The relationship between vitamin D and parathyroid hormone: calcium homeostasis, bone turnover, and bone mineral density in postmenopausal women with established osteoporosis

Sahota, Opinder; Mundey, M K; San, P.; Godber, Ian M; Lawson, Nigel; Hosking, David J.

doi:10.1016/j.bone.2004.02.003

Cited by 227 publications

(176 citation statements)

References 30 publications

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“…The explanation for the impaired PTH response is not readily apparent. This blunted PTH response may protect against bone loss through decreased bone turnover, but is often associated with a disruption in calcium homeostasis as compared to patients with 25OHD insufficiency and secondary hyperparathyroidism (Sahota et al, 2004). Dysfunction of the parathyroid glands may be a possible explanation, including abnormal parathyroid calcium-sensing receptors or abnormal 1,25(OH) 2 D receptors, although these were not assessed in this study.…”

Section: Discussionmentioning

confidence: 90%

Vitamin D insufficiency in older female community-dwelling acute hospital admissions and the response to supplementation

et al. 2006

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Objectives: A significant proportion of the older population may exhibit vitamin D insufficiency. We sought to establish the proportion of 25-hydroxyvitamin D (25OHD) insufficient individuals in an older female cohort presenting for acute medical admission and how they responded to supplementation. Design: A prospective cohort study. Setting: Hospital admissions followed up as a population-based study. Subjects: A total of 114 consecutive female acute medical admissions aged over 65 years from November 2003 to January 2004 were enrolled. All admissions with hypercalcaemia, metabolic bone disease (other than osteoporosis/osteomalacia) and creatinine 4150 mmol/l were excluded. Interventions: iPTH, calcium and 25OHD levels were measured in each patient. Of the total, 22 were already receiving calcium and vitamin D supplementation at enrolment. The remaining 92 were commenced on 800 IU of vitamin D and 1 g calcium, and levels were reassessed after supplementation for 3 months. Results: 25-Hydroxyvitamin D insufficiency, as defined by a 25OHD concentration of o50 nmol/l, was present in 86 (75.4%) patients at initial assessment (mean 35.8 nmol/l, s.d. 23.3). Secondary hyperparathyroidism was present in only 36.7% of those with 25OHD deficiency at baseline. Of the total, 51 (44.7%) patients presented for follow-up. 25-Hydroxyvitamin D concentration increased in this group from 42.1 nmol/l (s.d. 26.6) to 59.5 nmol/l (s.d. 27.4) after supplementation, Po0.001, but 18(35.3%) still remained deficient. There was no significant change in iPTH or calcium following supplementation. Assessment of compliance revealed 6 (11.7%) admitted to partial or non-compliance. Conclusions: Insufficiency of 25OHD was very common in this cohort. Despite calcium and vitamin D supplementation, 25OHD concentrations failed to reach normality in a significant proportion. Maintaining vitamin D and calcium intake at the level of current recommended doses may not be sufficient to ensure adequate 25OHD stores.

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Section: Discussionmentioning

confidence: 90%

Vitamin D insufficiency in older female community-dwelling acute hospital admissions and the response to supplementation

et al. 2006

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“…Some studies found no relationship between plasma levels of 25OHD and 1,25(OH) 2 D (15-17), while other studies have shown either a positive (7)(8)(9)(10)(11)18) or an inverse association (19)(20)(21). Similar, discrepant results have been reported on the effect of treatment with ergo-or cholecalciferol on P-1,25(OH) 2 D levels.…”

Section: Discussionmentioning

confidence: 94%

Plasma 1,25(OH)2D levels decrease in postmenopausal women with hypovitaminosis D.

