The Role of Mechanical Forces in the Initiation and Progression of Osteoarthritis

Buckwalter, Joseph A.

doi:10.1007/s11420-011-9251-y

Cited by 23 publications

(16 citation statements)

References 19 publications

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“…Chronically altered joint mechanics, including malalignment, instability, and incongruity are widely accepted as contributory factors in the development of ankle PTOA . The relative importance of these chronic abnormal loading conditions versus acute mechanical trauma to the articular surface at the time of injury remains unclear, and likely varies between ankle injury types .…”

Section: Etiology Of Talocrural Oa—the Association Between Cartilage mentioning

confidence: 99%

“…PTOA models involving joint instability or the generation of an osteochondral fragment are valuable tools, however these models do not reflect the contributions of acute trauma to the articular cartilage at the time of injury. Although the specific injury parameters required to initiate clinical PTOA remain unclear, these mechanical thresholds have been studied in many model systems, and experimental evidence supports the importance of loading magnitude and rate as predictors of cartilage degeneration …”

Section: Considerations For Development Of New Preclinical Models Of mentioning

confidence: 99%

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Post‐traumatic osteoarthritis of the ankle: A distinct clinical entity requiring new research approaches

Delco

Kennedy

Bonassar

et al. 2016

Journal Orthopaedic Research

103

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The diagnosis of ankle osteoarthritis (OA) is increasing as a result of advancements in non-invasive imaging modalities such as magnetic resonance imaging, improved arthroscopic surgical technology and heightened awareness among clinicians. Unlike OA of the knee, primary or age-related ankle OA is rare, with the majority of ankle OA classified as post-traumatic (PTOA). Ankle trauma, more specifically ankle sprain, is the single most common athletic injury, and no effective therapies are available to prevent or slow progression of PTOA. Despite the high incidence of ankle trauma and OA, ankle-related OA research is sparse, with the majority of clinical and basic studies pertaining to the knee joint. Fundamental differences exist between joints including their structure and molecular composition, response to trauma, susceptibility to OA, clinical manifestations of disease, and response to treatment. Considerable evidence suggests that research findings from knee should not be extrapolated to the ankle, however few ankle-specific preclinical models of PTOA are currently available. The objective of this article is to review the current state of ankle OA investigation, highlighting important differences between the ankle and knee that may limit the extent to which research findings from knee models are applicable to the ankle joint. Considerations for the development of new ankle-specific, clinically relevant animal models are discussed.

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Section: Etiology Of Talocrural Oa—the Association Between Cartilage mentioning

confidence: 99%

Section: Considerations For Development Of New Preclinical Models Of mentioning

confidence: 99%

Post‐traumatic osteoarthritis of the ankle: A distinct clinical entity requiring new research approaches

Delco

Kennedy

Bonassar

et al. 2016

Journal Orthopaedic Research

103

View full text Add to dashboard Cite

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“…Pain is generally dull aching and common during the initial phases and is due to the synovitis. 13 Some patients have morning joint stiffness and increased sensitivity to cold and damp. The pain relieving factors include rest and NSAIDs.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…It is divided into three slow progressive phases. 13,14 The disease process takes about 5.5 years from initiation to the final burnout phase. 14 1.…”

mentioning

confidence: 99%

Prevalence and diagnostic features of osteoarthrosis of the temporomandibular joint: a review

Bansal

2016

Int J Res Orthop

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Temporomandibular disorders (TMD) consist of not only the internal derangement of Temporomandibular joint (TMJ) but also areas extrinsic to TMJ. Osteoarthritis is a common degenerative joint disease that manifests as a chronic debilitating disease and occurs due to degradation and loss of articular cartilage. There occur changes in the subchondral bone and other soft tissues. Osteoarthritis is not uncommon in the Temporomandibular joints (TMJs). The etiopathogenesis of osteoarthritis is associated with multiple risk factors. The disease progresses slowly and passes through different phases with periods of remission and ultimately results in the burnout phase. It needs a good understanding of the diagnostic algorithm and that facilitates better management of the disease in the TMJ. The aim of this review article is to highlight and update the prevalence, diagnosis, pathogenesis and general characteristics of TMJ Osteoarthritis.

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“…Trauma includes past fractures, jaw trauma, repetitive high-impact and torsional loads. Ligament laxity, internal derangements and inadequate muscle strength are examples of joint and muscle disorders [8][9][10]. The natural course of the disease consists of periods of remission.…”

Section: Introductionmentioning

confidence: 99%

Addressing the Gaps: Therapeutic and Prognostic Considerations in Temporomandibular Joint Osteoarthrosis

Bansal¹

2017

JOENTR

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The Role of Mechanical Forces in the Initiation and Progression of Osteoarthritis

Cited by 23 publications

References 19 publications

Post‐traumatic osteoarthritis of the ankle: A distinct clinical entity requiring new research approaches

Post‐traumatic osteoarthritis of the ankle: A distinct clinical entity requiring new research approaches

Prevalence and diagnostic features of osteoarthrosis of the temporomandibular joint: a review

Addressing the Gaps: Therapeutic and Prognostic Considerations in Temporomandibular Joint Osteoarthrosis

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