The association between platelet count and metabolic syndrome in children and adolescents

Lim, Hyoung Ji; Seo, Min Seok; Shim, Jae Yong; Kim, Kyu Earn; Shin, Youn Ho; Lee, Yong-Jae

doi:10.3109/09537104.2014.995613

Cited by 23 publications

(30 citation statements)

References 25 publications

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“…19,20 Other platelet indices studied include platelet-tolymphocyte ratio, which was found to be elevated in MetS patients, as well as shown be a marker for cardiovascular dysfunction in MetS patients by Akboga et al 21,22 A large multicenter study based in South Korea, spanning 2 years from 2010 to 2012 and involving 2,228 patients by Lim et al, showed that elevated platelet indices were a risk stratification marker for development of MetS not only in adults but in the pediatric and adolescent population as well. 23 Similar results on proinflammatory biomarkers in MetS patients in the adolescent age group were documented by Can et al 24 On comparison with controls, Zaccardi et al found that MPV was significantly higher in patients with type 2 DM but not in MetS patients, findings similar to what were obtained in our study as well. 25,26…”

Section: Discussionsupporting

confidence: 92%

Study of Platelet Indices in Patients with Metabolic Syndrome

Reddy

Khandekar

Acharya

et al. 2019

IJRSMS

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Introduction Metabolic syndrome (MetS) is a combination of abdominal obesity, atherogenic dyslipidemia, elevated blood pressure, and elevated plasma glucose. MetS patients have higher chances of developing insulin resistance, visceral adiposity, atherogenic dyslipidemia, and thus coronary artery disease and stroke. Alteration of platelet indices in diabetes mellitus, atherosclerosis, and other proinflammatory states has been described in multiple studies. Thus, this study was carried out to assess platelet indices in MetS. Objectives This study was carried out to assess platelet indices in MetS. Methods A cross-sectional study was carried out at Acharya Vinoba Bhave Rural Hospital, a tertiary care center over a period of 2 months from June 1, 2018 to July 31, 2018. Fifty patients diagnosed as having MetS, and 50 healthy controls were chosen. Estimation of anthropometric parameters including waist circumference; measurement of blood pressure; biochemical parameters including lipid profile; and platelet indices including plateletcrit, mean platelet volume (MPV), and platelet distribution width (PDW) were carried out. Statistical Analysis Statistical analyses were carried out using inferential statistics, including chi-square test and Student's unpaired t-test, and software SPSS version 22.0 (IBM Corporation, Armonk, New York, United States) with GraphPad Prism version 6.0 (Informer Technologies, Inc. Los Angeles, California, United States) was used, with p < 0.05 being considered as significant. Results A statistically significant, positive correlation was found between the waist circumference, systolic blood pressure, serum triglyceride levels, and plateletcrit, with the MetS status of patients (p < 0.05). Conclusion This study revealed that MetS is a proinflammatory and prothrombotic state, characterized by alteration of platelet indices. Plateletcrit was shown to be a statistically significant biomarker along with other parameters such as waist circumference, systolic blood pressure, and serum triglyceride levels. Early detection and follow-up of patients using these markers can lead to an overall decline in morbidity and mortality owing to MetS.

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Section: Discussionsupporting

confidence: 92%

Study of Platelet Indices in Patients with Metabolic Syndrome

Reddy

Khandekar

Acharya

et al. 2019

IJRSMS

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“…3 Several studies have found that hematological parameters, including white blood cell (WBC), red blood cell (RBC) and platelet counts, platelet to lymphocyte ratio, neutrophil to lymphocyte ratio (NLR), lymphocyte-tomonocyte ratio (LMR), monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) and lymphocyte to high-density lipoprotein ratio (LHR), may be related to MetS and the atherosclerotic process, as potential indicators of prothrombotic and proinflammatory states. [4][5][6][7][8] As known, HDL-C plays an important role in antiinflammatory, antioxidant and antithrombotic progress, and can inhibit cytokine-induced expression of endothelial cell adhesion molecules. 9,10 It was reported that the MHR was independently associated with coronary atherosclerosis in patients with stable coronary artery disease; 11 however, there is inconsistency in changes in the lymphocyte count in MetS patients.…”

Section: Introductionmentioning

confidence: 99%

<p>Comparison of the Value of Neutrophil to High-Density Lipoprotein Cholesterol Ratio and Lymphocyte to High-Density Lipoprotein Cholesterol Ratio for Predicting Metabolic Syndrome Among a Population in the Southern Coast of China</p>

