Vitamin D Status Is Related to Oxidative Stress But Not High-Sensitive C-Reactive Protein in Women with Pre-Eclampsia

Gargari, Bahram Pourghassem; Tabrizi, Fatemeh Pourteymour Fard; Sadien, Bita; Jafarabadi, Mohammad Asghari; Farzadi, Laya

doi:10.1159/000441781

Cited by 12 publications

(14 citation statements)

References 38 publications

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“…The results of current study correlates with what was found in (37) as there was no association between vitamin D deficiency and an active of protein C stimulation. Vitamin D affects the stimulation of T & B lymphocytes and regulates the immune system (12) .…”

Section: Concentration Of C-reactive Proteinsupporting

confidence: 91%

Hematological and Immunological Parameters Associated with Vitamin D Deficiency in Pregnant Women

Hilal¹,

Al-Ani²,

Hamid³

2019

JUAPS

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The aim of the study is to follow up a number of biochemical, immunological and physiological changes associated with vitamin D deficiency in pregnant women. 50 samples were collected from pregnant women, 50 from control group and 50 from non-pregnant women. A number of laboratory tests were carried out on the withdrawn blood samples. These tests examined the ELISA to measure vitamin D concentration. The concentration of vitamin D in the pregnant women group, control group and the non-pregnant women group (26.31,43.97,50.9) were found to be Nano mole / L respectively, indicating a decrease in vitamin D concentration in pregnant women compared to the control group. The results of the present study showed a significant decrease in the volume of the red blood cells in the three studied groups at the probability level P <0.05 where the average ratio of the volume of the red blood cells in the group of pregnant women and control group and the group of non-pregnant women was (40.0, 39.7,37.3 ) % respectively. The results of the comparison between the two groups showed no significant differences in the size of the size of the red blood cells in the three studied groups at the probability level P <0.05. The results of the statistical analysis showed significant differences in the blood platelet counts in the three studied groups at the P <0.05 level. The mean number of the blood platelet counts in the pregnant women group, control group and the non-pregnant women group were ( 222, 237,208) X1000/mm 3 respectively. Comparison between the two groups showed no significant differences in the number of thrombocytes in the three studied groups at the probability level P <0.05.The results of the statistical analysis showed a significant increase in the number of white blood cells in the blood of pregnant women and non-pregnant women at the probability level P <0.05 compared to the control group and the average number of white blood cells in the pregnant women group, control group and the group of non-pregnant women (35.0, 9.08, 10.6 ) cell/mm 3 respectively. A significant decrease in the IgE concentrations in the three studied groups at the level of probability P <0.05 and the average IgE concentration in pregnant women's blood and control and non-pregnant women (82.20,90.6, 79.8) U / L respectively, where no significant differences between the three studied groups at the probability level P <0.05. In the case of CRP, the results of the effective C test in the serum of the three studied groups showed that all samples had a negative result. As for the results of the blood components, there was a significant decrease in the concentration of hemoglobin in the blood of pregnant women and non-pregnant women compared to control group at the level of probability P <0.05 where the concentration of hemoglobin in the group of pregnant women and control group and the group of non-pregnant women (11.6,12.8,8.4) mm / 1hour, respectively, where the results of the comparison between the two averages showed significant differences between the ...

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Section: Concentration Of C-reactive Proteinsupporting

confidence: 91%

Hematological and Immunological Parameters Associated with Vitamin D Deficiency in Pregnant Women

Hilal¹,

Al-Ani²,

Hamid³

2019

JUAPS

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“…Similar to our data the findings of a trial showed that vitamin D supplementation had no effect on OS biomarkers among pregnant women with GDM [ 55 ]. However, there are some evidence that support a positive association between TAC and vitamin D status [ 41 , 65 ]. The findings of a systematic review of clinical trials among non-pregnant participants revealed that vitamin D only with doses of 100,000–200,000 IU/month could have beneficial effect on the OS parameters (decreases MDA levels and increases GSH and TAC levels) [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the efficacy of two doses of vitamin D supplementation on glycemic, lipidemic and oxidative stress biomarkers during pregnancy: a randomized clinical trial

