Extensive hemorrhagic erosive gastritis associated with acute pancreatitis successfully treated with a somatostatin analog

Yabuki, Kiyotaka; Maekawa, Takeo; Satoh, Koichi; Tamasaki, Yoshihisa; Maekawa, Hiroshi; Kudoh, Keizo; Aoki, Eizaburo

doi:10.1007/s005350200120

Cited by 2 publications

(2 citation statements)

References 17 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Results of these findings in islet cells of human pancreas were consistent with previously reported studies [8,10]. Octreotide generally delivers a good clinical outcome for patients with pancreatitis or prevents pancreatitis after intervention to pancreatic duct in those patients [41][42][43][44], but its mechanism was not well characterized. The results of our present study suspected that octreotide action through sstr4 and sstr5 may play important roles in the regulation of pancreatic juice secretion in acinar cells of pancreas.…”

Section: Discussionsupporting

confidence: 89%

Systemic Distribution of Somatostatin Receptor Subtypes in Human: An Immunohistochemical Study

et al. 2005

View full text Add to dashboard Cite

Abstract. Somatostatin is well known to inhibit the hormone secretion of various peptides. This action has been considered to be generally mediated via six different specific somatostatin receptors (sstr), sstr1, sstr2A, sstr2B, sstr3, sstr4, and sstr5. It then becomes very important to demonstrate the localization of these sstr subtypes in order to elucidate the possible biological and/or clinical significance of somatostatin actions. These sstr subtypes have been demonstrated to be expressed throughout the human body, including the central nervous system, gastrointestinal tract, pancreas, kidney, and other organs, but its details, especially its systemic distribution and localization in tissue compartments, have yet to be examined thoroughly in human. Therefore, in this study, we examined the systemic localization of all six somatostatin receptors in normal human organs using immunohistochemistry with recently developed specific antibodies against these receptor subtypes. In all of the human tissues examined, various sstr subtypes were detected not only in parenchymal cells but also in various stromal cells such as lymphocytes, fibroblasts, and endothelial cells. Among human tissues in which the presence of sstr has not been previously reported, the parotid gland demonstrated immunoreactivity for sstr2B and sstr5, bronchial gland for sstr1, 2B, 3, 4, 5, parathyroid gland for sstr1, 3, 4, and duodenum for all subtypes immunoreactivity. The great majority of other organs examined demonstrated results consistent with those of previously reported biochemical studies. In pancreatic islet cells, only sstr2A was positive in all the cases but other sstr subtypes were associated with marked intraislet heterogeneity in their distribution. In stomach, all subtypes of receptor were detected in various cell types of the mucosa, but none in ECL cells of fundic gland. These findings demonstrated the broad systemic actions of somatostatin in non-endocrine cells.

show abstract

Section: Discussionsupporting

confidence: 89%

Systemic Distribution of Somatostatin Receptor Subtypes in Human: An Immunohistochemical Study

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Diverticulitis may present with abdominal pain, low-grade fever, a change in bowel habits, and dysuria (Stollman & Raskin, 1999). Erosive hemorrhagic gastritis also will cause melena (Yabuki et al, 2002) and, if associated with infection and significant blood loss, may be accompanied by fever and fatigue. Erosive hemorrhagic gastritis also will cause melena (Yabuki et al, 2002) and, if associated with infection and significant blood loss, may be accompanied by fever and fatigue.…”

Section: Acute Abdominal Symptomsmentioning

confidence: 99%

Diagnosing Gastric Carcinoma

Stovall

2008

Clinical Journal of Oncology Nursing

View full text Add to dashboard Cite

The clinical presentation of abdominal pain, fatigue, and fever represents a number of potential diagnoses. Differential diagnoses for these common signs and symptoms include appendicitis, cholecystitis, diverticulitis, gastritis, renal colic, and myocardial infarction. Presenting symptoms are more likely to represent a gastrointestinal etiology with the addition of melena, ranging from a simple gastritis to a gastrointestinal malignancy. This column will explore the diagnostic process for evaluating symptoms of abdominal pain, fatigue, fever, and melena in a 58-year-old man from the perspective of an oncology nurse practitioner. An algorithm for narrowing from a broad list of potential diagnoses at the patient's initial presentation to the most probable diagnoses is described, and the clinical reasoning process for narrowing the list is discussed. Patient DescriptionMr. I is a 58-year-old Japanese man who presents to clinic with complaints of abdominal pain, fatigue, and fever for the past three to four days. He also states that he has had black stools for the past 24 hours. His wife and two adult children accompany him to the clinic.

show abstract

Extensive hemorrhagic erosive gastritis associated with acute pancreatitis successfully treated with a somatostatin analog

Cited by 2 publications

References 17 publications

Systemic Distribution of Somatostatin Receptor Subtypes in Human: An Immunohistochemical Study

Systemic Distribution of Somatostatin Receptor Subtypes in Human: An Immunohistochemical Study

Diagnosing Gastric Carcinoma

Contact Info

Product

Resources

About