Chen¹,

Chen²,

Tang³

et al. 2020

DMSO

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Background: This study aimed to determine the optimal cutoff values and evaluate the associations of neutrophil to high-density lipoprotein cholesterol ratio (NHR) and lymphocyte to high-density lipoprotein cholesterol ratio (LHR) with metabolic syndrome (MetS), stratified by sex. Methods: A large-scale cross-sectional survey was conducted among 1401 adults from January to April 2018 in six communities in Wanzhai Town, Zhuhai City, on the southern coast of China. Receiver operating characteristics (ROC) analyses and logistic regression analysis were conducted to assess the optimal cutoff and value of NHR and LHR for predicting MetS. Results: Hematological parameters showed the correlation with the occurrence of MetS (red blood cells, hemoglobin, and white blood cells and subtypes). Binomial logistic regression analysis found that LHR (OR: 3.671; 95% CI: 2.385-5.651; p<0.001) and NHR (OR: 1.728; 95% CI: 1.353-2.207; p<0.001) can predict MetS in females, independent of confounding factors. Although LHR (OR: 1.571; 95% CI: 1.001-2.468; p=0.05) and NHR (OR: 1.163; 95% CI: 0.909-1.48; p<0.01) were independent risk factors for MetS in males after adjustment for age, current smoking, current alcohol use, physical activity, educational attainment, waist circumference, systolic pressure, diastolic pressure and hypersensitive C-reactive protein (hs-CRP), when further adjusted for fasting plasma glucose level, LHR and NHR, both lost their independence. ROC curves showed that LHR had the highest AUC for predicting MetS in females and NHR had the highest AUC in males. The cutoff points of LHR and NHR were 1.36 and 2.31 in females, and 1.96 and 3.38 in males. Conclusion: LHR and NHR may become valuable makers and have strong predictive power for predicting MetS, especially in females.

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“…[ 15 , 16 ] However, in another study, higher PLT count was associated with increased prevalence and risk of MS in both genders. [ 17 ]…”

Section: Introductionmentioning

confidence: 99%

The associations between leukocyte, erythrocyte or platelet, and metabolic syndrome in different genders of Chinese

Zhou

Meng²,

Liu³

et al. 2016

Medicine

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Leukocyte, erythrocyte or platelet and metabolic syndrome (MS) are closely correlated, and there exist gender differences. We aimed to explore the associations between the hematological parameters and MS in different genders of Chinese. This cross-sectional study included 32,900 participants (20,733 males, 12,167 females) who were enrolled in a health examination. Clinical data including anthropometric measurements and serum parameters were collected. The associations between hematological parameters and MS of both genders were analyzed separately. Odds ratio (OR) of MS was calculated by binary logistic regression models. All hematological parameters were related to MS. With leukocyte and erythrocyte counts rising, the risks of developing MS increased in both genders, which was more obvious in women. For instance, in model 3, the ORs of MS in leukocyte quartiles in females were from 1.333 to 2.045 (P < 0.01), while in males, from 1.238 to 1.675 (P < 0.01). Platelet seemed as a protective factor in males. Model 1 and model 3 in quartile 2 demonstrated ORs of 0.922 (P < 0.05) and 0.912 (P < 0.05). However, platelet acted as risk factor in female. For instance, the ORs were 1.253 (P < 0.01), 1.461 (P < 0.01), and 1.322 (P < 0.01) in platelet quartile 4 of all 3 models in female. Gender has influences on the associations between leukocyte, erythrocyte or platelet, and MS. In both genders, higher levels of leukocyte and erythrocyte increased risks of MS. For men, platelet was a protective factor, but for women, platelet seemed as a risk factor.

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The association between platelet count and metabolic syndrome in children and adolescents

Abstract: Higher platelet count was associated with increased prevalence and risk of MetS in children and adolescents.

Cited by 23 publications

References 25 publications

Study of Platelet Indices in Patients with Metabolic Syndrome

Study of Platelet Indices in Patients with Metabolic Syndrome

<p>Comparison of the Value of Neutrophil to High-Density Lipoprotein Cholesterol Ratio and Lymphocyte to High-Density Lipoprotein Cholesterol Ratio for Predicting Metabolic Syndrome Among a Population in the Southern Coast of China</p>

The associations between leukocyte, erythrocyte or platelet, and metabolic syndrome in different genders of Chinese

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