The relationship of vitamin D with non-traditional risk factors for cardiovascular disease in subjects with metabolic syndrome

Makariou, Stefania; Liberopoulos, Evangelos N.; Florentin, Matilda; Lagos, Konstantinos; Gazi, Irene F.; Challa, Anna; Elisaf, Moses

doi:10.5114/aoms.2012.29398

Cited by 26 publications

(20 citation statements)

References 37 publications

(40 reference statements)

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“…These results are consistent with recent work on patients with venous thromboembolism in which no association between 25(OH)D and hs-CRP was reported [38]. Similarly, data from a study conducted by Makariou et al [39] showed no significant relations between plasma 25(OH)D level and hs-CRP in patients with metabolic syndrome. These insignificant associations in our study are in disagreement with the findings of some other studies [40,41].…”

Section: Discussionsupporting

confidence: 82%

Vitamin D Status Is Related to Oxidative Stress But Not High-Sensitive C-Reactive Protein in Women with Pre-Eclampsia

Gargari

Tabrizi²,

Sadien³

et al. 2015

Gynecol Obstet Invest

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Background/Aims: Pre-eclampsia (PE) is associated with unfavorable metabolic profiles. Oxidative stress and inflammation have been increasingly postulated as major contributors to PE. Research suggests that vitamin D status is disturbed in women with PE. The aims of this study were to compare the serum levels of vitamin D and oxidative stress status in women with PE vs. women with normal pregnancies, and to evaluate the relationship between these 2 factors in women with PE. Methods: In this case-control study, 40 women with PE and 40 healthy pregnant women were selected, and high-sensitivity C-reactive protein, malondialdehyde (MDA), total antioxidant capacity (TAC) and 25-hydroxyvitamin D (25(OH)D) levels were assessed. We compared the biochemical indicators between the 2 groups by analysing the data using the independent t test, Mann-Whitney U test, chi-square and logistic regression. Results: Compared with the controls, the serum levels of MDA in women with PE were significantly higher (p = 0.001) and TAC and 25(OH)D levels were significantly lower (p < 0.05). TAC concentration was positively associated with 25(OH)D levels in cases of PE (β = 0.428, p = 0.01). Conclusion: Our findings show lower levels of TAC and 25(OH)D in women with PE in comparison to controls, while having similar vitamin D intakes. In addition, our results suggest a positive relationship between TAC concentration and 25(OH)D levels in PE cases.

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Section: Discussionsupporting

confidence: 82%

Vitamin D Status Is Related to Oxidative Stress But Not High-Sensitive C-Reactive Protein in Women with Pre-Eclampsia

Gargari

Tabrizi²,

Sadien³

et al. 2015

Gynecol Obstet Invest

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“…34,35 In addition, a recent study has reported a positive association of PTH with hsCRP in obese adolescents after controlling for vitamin D levels, 5 consistent with our data. PTH has also been reported to be an independent predictor of systolic (SBP) and diastolic blood pressure (DBP), but not other components of the metabolic syndrome, in morbidly obese adults.…”

Section: Discussionsupporting

confidence: 91%

The Ratio of Parathyroid Hormone to Vitamin D Is a Determinant of Cardiovascular Risk and Insulin Sensitivity in Adolescent Girls

