Retinopathy of prematurity risk factors: Does human milk prevent retinopathy of prematurity?

Akyüz-Ünsal, Ayşe İpek; Key, Özge; Güler, Duygu; Bekmez, Sinan; Sagus, Mehtap; Akcan, Abdullah Barış; Kurt-Omurlu, İmran; Anık, Ayşe; Oruç-Dündar, Sema; Türkmen, Münevver

doi:10.24953/turkjped.2019.01.003

Cited by 8 publications

(4 citation statements)

References 32 publications

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“…Human breast milk contains immunogenic factors such as IGF-1 and epidermal growth factor (EGF-1). A shorter duration of breast milk feeding along with premature birth causes deprivation of the maternal immunogenic factors, which effectuates the hypoxic and hyperoxic phase of retinopathy of prematurity [ 22 ]. Twins or multiple births are associated with a higher risk of the baby being born preterm and of small birth weight.…”

Section: Reviewmentioning

confidence: 99%

A Review on the Incidence and Related Risk Factors of Retinopathy of Prematurity Across Various Countries

Nair¹,

Ballushi²,

Anklesaria³

et al. 2022

Cureus

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Retinopathy of prematurity (ROP) is an ophthalmologic condition that is one of the leading causes of preventable childhood blindness. Due to the premature nature of blood vessels in preterm infants, retinal vessels are prone to damage. The incidence of ROP ranges with great variation across countries, and this study aims to identify the incidence and its related risk factors.A compilation of studies investigating the incidence of ROP was acquired through the PubMed and Google Scholar databases with a full free text in English filter set. All members of the study were involved in designating studies based on continent and arranging them into a table format. Following this, reasons for the variation in the incidence of ROP were investigated by individually assessing each study. The variation of an increased incidence of ROP seen in low-income countries (LICs) was most likely due to the availability of resources. As a preterm birth can give rise to further complications such as the development of sepsis, it is important to manage preterm birth with the utmost caution. Evidence has suggested that the two key variables in reducing the morbidity and mortality of ROP are the implementation of a screening and treatment protocol with controlled use of oxygen and the availability of resources in hospitals to adequately identify and manage ROP as early as possible.Through a comprehensive overview of the incidence of ROP, it is vital to review screening and treatment protocols in each hospital for ROP, which would aid in preventing its occurrence and initiating early treatment.

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Section: Reviewmentioning

confidence: 99%

A Review on the Incidence and Related Risk Factors of Retinopathy of Prematurity Across Various Countries

Nair¹,

Ballushi²,

Anklesaria³

et al. 2022

Cureus

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“…5 Multiple studies show that ROP is a multifactorial pathology; among the neonatal risk factors that have been described are low birth weight, gestational age, neonatal sepsis, respiratory distress, hyaline membrane disease, transient tachypnea, bronchopulmonary dysplasia, oxygen therapy, mechanical ventilation, intraventricular hemorrhage, anemia and persistence of the ductus arteriosus. [7][8][9] Identification of risk factors involved in the progression of ROP and a better understanding of their etiology can help ophthalmologists and neonatologists in careful detection, accurate diagnosis and prevention of disease development. 9 Retinopathy of prematurity is generally predictable in nature, sequentially progressive, such that timely treatment has been shown to reduce the risk of visual loss, and effective care with carefully timed indirect ophthalmoscopy examinations to identify the presence of ROP allows for timely treatment.…”

