The scotopic electroretinogram to blue flashes and pattern reversal visual evoked potentials in insulin dependent diabetes

Seeing Beyond Retinopathy in Diabetes: Electrophysiological and Psychophysical Abnormalities and Alterations in Vision

“…No significant differences in flash ERG were demonstrated in the diabetic subjects compared with nondiabetic controls, in contrast to a change in P100 latency that was markedly increased in the diabetic group. By contrast, Papakostopoulos et al (28) reported significant changes in 'b' wave amplitude but, although this group also exhibited significant changes in P100 latency, these two variables did not correlate significantly. Martinelli et al (20) demonstrated lower mean PERG results at all spatial frequencies and contrast levels in a group of subjects with IDDM.…”

“…These alterations, however, were not found by other investigators (22,26). Several studies showed significant reductions in OP amplitude in subjects with background retinopathy (23,28,29). Perhaps the most compelling evidence for any association is provided by the prospective studies by Bresnick and Palta, which followed a group of young IDDM patients over a period of 15 yr (17,29).…”

“…Of the studies assessing only flash ERG, the majority report abnormalities, mainly reduced OP amplitude, in diabetic subjects with no evidence of retinopathy compared with nondiabetic controls (13)(14)(15)(16)(17)(18)(19). Fewer studies have assessed PERG (20 -26), and the results are less conclusive, with some groups reporting abnormalities in the diabetic subjects (20,24,25) in contrast to those who found no difference (21)(22)(23)26 (20,27,28). Uccioli et al (27) examined flash ERG in a group of recently diagnosed patients with IDDM and compared the results with changes in visual evoked potentials (VEPs) (P100; vide infra).…”

Ophthalmic markers of the diabetic polyneuropathy

“…D. Papakostopoulos et al получили данные о снижении амплитуды волны b у пациентов с СД 1-го типа без признаков ДР [40]. M. Di Leо et al, а также S.Caputo et al обнаружили сни-жение амплитуды паттерн-ЭРГ у больных диабе-том без ДР [17,13].…”

“…Однако в последнее время были получены данные, что исследование роговицы (конфокальная микроскопия) может оказать зна-чительную помощь именно в ранней диагностике ДПН, поскольку изменение роговичных нервов может служить маркером нейропатии [30,33,43,54]. Кроме этого, некоторые исследователи стали указывать на то, что ряд изменений сет-чатки, зрительного нерва и зрительных функций может коррелировать с ДПН, а значит, их оценка может дать дополнительную информацию при вы-явлении и определении тяжести полинейропатии [13,17,28,40,48,53,59].…”