The relationship between serum levels of CA 125 and the degree of differentiation in ovarian neoplasms

Abstract

Introduction: Primary ovarian neoplasms exhibit a wide range of histopathological aspects, and tumors with epithelial differentiation are the most frequent. Among the malignant tumors, the most common histological type corresponds to serous adenocarcinoma, whose diagnosis is established in advanced stages of the disease in approximately 75% of the patients. Tumor marker CA 125 represents a glycoprotein synthesized mainly by neoplastic cells with epithelial differentiation, and its serum level seems to be associated with the biological potential of these lesions. Objective: To estimate the association between serum levels of CA 125 and the degree of differentiation in primary ovarian neoplasms.

Principais marcadores tumorais de câncer de mama: revisão da literatura

“…Qualquer alteração no nível de CA15-3 é usada para detectar doença metastática em aproximadamente 70% dos pacientes assintomáticos. [19][20][21] Já o antígeno tumoral 27.29 é encontrado no sangue de pacientes de câncer de mama, porém sem sensibilidade e especificidade suficientes para ser utilizado como um teste diagnóstico isolado. Esse é indicado para detectar o câncer de mama recorrente e acompanhamento de tratamento avançado.…”

Diagnostic Added-Value of Serum CA-125 on the IOTA Simple Rules and Derivation of Practical Combined Prediction Models (IOTA SR X CA-125)

“…The higher proportions of patients with borderline tumors in that study in comparison to our study (21.5% vs. 10.3%) might partially explain the difference in CA-125 performance. Other tumor characteristics may also affect the discriminative ability of serum CA-125, such as the histologic grades, the presence of extraovarian invasions, and the proportion of patients with early-stage ovarian cancer [ 34 ]. Another important point raised by the authors was that other ultrasound predictors (e.g., presence of ascites, maximum tumor diameter, and maximum diameter of solid component) included within the model were significantly more informative than serum CA-125 in characterizing adnexal tumors [ 32 ].…”

Salivary Lactate Dehydrogenase, C-Reactive Protein, and Cancer Antigen 125 Levels in Patients with Oral Lichen Planus and Oral Squamous Cell Carcinoma

“…The hydrophilic nature of mucin proteins provides them with the ability to form protective and lubricating barriers to protect against foreign particles and infectious agents. Serum CA125 levels increase in ovarian, lung, breast, and colorectal cancers (8,9,27).…”

“…This glycoprotein is a surface antigen in epithelial cells. Serum CA125 levels are increased in ovarian, lung, breast, and colorectal cancers; therefore, it is often used to diagnose or track recurrences of cancers (8,9).…”