The Role of Somatostatin and a Long-Acting Analogue, SMS 201-995, in Acute Bleeding due to Peptic Ulceration

Christiansen, John; Yotis, A

doi:10.3109/00365528609087438

Cited by 30 publications

(8 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Of these agents, somatostatin and its analog, octreotide, have a potential role in the treatment of upper gastrointestinal bleeding from peptic ulcer disease, including stress ulceration and gastritis. [7][8][9][10][11] The agents suppress gastric acid secretion by a direct action on parietal and chief cells, and by inhibiting gastrin release. These agents may have also a protective effect on the gastric mucosa by stimulating gastric mucus production and by their vasoconstrictive action on splanchnic arteries, which reduces hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

Extensive hemorrhagic erosive gastritis associated with acute pancreatitis successfully treated with a somatostatin analog

Yabuki

Maekawa

Satoh

et al. 2002

Journal of Gastroenterology

View full text Add to dashboard Cite

In massive hemorrhage from acute gastric mucosal lesions, it is occasionally difficult to control the bleeding with nonsurgical therapy. We used the somatostatin analog, octreotide, which suppresses gastric and pancreatic function, to treat severe hemorrhagic erosive gastritis in a patient with acute pancreatitis. A 22-year-old man presented with epigastralgia and melena. Blood levels of pancreatitis markers were elevated. Computed tomography revealed diffuse enlargement of the pancreas, without fluid collection around the organ. An endoscopic examination showed extensive hemorrhagic erosions over almost the whole gastric mucosa. We diagnosed extensive hemorrhagic erosive gastritis with acute pancreatitis. A protease inhibitor (nafamostat mesilate 50 mg/day) and an H(2) receptor antagonist (famotidine 40 mg/day) were administered by injection for 6 days; the patient's serum and urine amylase levels fell, but the gastric erosions with hemorrhage were not attenuated. Octreotide was given subcutaneously, at a daily dose of 100 microg for 5 days, without famotidine administration. His melena disappeared, and the gastric erosions were markedly decreased. Administration of the somatostatin analog, octreotide, proved to be effective treatment in a patient with severe hemorrhagic erosive gastritis associated with acute pancreatitis.

show abstract

Section: Discussionmentioning

confidence: 99%

Extensive hemorrhagic erosive gastritis associated with acute pancreatitis successfully treated with a somatostatin analog

Yabuki

Maekawa

Satoh

et al. 2002

Journal of Gastroenterology

View full text Add to dashboard Cite

show abstract

“…'~.-~' Several other indications for possible treatment with octreotide such as gastrointestinal haemorrhage, pancreatitis, short bowel syndrome, gastroenteropancreatic tumours and diarrhoea syndromes have been or are currently evaluated in clinical studies. [22][23][24][25][26][27][28] Few data are available on the influence of octreotide on human exocrine pancreatic ~ecretion.~'-j~ A reduction of pancreatic fluid output up to 75%" and of enzyme secretion up to 80%~' was reported.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of human exocrine pancreatic secretion by the long‐acting somatostatin analogue octreotide (SMS 201‐995)

Kemmer

Malfertheiner

Büchler

et al. 1992

Aliment Pharmacol Ther

View full text Add to dashboard Cite

The new long-acting somatostatin analogue octreotide was investigated for its influence on segretatagogue-stimulated human exocrine pancreatic secretion. Eighteen healthy volunteers participated in the study. During duodenal intubation with a background stimulation of either secretin 1 U. kg/h or secretin 1 U. kg/h + ceruletide, 120 ng. kg/h, octreotide was infused at doses of 5, 20 and 80 pg/h in a placebo-controlled randomized double-blind crossover trial. Duodenal juice samples were collected in 10-min intervals, and amylase, trypsin, chymotrypsin, and bicarbonate were measured in the individual fractions. 59%, trypsin between 28 and 72%, chymotrypsin between 55 and 70%, and bicarbonate between 0 and 31 % with 5, 20 and 80 pg/h octreotide.During secretin and ceruletide stimulation, amylase was significantly inhibited by 84%, 789'0, 819'0, trypsin by 76%, 55 %, 52%, chymotrypsin by 77%, 55 %, 60%, and bicarbonate by 25 %, XI%, 19% with 5,2O, and 80pg/h octreotide, respectively (all decreases P < 0.05).During secretin stimulation, amylase was inhibited between 4 1 and Correspondence to : Professor Dr med. P. Malfertheiner, Universitat Ulm, Abteilung Innere Medizin 11,

show abstract

“…As a matter of fact, both somatostatin [77,78] and octreotide [79] increase LESP in humans. These peptides also significantly inhibit acid secretion [80,81] either directly and through inhibition of gastrin release [82]. Pepsinogen secretion is inhibited by somatostatin as well [83].…”

Section: Somatostatin For Upper Gi Bleedingmentioning

confidence: 99%

“…As for bleeding varices, the inhibition of acid and pepsin secretion [80][81][82][83] by these peptides represents the key pharmacological action for reducing the risk of rebleeding by preventing the dissolution of fibrin clot. The increased mucus secretion [92], together with the peptide ability to stimulate prostaglandin production by gastric epithelial cells [93] may account for its remarkable mucosal protective activity [94].…”

Section: Somatostatin For Upper Gi Bleedingmentioning

confidence: 99%

Somatostatin for Upper Gastrointestinal Hemorrhage and Pancreatic Surgery

Scarpignato

Pelosini

1999

Digestion

View full text Add to dashboard Cite

The Role of Somatostatin and a Long-Acting Analogue, SMS 201-995, in Acute Bleeding due to Peptic Ulceration

Cited by 30 publications

References 24 publications

Extensive hemorrhagic erosive gastritis associated with acute pancreatitis successfully treated with a somatostatin analog

Extensive hemorrhagic erosive gastritis associated with acute pancreatitis successfully treated with a somatostatin analog

Inhibition of human exocrine pancreatic secretion by the long‐acting somatostatin analogue octreotide (SMS 201‐995)

Somatostatin for Upper Gastrointestinal Hemorrhage and Pancreatic Surgery

Contact Info

Product

Resources

About