Somatostatin for Upper Gastrointestinal Hemorrhage and Pancreatic Surgery

Scarpignato, Carmelo; Pelosini, Iva

doi:10.1159/000051484

Cited by 40 publications

(15 citation statements)

References 96 publications

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“…The effectiveness of somatostatin may be due to its ability to decrease the hepatic venous pressure gradient, to decrease the intestinal absorption of fats, to decrease the triglyceride concentration in the thoracic duct and to attenuate splanchnic blood flow (15-17). In addition, it could be that the lymphatic vessels contain somatostatin receptors, like the blood vessels in the splanchnic area, and that their constriction reduces the lymph production (18, 19). …”

Section: Discussionmentioning

confidence: 99%

Somatostatin for Postoperative Chylothorax after Surgery for Children with Congenital Heart Disease

et al. 2005

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Chylothorax is a rare but serious postoperative condition with a high rate of morbidity that may lead to death of children with congenital heart disease. Here we reviewed nine consecutive cases with chylothorax in infants and children following cardiac surgery from March 2002 to February 2003. Somatostatin was added to conservative treatment proctocol to increase effectiveness of therapy in all cases. The duration of somatostatin therapy varied from 7 to 32 days. All cases of chylothorax were successfully treated with intravenous infusion of somatostatin as an adjunctive treatment. Even though two cases showed rebound phenomena, we avoided any surgical procedure in the nine patients who treated with conservative management combined with somatostatin. No significant side effects of somatostatin were observed. It seems that somatostatin is effective, noninvasive and safe therapeutic modality. It can be used as an adjunctive treatment to conservative management to control postoperative chylothorax in children with congenital heart disease.

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Section: Discussionmentioning

confidence: 99%

Somatostatin for Postoperative Chylothorax after Surgery for Children with Congenital Heart Disease

et al. 2005

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“…We also examined the susceptibility to KLK7 hydrolysis of somatostatins SS-14 and SS-28, and substance P because these polypeptides contain in their sequences a pair of F-F amino acids that are possible cleavage sites of KLK7. In addition, KLK7 has significant overlap distribution in human tissues [14] with that of somatostatin found in the central nervous system, peripheral nerves, gastrointestinal and urogenital tracts [26] and also in skin [27][28][29]. Substance P is a neuropeptide with roles in pain and inflammation, directly induces keratinocyte nerve growth factor, and whose extracellular concentrations are regulated by proteolysis [30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Specificity studies on Kallikrein-related peptidase 7 (KLK7) and effects of osmolytes and glycosaminoglycans on its peptidase activity

Oliveira

Bertolin

Andrade

et al. 2015

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

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“…The main mechanisms by which somatostatin analogues are thought to act in reducing bleeding include: platelet aggregation [39], decreased duodenal and splanchnic blood flow [40], increased vascular resistance [41], down-regulation of vascular endothelial growth factor (VEGF) expression [42] and inhibition of angiogenesis [42,43]. Somatostatin analogues have a better side-effect profile than other drugs such as anti-angiogenic drug [44,45] and hormonal treatment [46].…”

Section: Discussionmentioning

confidence: 99%

Refractory Anaemia Secondary to Small Bowel Angioectasias - Comparison between Endotherapy Alone versus Combination with Somatostatin Analogues

Zammit

Sidhu

Sanders

2017

JGLD

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Background & Aims: Patients with small bowel angioectasias (SBAs) can be difficult to manage as they are generally elderly with multiple co-morbidities. Angioectasias are multiple and tend to recur. Argon plasma coagulation (APC), despite being a commonly used method to treat these patients has an associated persistent rate of re-bleeding necessitating additional treatment to manage these patients.Methods: All patients with refractory iron deficiency anaemia secondary to SBAs were retrospectively subdivided into two groups. Patients in group 1 were managed with double balloon enteroscopy (DBE) and APC alone and those in group 2 received Lanreotide in addition to DBE and APC.Results: A total of 49 patients were included in this study: group 1: 37 patients (75.5%), group 2: 12 patients (24.5%). All had significant comorbidities and the mean duration of anaemia was 114.3, SD 307.0 months. Significant improvements in haemoglobin (Hb) (11g/L vs 3.2g/L p=0.043), transfusion requirements per month (0.8 vs 4.7 p=0.052) and mean bleeding episodes (1.08 vs 2.6 p=0.032) were demonstrated in group 2 when compared to group 1. One patient developed symptomatic gallstone disease and one patient stopped Lanreotide due to a lack of response.Conclusions: This is the first study comparing endotherapy to a combination of endotherapy and pharmacotherapy. It shows a significantly better outcome in patients receiving a combination of endotherapy and Lanreotide. Lanreotide can be a safe additional treatment in patients not responding to APC alone.Abbreviations: APC: argon plasma coagulation; CE: capsule endoscopy; DBE double balloon enteroscopy; Hb: hemoglobin; OGIB: over gastrointestinal bleeding; SBAs: small bowel angioectasias.

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Somatostatin for Upper Gastrointestinal Hemorrhage and Pancreatic Surgery

Cited by 40 publications

References 96 publications

Somatostatin for Postoperative Chylothorax after Surgery for Children with Congenital Heart Disease

Somatostatin for Postoperative Chylothorax after Surgery for Children with Congenital Heart Disease

Specificity studies on Kallikrein-related peptidase 7 (KLK7) and effects of osmolytes and glycosaminoglycans on its peptidase activity

Refractory Anaemia Secondary to Small Bowel Angioectasias - Comparison between Endotherapy Alone versus Combination with Somatostatin Analogues

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