal Aİ, Key Ö, Güler D, Bekmez S, Sagus M, Akcan AB, Kurt-Omurlu İ, Anık A, Oruç-Dündar S, Türkmen M. Retinopathy of prematurity risk factors: Does human milk prevent retinopathy of prematurity? Turk J Pediatr 2019; 61: 13-19.The aim of this study was to investigate the risk factors for Retinopathy of Prematurity (ROP) development and the potential effect of human breast milk among these factors. For this purpose, infants admitted to a tertiary referral clinic for ROP screening and treatment between April 2013 and May 2015, were included in this retrospective study. The demographic data, accompanying diseases, previous surgery, type of feeding and duration of human breast milk intake were recorded. According to the ROP screening examination results, infants were divided into two groups as those with ROP (infants at any stage of ROP) and those without ROP. Relationship between the risk factors and ROP were evaluated. The comparison of 221 infants without ROP and 99 infants with ROP; revealed that gestational age at birth, birth weight, mechanical ventilation support, bronchopulmonary and cardiac diseases, hydrocephaly, any previous surgery, infections, steroid treatment percentages were high and human breast milk intake percentage was low among infants with ROP. Mean breast feeding time for infants with ROP (3.81 ± 2.33 month) was shorter than the infants without ROP (5.51 ± 1.43 month) (p<0.001). In logistic regression analysis, the duration of breast feeding was inversely related with ROP (OR 0.744; 95% CI 0.621-0.891; p<0,001). These results suggest that gestational age at birth and accompanying diseases are the main risk factors for the development of ROP. As the duration of the breast feeding of the infants without ROP was longer than the infants with ROP; breast feeding may have a preventive effect on ROP development. : breast feeding, human breast milk, retinopathy of prematurity, risk factors, ROP. Key words

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The Study of Breast Milk IGF-1, Leptin, Ghrelin and Adiponectin Levels as Possible Reasons of High Weight Gain in Breast-Fed Infants

Cited by 70 publications

References 26 publications

A narrative review of the associations between six bioactive components in breast milk and infant adiposity

A narrative review of the associations between six bioactive components in breast milk and infant adiposity

Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns

Retinopathy of prematurity risk factors: Does human milk prevent retinopathy of prematurity?

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