Stanley

Bredella

Pierce

et al. 2013

Metabolic Syndrome and Related Disorders

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Background: Vitamin D insufficiency and higher testosterone are common in obese girls and may adversely affect glucose homeostasis and cardiovascular risk. Data are conflicting regarding the impact of parathyroid hormone (PTH) on these factors. Our objective was to determine associations of 25-hydroxyvitamin D (25-OHD), PTH, and testosterone with measures of glucose homeostasis and cardiovascular risk in adolescent girls after controlling for regional adiposity, with the hypothesis that lower 25-OHD, a higher PTH or PTH/25-OHD ratio, and higher testosterone would be associated with lower insulin sensitivity and greater cardiovascular risk. Methods: A total of 15 obese girls and 15 matched normal weight controls (12-18 years) underwent fasting measurements of 25-OHD, PTH, testosterone, sex hormone-binding globulin (SHBG), high-sensitivity C-reactive protein (hsCRP), oral glucose tolerance testing, and quantification of visceral (VAT) and subcutaneous (SAT) fat by magnetic resonance imaging (MRI). Results: There were no associations of 25-OHD with measures of glucose homeostasis or hsCRP. In contrast, PTH and PTH/25-OHD were associated negatively with homeostasis model assessment of insulin resistance (HOMA-IR) and positively with quantitative insulin sensitivity check index (QUICKI) in obese girls but not controls. These associations remained significant after controlling for body mass index standard deviation score (BMI-SDS), but not for VAT. On regression modeling, PTH/25-OHD was positively associated with hsCRP after controlling for BMI-SDS or VAT. Free testosterone positively predicted the corrected insulin response. Conclusions: In obese girls, PTH/25-OHD is positively associated with measures of insulin sensitivity and hsCRP. Further studies are needed to investigate the relationship between PTH and glucose homeostasis in obesity.

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“…We failed to find a significant association of baseline 25(OH)D with the other MetS components at follow‐up. Although previous cross‐sectional and prospective studies have reported inverse associations of 25(OH)D with several of the MetS components, results have not been consistent . Further, a number of randomized controlled trials have investigated the effects of vitamin D supplementation on various metabolic syndrome components, although results have been inconsistent, possibly due to inadequate statistical power, dose and/or the fact that these trials were not designed for specific MetS components as outcomes.…”

Section: Discussionmentioning

confidence: 95%

Prospective association of 25(OH)D with metabolic syndrome

Kayaniyil

Harris

Retnakaran

et al. 2013

Clinical Endocrinology

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SummaryContext Vitamin D may play a role in the aetiology of the metabolic syndrome (MetS), yet the majority of previous studies have been cross-sectional, and the limited number of prospective studies has yielded inconsistent results. Objective To examine the prospective association of vitamin D [25-hydroxyvitamin D, 25(OH)D] with MetS in a multi-ethnic cohort of adults in Ontario, Canada. Design Nondiabetic individuals with pre-existing MetS risk factors were recruited for participation in the PROspective Metabolism and ISlet cell Evaluation (PROMISE) cohort study, a longitudinal study of the determinants of insulin resistance and MetS. Methods Of the 654 participants enrolled at baseline, 489 attended a 3-year follow-up visit. There were 301 participants eligible for the analysis of 25(OH)D with incident MetS (age 49Á2 AE 9Á3 years old, 75Á4% female), after excluding 188 (38Á5%) prevalent MetS cases at baseline. Longitudinal change in MetS components was assessed in the entire follow-up cohort. Results There were 76 (15Á5%) participants who developed MetS over the 3-years of follow-up. Multivariate logistic regression analyses indicated a decreased risk of MetS at follow-up per standard deviation increase in baseline 25(OH)D after adjustment for sociodemographics, season, baseline and change in supplement use and physical activity and insulin resistance (OR = 0Á63, 95% CI 0Á44-0Á90). Multivariate linear regression analyses revealed a significant inverse association of baseline 25(OH)D with fasting glucose at follow-up (b = À0Á0005, P = 0Á025). Conclusions There was a significant inverse association of baseline 25(OH)D with incident MetS, which may be partly driven by its association with glucose homoeostasis.

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The relationship of vitamin D with non-traditional risk factors for cardiovascular disease in subjects with metabolic syndrome

Cited by 26 publications

References 37 publications

Vitamin D Status Is Related to Oxidative Stress But Not High-Sensitive C-Reactive Protein in Women with Pre-Eclampsia

Vitamin D Status Is Related to Oxidative Stress But Not High-Sensitive C-Reactive Protein in Women with Pre-Eclampsia

The Ratio of Parathyroid Hormone to Vitamin D Is a Determinant of Cardiovascular Risk and Insulin Sensitivity in Adolescent Girls

Prospective association of 25(OH)D with metabolic syndrome

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