The Role of the Pineal Gland in Environmental Adaptation

Quay, W. B.

doi:10.1016/b978-0-08-012023-2.50028-2

Cited by 21 publications

(4 citation statements)

References 228 publications

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“…Most often, and erroneously, relegated to the status of a "functionless vestige of a third eye," in adult mammals it has been revealed in recent decades to be metabolically active, biochemically unique, and structurally possessing characteristics of an endocrine gland.*. 3 Even with the wealth of new descriptive data, disagreement, if not doubt, remains concerning possible functional significance. The physiological relationship imputed most frequently is with the reproductive system.…”

Section: Introductionsupporting

confidence: 67%

Pineal Homeostatic Regulation of Shifts in the Circadian Activity Rhythm During Maturation and Aging†

Quay

1972

Trans NY Acad Sci

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Section: Introductionsupporting

confidence: 67%

Pineal Homeostatic Regulation of Shifts in the Circadian Activity Rhythm During Maturation and Aging†

Quay

1972

Trans NY Acad Sci

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“…of changes observed after pinealectomy is often ignored, misinterpreted or denied. Fragmentary information is available to suggl'st that some effects following surgical pinealectomy can be due not to pineal removal itself, but to other effects of the intracranial surgery (Dill 1961;Kovacs, Vertes, Santior and Vertes 1965;Quay 1969Quay , 1971. The central interest in the present re port is experimental evidence showing a difference between sham-pinealectomy and pinealectomy in the resulting changes over time in hyperglycemia following administration with alloxan.…”

Section: Introductionmentioning

confidence: 95%

Effects of Pinealectomy and of Sham-Pinealectomy on Blood Glucose Levels in the Alloxan-Diabetic Rat

1978

Horm Metab Res

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Alloxan-diabetic male rats were used to test effects of pinealectomy (PX) and of sham-pinealectomy (SPX) on blood glucose levels at mid-dark in the daily light-dark (LD 12:12) cycle. Animals received a diabetogenic dose of alloxan 10 days postoperatively. Blood glucose was measured on days -1,1,2,3,4,5,7,10 and 15 after 8-hour fasts. Pinealectomized (PX) and non-operated (C) animals were equivalent in their hyperglycemia following alloxan. SPX animals contrastingly showed significantly less response to alloxan than did animals of the other two groups. This difference of the SPX animals was in terms of lower hyperglycemia, better maintenance of body weight and of survival. It is concluded that intracranial surgery alone (SPX) and without visible brain damage can affect mechanisms of glucose homeostasis, and that at least in some circumstances such a surgical effect is not only different from effects of surgical pinealectomy (PX), but is also probably not pineal-dependent.

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“…Indeed, pineal glands have been conjectured to be neuroendocrine devices, receiving exogenous and endogenous inputs and having outputs to several peripheral systems (Wurtman & Anton-Tay, 1969). In this context, the pineal organ is thought to be primarily concerned with adaptation to the environment (Quay, 1969).…”

mentioning

confidence: 99%