Rejnmark¹,

Vestergaard²,

Heickendorff

et al. 2008

European Journal of Endocrinology

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Objective: Although calcitriol (1,25(OH) 2 D) is considered the biologically active vitamin D metabolite, several studies have shown that calcidiol (25OHD) is the vitamin D metabolite that is most closely linked to parathyroid function and indices of calcium homeostasis. Moreover, low levels of 25OHD have been associated with increased risk of different diseases including cancer, diabetes, and myopathy. Design: Cross-sectional study. Methods: We studied relations between plasma concentrations of 25OHD, 1,25(OH) 2 D, and parathyroid hormone (PTH) in fasting plasma samples from 315 healthy postmenopausal women randomly selected from the local background population. Results: P-1,25(OH) 2 D levels varied in a concentration-dependent manner with P-25OHD levels (P!0.001). Thus, P-1,25(OH) 2 D levels were the lowest in women with vitamin D insufficiency, i.e., P-1,25(OH) 2 D levels were reduced by approximately one-third in subjects with P-25OHD levels below 25 nmol/l compared with levels above 80 nmol/l (P!0.01). The association was most pronounced at P-25OHD concentrations below 80 nmol/l, whereas no major increase in P-1,25(OH) 2 D was observed at P-25OHD concentrations above 80 nmol/l. In multiple regression analysis, PTH was a minor although significant predictor of P-1,25(OH) 2 D levels. Conclusions: In normal postmenopausal women, the conversion of 25OHD to active vitamin D depends on the substrate concentration. Our data support that vitamin D insufficiency should be considered at P-25OHD levels below 80 nmol/l.European Journal of Endocrinology 158 571-576

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“…In the study of Driel et al (2006) conducted in order to investigate the autocrine/paracrine function of 1α, 25-OH-D 3 , it was determined that 1α-hy-droxylase is expressed in the human osteoblasts, and also there are megalin and cubilin protein receptors bound to vitamin D. It was observed that osteoblasts produced 1α, 25-(OH)2D 3 , and ALP and osteocalcin expressions increased mildly with the addition of 25-OH-D 3 as a substrate to the osteoblast cell cultures while it did not have any effect on Ca and parathyroid hormone regulation. In the studies conducted on humans, 25-OH-D 3 showed a relation with osteoporosis, 25-OH-D 3 levels were observed to be low in patients with osteoporosis, while the parathormone levels were high (Sahota et al 1999, Sahota et al 2004, Garneo et al 2007). The vitamin D metabolism in dogs was mostly investigated in the pathological cases of kidney failure (Galler et al 2011).…”

Section: Discussionmentioning

confidence: 98%

Investigation of the bone metabolism in dogs with leishmaniasis

Ari¹,

Bildik²,

Ertuğ³

2017

Polish Journal of Veterinary Sciences

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The present study was aimed at determining bone metabolism related changes in dogs with visseral leishmaniasis such as vitamin D, calcium, phosphate and ALP levels as compared to healthy ones. A total of 40 serums of male dogs aged between 4 and 6 years that were sent to Adnan Menderes University, Faculty of Medicine, Parasitology Laboratory from Kuşadasy and Bodrum districts between the years 2012 and 2013, suspected with leishmaniasis, by the veterinary physicians in accordance with the cold chain rules and 20 of which were evaluated as leishmania seropositive and 20 as leishmania seronegative by the IFA test, were included in this study. There was no any statistically significant difference between the serum 25-OH-D 3 levels of Leishmania positive and negative dogs (p>0.05). There was a statistically significant difference between the serum ALP (p<0.05), and P levels were observed to be higher in the seropositive dogs than in the seronegative dogs, while Ca level was low (p<0.001).

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The relationship between vitamin D and parathyroid hormone: calcium homeostasis, bone turnover, and bone mineral density in postmenopausal women with established osteoporosis

Cited by 227 publications

References 30 publications

Vitamin D insufficiency in older female community-dwelling acute hospital admissions and the response to supplementation

Vitamin D insufficiency in older female community-dwelling acute hospital admissions and the response to supplementation

Plasma 1,25(OH)2D levels decrease in postmenopausal women with hypovitaminosis D.

Investigation of the bone metabolism in dogs with leishmaniasis

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