The Ratio of Parathyroid Hormone to Vitamin D Is a Determinant of Cardiovascular Risk and Insulin Sensitivity in Adolescent Girls

Stanley, Takara L.; Bredella, Miriam A.; Pierce, Lisa; Misra, Madhusmita

doi:10.1089/met.2012.0102

Cited by 20 publications

(12 citation statements)

References 43 publications

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“…Previous studies have suggested an association of integrated assessment of vitamin D/PTH with glucose metabolism (41,42). Specifically, in a cross-sectional analysis evaluating 15 obese girls and 15 matched control subjects, Stanley et al (41) demonstrated that the ratio of PTH to vitamin D was associated with insulin sensitivity and hsCRP.…”

Section: Discussionmentioning

confidence: 99%

Prospective Associations of Vitamin D Status With β-Cell Function, Insulin Sensitivity, and Glycemia: The Impact of Parathyroid Hormone Status

et al. 2014

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Previous studies have yielded conflicting findings on the relationship between low vitamin D (25-OH-D) and impaired glucose homeostasis. In this context, we hypothesized that combined assessment of 25-OH-D with its regulator parathyroid hormone (PTH) may be required for optimal evaluation of the impact of vitamin D status on glucose metabolism. Thus, we evaluated the prospective associations of 25-OH-D and PTH at 3 months postpartum with b-cell function (Insulin SecretionSensitivity Index-2 [ISSI-2]), insulin sensitivity (Matsuda index), and glycemia at 12 months postpartum in 494 women undergoing serial metabolic characterization. Notably, 32% of those with prediabetes/diabetes mellitus at 12 months postpartum had both vitamin D deficiency and PTH in the highest tertile at 3 months postpartum. On multiple-adjusted linear regression analyses, vitamin D deficiency/insufficiency with PTH in the highest tertile at 3 months independently predicted poorer b-cell function (P = 0.03) and insulin sensitivity (P = 0.01) and increased fasting (P = 0.03) and 2-h glucose (P = 0.002) at 12 months postpartum. In contrast, vitamin D deficiency/insufficiency with lower PTH did not predict these outcomes. In conclusion, only vitamin D deficiency/insufficiency with increased PTH is an independent predictor of b-cell dysfunction, insulin resistance, and glycemia, highlighting the need for consideration of the PTH/25-OH-D axis when studying the impact of vitamin D status on glucose homeostasis.

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Section: Discussionmentioning

confidence: 99%

Prospective Associations of Vitamin D Status With β-Cell Function, Insulin Sensitivity, and Glycemia: The Impact of Parathyroid Hormone Status

et al. 2014

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“…OH)D in monitoring of maternal vitamin D status, although further research is needed to clarify the validity and utility of free 25(OH)D in reflecting tissue-specific activities or overall status of vitamin D. Third, parathyroid hormone (PTH), known for its synergistic role with vitamin D endocrine system,31 was not measured. Emerging evidence has also suggested the potential effects of an interaction between vitamin D and PTH on glucose metabolism 47,48. Lastly, because of a lack of information on determinants of vitamin D levels such as sun exposure or outdoor activities, residual confounding from them cannot be completely ruled out.In conclusion, our results suggest that early-pregnancy vitamin Ddeficiency may increase the risk of developing GDM in pregnant women.…”

mentioning

confidence: 99%

Vitamin D status during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study in a multiracial cohort

Jin

Song

Rawal

et al. 2019

Diabetes Obesity Metabolism

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Aim: To prospectively and longitudinally investigate vitamin D status during early to mid-pregnancy in relation to gestational diabetes mellitus (GDM) risk. Methods: In a nested case-control study of 107 GDM cases and 214 controls within the Fetal Growth Studies-Singleton Cohort, plasma levels of 25-hydroxyvitamin D2 and D3 (25(OH)D) and vitamin D binding protein were measured at gestational weeks 10 to 14, 15 to 26, 23 to 31, and 33 to 39; we further calculated total, free, and bioavailable 25(OH)D. Conditional logistic regression models and linear mixedeffects models were used. Results: We observed a threshold effect for the relation of vitamin D biomarkers with GDM risk. Vitamin D deficiency (<50 nmol/L) at 10 to 14 gestational weeks was associated with a 2.82-fold increased risk for GDM [odds ratio (OR) = 2.82, 95% confidence interval (CI): 1.15-6.93]. Women with persistent vitamin D deficiency at 10 to 14 and 15 to 26 weeks of gestation had a 4.46-fold elevated risk for GDM compared with women persistently non-deficient (OR = 4.46, 95% CI: 1.15-17.3).Conclusions: Maternal vitamin D deficiency as early as the first trimester of pregnancy was associated with an elevated risk of GDM. The association was stronger for women who were persistently deficient through the second trimester. Assess-

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“…These possibilities have prompted the inclusion of PTH measurements in clinical investigations of vitamin D status in patients with dysmetabolism (11).…”

mentioning

confidence: 99%

PTH-Vitamin D-Glycemia Interactions Reloaded

Lee

2014

Diabetes

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The Ratio of Parathyroid Hormone to Vitamin D Is a Determinant of Cardiovascular Risk and Insulin Sensitivity in Adolescent Girls

Cited by 20 publications

References 43 publications

Prospective Associations of Vitamin D Status With β-Cell Function, Insulin Sensitivity, and Glycemia: The Impact of Parathyroid Hormone Status

Prospective Associations of Vitamin D Status With β-Cell Function, Insulin Sensitivity, and Glycemia: The Impact of Parathyroid Hormone Status

Vitamin D status during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study in a multiracial cohort

PTH-Vitamin D-Glycemia Interactions Reloaded

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