The regulative effect and repercussion of probiotics and prebiotics on osteoporosis: involvement of brain-gut-bone axis

Fecal microbiota transplantation ameliorates bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and metabolic function

“…As an indispensable part of OP, the bone health and PMOP of middle-aged and elderly women is of particular concern [ 41 ]. Currently, accumulating evidence suggests that GM dysbiosis is involved in the pathogenesis and clinical manifestations of PMOP [ 19 , 42 ]. In this current study, our data suggested that FMT treatment could reshape the status of GM and ameliorate the bone loss in mice with OVX-induced OP.…”

“…During this process, the metabolites of intestinal pathogenic bacteria can enter the body through the damaged intestinal mucosal barrier, further trigger the immune response mediated by CD4+T cells and generate the pro-osteoclastogenic cytokines, and ultimately promote the activation of osteoclasts, which further highlights the existence and significance of GM-bone axis [ 17 ]. Moreover, in our previous critical reviews, based on the concept of “brain-gut-bone” axis, we have also summarized the modulatory effects and implication of GM to OP [ 18 ], as well as the regulative effects and repercussion of probiotics and prebiotics on OP [ 19 ]. Hence, in view of the close relationship between GM and bone metabolism, it is acknowledged that GM may can be regarded as a potential target for the prevention and treatment of OP to a certain extent.…”

NMR-Based Metabolomics to Decipher the Molecular Mechanisms in the Action of Gut-Modulating Foods

“…Among the potential gut-organ axes, the existence of a gut-bone axis has recently received increasing attention [ 55 ]. The gut-bone axis is interesting, since it may unlock how food and food components exert effects on bone health in more ways than by providing calcium and other relevant building bricks of bone tissue.…”

The effects and significance of gut microbiota and its metabolites on the regulation of osteoarthritis: Close coordination of gut-bone axis

“…In recent years, more and more researches have suggested that the dysregulation of GM and its metabolites is not only involved in the pathogenic process of the intestinal diseases (such as inflammatory bowel disease, Crohn's disease, and colon cancer), but also the imbalance of intestinal homeostasis may induce several extraintestinal immune and metabolic diseases (such as osteoporosis, psoriasis, systemic lupus erythematosus, and OA) (16)(17)(18)(19)(20)(21). Regarding this, Sheth et al (22) showed that approximately 10-40% of patients with inflammatory bowel disease may suffer from at least one extraintestinal lesion, with the most frequent occurrences being musculoskeletal lesions, such as OA and osteoporosis.…”