Pineal Homeostatic Regulation of Shifts in the Circadian Activity Rhythm During Maturation and Aging†

Quay, W. B.

doi:10.1111/j.2164-0947.1972.tb02679.x

Cited by 48 publications

(10 citation statements)

References 26 publications

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“…In humans, melatonin may be effective in alleviating jet lag, improving sleep quality and speeding up the resynchronisation of plasma melatonin and cortisol rhythms (Arendt et al 1986(Arendt et al , 1987. Not only melatonin given at a certain time of day but also pinealectomy (Quay 1970(Quay , 1972Kincl et al 1970;Finkelstein et al 1978) and intrahypothalamic melatonin implants (Murakami et al 1983) may speed up the resynchronisation of the circadian system. The presence or absence of melatonin at a certain phase may apparently play a role in the reentrainment mechanism.…”

Section: Discussionmentioning

confidence: 99%

Melatonin accelerates reentrainment of the circadian rhythm of its own production after an 8-h advance of the light-dark cycle

1989

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The rhythm in melatonin production in the rat is driven by a circadian rhythm in the pineal N-acetyltransferase (NAT) activity. Rats adapted to an artificial lighting regime of 12 h of light and 12 h of darkness per day were exposed to an 8-h advance of the light-dark regime accomplished by the shortening of one dark period; the effect of melatonin, triazolam and fluoxetine, together with 5-hydroxytryptophan, on the reentrainment of the NAT rhythm was studied. In control rats, the NAT rhythm was abolished during the first 3 cycles following the advance shift. It reappeared during the 4th cycle; however, the phase relationship between the evening rise in activity and the morning decline was still compressed. Melatonin accelerated the NAT rhythm reentrainment. In rats treated chronically with melatonin at the new dark onset, the rhythm had already reappeared during the 3rd cycle, in the middle of the advanced night, and during the 4th cycle, the phase relationship between the evening onset and the morning decline of the NAT activity was the same as before the advance shift. In rats treated chronically with melatonin at the old dark onset or in those treated with melatonin 8 h, 5 h and 2 h after the new dark onset during the 1st, 2nd and 3rd cycle, respectively, following the advance shift, the NAT rhythm reappeared during the 3rd cycle as well but in the last third of the advanced night only. Neither triazolam nor fluoxetine together with 5-hydroxytryptophan administered around the new dark onset facilitated NAT rhythm reentrainment after the 8-h advance of the light-dark cycle.

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Section: Discussionmentioning

confidence: 99%

Melatonin accelerates reentrainment of the circadian rhythm of its own production after an 8-h advance of the light-dark cycle

1989

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“…A s i m i l a r role may prevail in rats, as shown by Quay (1972b). The pineal gland of hamsters, as revealed by Reiter et al (1975), and of ferrets, as shown by Herbert (1971), plays a role in seasonal rhythms of reproduction.…”

Section: Generalizations and Summarymentioning

confidence: 92%

The pineal gland and geographical distribution of animals

Ralph

1975

Int J Biometeorol

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ABSTRACT.-A detailed analysis of the occurrence of parietal eye component of the pineal complex in families of lizards has revealed that those in which the parietal eye is absent in most genera (e. g. Gekkonidae, Teiidae) tend to be restricted to low latitudes, whereas families in which the parietal eye is present in most of the genera (e. g. Agamidae, Iguanidae) extend to higher latitudes. Those few genera which lack parietal eyes in the families where the very great majority have parietal eyes are confined to ranges rather close to the equator. The parietal eye may be important in thermoregulatory or reproductive adaptations at higher latitudes where seasons are more severely varied than at lower latitudes. A pineal body is reported to be absent in crocodilians, edentates and, perhaps, dugongs. All these animals tend to inhabit tropical regions. In contrast, seals and walruses have remarkably large pineal glands and are found at very high latitudes. These few fragments of information cannot be used to support any conclusions, but they do suggest that it might be productive to consider the pineal complexes of animals in the context of their geographical distribution.

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“…In birds and reptiles, the pineal-melatonin system is an essential part of the circadian clockwork (Gaston & Menaker 1968, Tosini & Menaker 1998. In contrast, no overt circadian disruption is observed in pinealectomized mammals (Quay 1970(Quay , 1972, but melatonin may play an important regulatory role in distributing the time signal of the SCN (see below).…”

Section: Scn-pineal Interactionmentioning

confidence: 99%

Interactions between endocrine and circadian systems

Tsang¹,

Barclay

Oster

2013

Journal of Molecular Endocrinology

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In most species, endogenous circadian clocks regulate 24-h rhythms of behavior and physiology. Clock disruption has been associated with decreased cognitive performance and increased propensity to develop obesity, diabetes, and cancer. Many hormonal factors show robust diurnal secretion rhythms, some of which are involved in mediating clock output from the brain to peripheral tissues. In this review, we describe the mechanisms of clock-hormone interaction in mammals, the contribution of different tissue oscillators to hormonal regulation, and how changes in circadian timing impinge on endocrine signalling and downstream processes. We further summarize recent findings suggesting that hormonal signals may feed back on circadian regulation and how this crosstalk interferes with physiological and metabolic homeostasis.

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Pineal Homeostatic Regulation of Shifts in the Circadian Activity Rhythm During Maturation and Aging†

Cited by 48 publications

References 26 publications

Melatonin accelerates reentrainment of the circadian rhythm of its own production after an 8-h advance of the light-dark cycle

Melatonin accelerates reentrainment of the circadian rhythm of its own production after an 8-h advance of the light-dark cycle

The pineal gland and geographical distribution of animals

Interactions between endocrine and circadian systems

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