The role of oxidative stress in alterations of hematological parameters and inflammatory markers induced by early hypercholesterolemia

Karbiner, María Sofía; Sierra, Liliana; Minahk, Carlos; Fonio, María C.; Bruno, María Peral de; Jerez, Susana

doi:10.1016/j.lfs.2013.08.003

Cited by 34 publications

(23 citation statements)

References 32 publications

(37 reference statements)

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“…Karamouzis et al [22] have shown that manifestations of partial and full MetS in obese children and adolescent girls are associated with enhanced oxidative stress and activated platelet function. In a high-fat diet animal model, elevated oxidative markers such as thiobarbituric acid substances and glutathione are related with higher platelet counts, CRP, and leukocyte counts [23]. In addition, Bonaccio et al [24] demonstrated that the Mediterranean diets with higher antioxidants decreased both leukocyte and platelet counts, which may be explained by oxidative stress reduction.…”

Section: Discussionmentioning

confidence: 99%

The association between platelet count and metabolic syndrome in children and adolescents

et al. 2014

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Section: Discussionmentioning

confidence: 99%

The association between platelet count and metabolic syndrome in children and adolescents

et al. 2014

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“…By increasing monocyte attachment to the ECs, OS is also able to induce foam cell generation. Thereafter, the large amount of cholesterol stored within foam cells sustains ROS production (Karbiner et al, ). Clinical studies confirmed experimental evidence by reporting a close relationship between hypercholesterolemia, OS, and inflammation (Karbiner et al, ; Narverud et al, ; Real et al, ).…”

Section: Os In the Initiation Of Atherosclerosis In Hypercholesterolemiamentioning

confidence: 99%

“…Thereafter, the large amount of cholesterol stored within foam cells sustains ROS production (Karbiner et al, ). Clinical studies confirmed experimental evidence by reporting a close relationship between hypercholesterolemia, OS, and inflammation (Karbiner et al, ; Narverud et al, ; Real et al, ). In particular, C‐reactive protein (CRP) was found to be higher in FH children as compared to familial combined hyperlipidaemic children and normal children (Guardamagna et al, ).…”

Section: Os In the Initiation Of Atherosclerosis In Hypercholesterolemiamentioning

confidence: 99%

Oxidative burden in familial hypercholesterolemia

Mollazadeh¹,

Carbone

Montecucco

et al. 2018

Journal Cellular Physiology

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Familial hypercholesterolemia (FH) is a genetic disorder characterized by high serum levels of low-density lipoprotein cholesterol (LDL-c). FH is characterized by accelerated development of atherosclerosis and represents the most frequent hereditary cause of premature coronary heart disease. Mutations of the LDL receptor gene are the genetic signature of FH, resulting in abnormal levels of circulating LDLs. Moreover, FH promotes the generation of reactive oxygen species (ROS) which is another key mechanism involved in atherosclerosis development and progression. The aim of this narrative review is to update the current knowledge on the pathophysiological mechanisms linking FH to ROS generation and their detrimental impact on atherosclerotic pathophysiology. With this purpose, we reviewed experimental and clinical data on the association between FH and OS and the functional role of OS as a promoter of inflammation and atherosclerosis. In this regard, oxidant species such as oxidized LDL, malondialdehyde, ROS, and isoprostanes emerged as leading mediators of the oxidative injury in FH. In conclusion, targeting oxidative stress may be a promising therapeutic strategy to reduce atherogenesis in patients with FH.

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“…Then, it was centrifuged and allowed to stand for 1 hr at 37°C. The supernatant was taken, and the absorbance was noted at 540 nm in a UV-visible spectrophotometer [14]. Osmotic fragility curve was then constructed by plotting concentration of sodium chloride in X axis and for both loaded and normal erythrocyte.…”

Section: Osmotic Fragility Testmentioning

confidence: 99%

Design and Invitro Characterization of Metformin Loaded Resealed Erythrocytes

Viswanad¹,

Aiswarya²,

Parvathy³

et al. 2017

Asian J Pharm Clin Res

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Objective: Metformin is an oral antidiabetic drug in the biguanide class. It is the first-line drug of choice for the treatment of type 2 diabetes. The objective of this study was to retard the release of metformin using carrier erythrocyte for getting a parenteral slow release depot formulation. Methods:The study retards the release of metformin by encapsulating in carrier erythrocyte. Endocytosis is the method used for the encapsulation of the drug metformin.Results: The optimized formulation shows 98.34% of drug release within 12 days. From the in vitro release data, zero order kinetic graph shows the best fit graph. % cell recovered was found to be 73-78% and it suggests that the loading technique was less destructive. Conclusion:The optimized formulation is a perfect carrier for the parenteral slow release depot of metformin.

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The role of oxidative stress in alterations of hematological parameters and inflammatory markers induced by early hypercholesterolemia

Cited by 34 publications

References 32 publications

The association between platelet count and metabolic syndrome in children and adolescents

The association between platelet count and metabolic syndrome in children and adolescents

Oxidative burden in familial hypercholesterolemia

Design and Invitro Characterization of Metformin Loaded Resealed Erythrocytes

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