Prospective association of 25(OH)D with metabolic syndrome

Abstract

SummaryContext Vitamin D may play a role in the aetiology of the metabolic syndrome (MetS), yet the majority of previous studies have been cross-sectional, and the limited number of prospective studies has yielded inconsistent results. Objective To examine the prospective association of vitamin D [25-hydroxyvitamin D, 25(OH)D] with MetS in a multi-ethnic cohort of adults in Ontario, Canada. Design Nondiabetic individuals with pre-existing MetS risk factors were recruited for participation in the PROspective Metabolism and ISlet cell Evaluation (PROMISE) cohort study, a longitudinal study of the determinants of insulin resistance and MetS. Methods Of the 654 participants enrolled at baseline, 489 attended a 3-year follow-up visit. There were 301 participants eligible for the analysis of 25(OH)D with incident MetS (age 49Á2 AE 9Á3 years old, 75Á4% female), after excluding 188 (38Á5%) prevalent MetS cases at baseline. Longitudinal change in MetS components was assessed in the entire follow-up cohort. Results There were 76 (15Á5%) participants who developed MetS over the 3-years of follow-up. Multivariate logistic regression analyses indicated a decreased risk of MetS at follow-up per standard deviation increase in baseline 25(OH)D after adjustment for sociodemographics, season, baseline and change in supplement use and physical activity and insulin resistance (OR = 0Á63, 95% CI 0Á44-0Á90). Multivariate linear regression analyses revealed a significant inverse association of baseline 25(OH)D with fasting glucose at follow-up (b = À0Á0005, P = 0Á025). Conclusions There was a significant inverse association of baseline 25(OH)D with incident MetS, which may be partly driven by its association with glucose homoeostasis.

Vitamin D levels in a large Mediterranean cohort: reconsidering normal cut-off values

“…82,89,90 Another finding, which further corroborated the in-verse correlation of 25-(OH)D with metabolic disease/ diabetes in our analysis, was the negative association between 25-(OH)D levels and HbA1c values. This inverse association is supported by other published reports 20,[91][92][93] and the seasonal variation of 25-(OH) D levels is inversely mirrored by HbA1c, with the lowest levels observed in the summer. 94 Indeed, low levels of 25-(OH)D are considered a risk factor for the development of insulin resistance and diabetes, 4,95 although the preventive effect of VitD supplementation has not yet been fully established.…”

Association of the Metabolic Syndrome and Vitamin D Receptor Gene Polymorphisms: A Cross Sectional Study

“…The Metabolic syndrome risk was significantly higher in subjects with very low serum vitamin D in the first (< 18 ng/mL) as well as second (18-23 ng/mL) quintiles [OR = 1.41 (95%CI: 1.02-1.95) and 1.74 (95%CI:1.28-2.37) respectively]. Similar study carried out by Kayaniyil et al (2014), on a multi-ethnic cohort of nondiabetic adults with pre-existing risk factors in Ontario, Canada; prospective association of serum vitamin D was reported with the metabolicsyndrome.489 subjects with MetSyn were monitored over a 3-year follow-up period. After adjustment for sociodemographics, including baseline and change in supplement use, season, physical activity and insulin resistance; multivariate logistic regression analyses was revealed a decreased risk of the metabolic syndrome per standard deviation increase in baseline 25(OH)D (OR = 0.63,95%CI: 0.44-0.90) (Gagnon et al, 2012).…”

Study of vitamin D3 level in patients with diabetes mellitus

“…[5] In a longitudinal study of the determinants of insulin resistance and the metabolic syndrome, a significant inverse association of baseline vitamin D 3 with incident Metabolic Syndrome, which may be partly association with glucose homeostasis. [14] In a study involving 8421 participants from the National Health and Nutrition Examination Survey III (NHANES III) of the noninstitutionalized civilian U.S. population, was observed significantly lower levels of vitamin D 3 in the subjects with metabolic syndrome than in those without it. [20] Vitamin D 3 facilitates the secretion of insulin from pancreatic beta cells, thus appearing to regulate insulin secretion and therefore vitamin D 3 deficiency may be related to impaired insulin secretion in the diabetes mellitus type 2.…”

“…[13] Vitamin D has been shown to be related to glucose metabolism and the development of diabetes mellitus type 2 and the metabolic syndrome. [14] Gene IJBAR (2016) 07 (07) www.ssjournals.com polymorphisms of vitamin D 3 receptor found to be related to components of the metabolic syndrome. [15] Moreover, vitamin D 3 seems to affect glucose homeostasis, vitamin D 3 levels having been found to be inversely related to glycosylated hemoglobin levels in gestational diabetes mellitus.…”