Motamed

Nikooyeh

Kashanian

et al. 2020

BMC Pregnancy Childbirth

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Background Vitamin D deficiency during pregnancy is common and is likely to be associated with metabolic complications in the mother. The aim of this study was to assess the efficacy of two doses of vitamin D supplementation during pregnancy on maternal and cord blood vitamin D status and metabolic and oxidative stress biomarkers. Methods The eligible pregnant women (n = 84) invited to participate in the study and randomly allocated to one of the two supplementation groups (1000 IU/d vitamin D and 2000 IU/d). Biochemical assessments of mothers including serum concentrations of 25(OH)D, calcium, phosphate, iPTH, fasting serum sugar (FBS), insulin, triglyceride, total cholesterol, LDL-C, HDL-C, malondialdehyde (MDA) and total antioxidant capacity (TAC) were done at the beginning and 34 weeks of gestation. Cord blood serum concentrations of 25(OH)D, iPTH, MDA and TAC were assessed at delivery as well. To determine the effects of vitamin D supplementation on metabolic markers 1-factor repeated-measures analysis of variance (ANOVA) was used. Between groups comparisons was done by using Independent-samples Student’s t-test or Mann-Whitney test. P < 0.05 was considered as significant. Results Supplementation with 1000 IU/d and 2000 IU/d vitamin D resulted in significant changes in vitamin D status over pregnancy (24.01 ± 21.7, P < 0.001 in 1000 IU/d group and 46.7 ± 30.6 nmol/L, P < 0.001 in 2000 IU/d group). Daily intake of 2000 compared with 1000 IU/d tended to increase the serum concentration of HDL-C (10 ± 8.37, P < 0.001 in 1000 IU/d group and 9.52 ± 11.39 mg/dL, P < 0.001 in 2000 IU/d group). A significant decrement in serum concentration of iPTH observed in both groups (− 4.18 ± 7.5, P = 0.002 in 1000 IU/d group and − 8.36 ± 14.17, P = 0.002 in 2000 IU/d group). Conclusions Supplementation with 2000 IU/d vitamin D as compared with 1000 IU/d, is more effective in promoting vitamin D status and HDL-C serum concentration and in decreasing iPTH over pregnancy. Trial registration This trial is registered at clinicaltrials.gov (NCT03308487). Registered 12 October 2017 ‘retrospectively registered’.

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“…In common with many other inflammatory diseases (145), Vitamin D 3 levels [usually measured as 25(OH)vitD or calcidiol] are often lower in PE (990–994) [cf. Ref.…”

Section: Metabolomic Biomarkersmentioning

confidence: 99%

A Dormant Microbial Component in the Development of Preeclampsia

Kell

Kenny

2016

Front. Med.

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Preeclampsia (PE) is a complex, multisystem disorder that remains a leading cause of morbidity and mortality in pregnancy. Four main classes of dysregulation accompany PE and are widely considered to contribute to its severity. These are abnormal trophoblast invasion of the placenta, anti-angiogenic responses, oxidative stress, and inflammation. What is lacking, however, is an explanation of how these themselves are caused. We here develop the unifying idea, and the considerable evidence for it, that the originating cause of PE (and of the four classes of dysregulation) is, in fact, microbial infection, that most such microbes are dormant and hence resist detection by conventional (replication-dependent) microbiology, and that by occasional resuscitation and growth it is they that are responsible for all the observable sequelae, including the continuing, chronic inflammation. In particular, bacterial products such as lipopolysaccharide (LPS), also known as endotoxin, are well known as highly inflammagenic and stimulate an innate (and possibly trained) immune response that exacerbates the inflammation further. The known need of microbes for free iron can explain the iron dysregulation that accompanies PE. We describe the main routes of infection (gut, oral, and urinary tract infection) and the regularly observed presence of microbes in placental and other tissues in PE. Every known proteomic biomarker of “preeclampsia” that we assessed has, in fact, also been shown to be raised in response to infection. An infectious component to PE fulfills the Bradford Hill criteria for ascribing a disease to an environmental cause and suggests a number of treatments, some of which have, in fact, been shown to be successful. PE was classically referred to as endotoxemia or toxemia of pregnancy, and it is ironic that it seems that LPS and other microbial endotoxins really are involved. Overall, the recognition of an infectious component in the etiology of PE mirrors that for ulcers and other diseases that were previously considered to lack one.

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Vitamin D Status Is Related to Oxidative Stress But Not High-Sensitive C-Reactive Protein in Women with Pre-Eclampsia

Cited by 12 publications

References 38 publications

Hematological and Immunological Parameters Associated with Vitamin D Deficiency in Pregnant Women

Hematological and Immunological Parameters Associated with Vitamin D Deficiency in Pregnant Women

Evaluation of the efficacy of two doses of vitamin D supplementation on glycemic, lipidemic and oxidative stress biomarkers during pregnancy: a randomized clinical trial

A Dormant Microbial Component in the Development of Preeclampsia

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