Section: Introductionmentioning

confidence: 99%

Incidence and Risk Factors Associated with Retinopathy of Prematurity in Peru

Carranza-Mendizabal¹,

Diaz-Manrique²,

Mamani

et al. 2021

OPTH

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The purpose of this research is to determine retinopathy of prematurity (ROP) prevalence and possible risk factors associated with ROP development in newborns admitted to a neonatal unit of a Peruvian National Reference Hospital. Patients and Methods: This retrospective study included 216 preterm infants. The data were collected between January 2016 and December 2018. All infants were examined according to Peruvian guidelines for screening and treatment of ROP. The association of clinical risk factors and the development of ROP was analyzed and predictive factors were determined. Results:The study subjects were 216 preterm infants of which 72 had some stage of ROP (32 stage 1; 23 stage 2 and 17 stage 3) and 144 preterm infants without ROP. The incidence of ROP in preterm infants less than 32 weeks was 60.9%, while for those weighing less than 1500 g it was 71.6%. The factors associated with ROP were gestational age below 32 weeks, birth weight below 1500 grams, neonatal sepsis, oxygen therapy, mechanical ventilation, hyaline membrane disease, bronchopulmonary dysplasia, persistence of ductus arteriosus and intraventricular hemorrhage. Exclusive breastfeeding was found to play a protective role against ROP. Binary logistic regression analysis found that only gestational age below 32 weeks (OR, 2.637; 95% CI, 1.04-6.69), weight below 1500 grams (OR, 4.377; 95% CI, 1.75-10.92), neonatal sepsis (OR, 6.517; 95% CI, 2.81-15.14), vaginal delivery (OR, 3.748; 95% CI: 1.54-9.14), and the presence of hyaline membrane disease (OR, 3.58; 95% CI,) are predictors of ROP. Conclusion:The incidence of ROP among very low birth weight infants was 71.6%. Infants with weight below 1500 grams, neonatal sepsis, presence of hyaline membrane disease whose mother had vaginal delivery are at risk for the development of ROP. Thus, preventing premature births and encouraging exclusive breastfeeding are two main ways to prevent ROP.

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“…Several benefits of breastfeeding (BF) are well-established in the literature [1][2][3][4][5][6][7][8][9]. For high-risk newborns (NBs), they range from protection against some diseases to neonatal survival with a higher quality of life [10][11][12][13][14][15][16][17][18][19][20]. Considering that it is an intervention of great impact in the the first consultation after hospital discharge at the follow-up clinic or HMB; (iii) monthly telephone interviews until the sixth month of life (up to ten attempts were made per month to minimize follow-up losses).…”

Section: Introductionmentioning

confidence: 99%

The effect of risk at birth on breastfeeding duration and exclusivity: A cohort study at a Brazilian referral center for high-risk neonates and infants

et al. 2021

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Background and aim Both breastfeeding and the use of human milk are strategies that provide better conformation to health throughout an individual’s life and bring countless short- and long- term benefits, which are well established in the scientific literature. For at-risk newborns (NBs), these strategies are crucial interventions to enable neonatal survival with better quality of life due to the distinctive and complex composition of human milk, which serves as personalized food-medicine-protection. However, there is limited knowledge about breastfeeding practices in high-risk NBs. The aim was to estimate the duration of EBF and to investigate the effect of risk at birth on EBF discontinuity in the first six months of life’. Methods This cohort study included 1,003 NBs from a high-risk referral center, followed up from birth to the sixth month of life, between 2017 and 2018. Correspondence and cluster analysis was used to identify neonatal risk clusters as the main exposure. The object of interest was the time until EBF discontinuity. The Kaplan-Meier methods and the Cox proportional hazards model were used to estimate the hazard ratio and 95% confidence intervals. Results The prevalence and median duration of EBF decreased proportionally in the three groups. The multiple model revealed a gradient in EBF discontinuity, which was 40% higher in risk group 1 and 111% higher in risk group 2 compared to healthy full-term NBs. Additionally, EBF during hospitalization predicted a longer median duration of this practice for high-risk NBs. Conclusion This study confirms a high proportion of high-risk NBs who have EBF discontinued before six months of life. The risk of EBF discontinuity is higher in risk groups, with a gradual effect even when adjusted by several factors. Effective interventions are needed to promote, protect, and support breastfeeding in different profiles of risk-at-birth groups.

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Retinopathy of prematurity risk factors: Does human milk prevent retinopathy of prematurity?

Cited by 8 publications

References 32 publications

A Review on the Incidence and Related Risk Factors of Retinopathy of Prematurity Across Various Countries

A Review on the Incidence and Related Risk Factors of Retinopathy of Prematurity Across Various Countries

Incidence and Risk Factors Associated with Retinopathy of Prematurity in Peru

The effect of risk at birth on breastfeeding duration and exclusivity: A cohort study at a Brazilian referral center for high-risk neonates and infants

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