NMR-Based Metabolomics to Decipher the Molecular Mechanisms in the Action of Gut-Modulating Foods

He, Weiwei; Bertram, Hanne Christine

doi:10.3390/foods11172707

Cited by 5 publications

(2 citation statements)

References 97 publications

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“…93−95 It is demonstrated that creatine and creatinine are also associated with mitochondrial muscle respiration, playing a regulation role in adipose tissue metabolism; 96,97 in particular, we can highlight that a potential effect of the probiotics on the protein metabolism is observed even at serum level. 98,99 The decrease of histidine could be directly related to bacterial fermentation; in fact, the gut microbiota converts histidine into an immunoregulatory signal, histamine, able to suppress pro-inflammatory tumor necrosis factor (TNF) production that could generate several local and/or systemic diseases. 78,100 It is also known that the gut microbiota utilizes glutamine as a nitrogen source for optimal survival and growth.…”

Section: ■ Discussionmentioning

confidence: 99%

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Exploring the Effects of Probiotic Treatment on Urinary and Serum Metabolic Profiles in Healthy Individuals

Di Cesare,

Calgaro,

Ghini

et al. 2023

J. Proteome Res.

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Probiotics are live microorganisms that confer health benefits when administered in adequate amounts. They are used to promote gut health and alleviate various disorders. Recently, there has been an increasing interest in the potential effects of probiotics on human physiology. In the presented study, the effects of probiotic treatment on the metabolic profiles of human urine and serum using a nuclear magnetic resonance (NMR)-based metabonomic approach were investigated. Twenty-one healthy volunteers were enrolled in the study, and they received two different dosages of probiotics for 8 weeks. During the study, urine and serum samples were collected from volunteers before and during probiotic supplementation. The results showed that probiotics had a significant impact on the urinary and serum metabolic profiles without altering their phenotypes. This study demonstrated the effects of probiotics in terms of variations of metabolite levels resulting also from the different probiotic posology. Overall, the results suggest that probiotic administration may affect both urine and serum metabolomes, although more research is needed to understand the mechanisms and clinical implications of these effects. NMR-based metabonomic analysis of biofluids is a powerful tool for monitoring host-gut microflora dynamic interaction as well as for assessing the individual response to probiotic treatment.

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Section: ■ Discussionmentioning

confidence: 99%

“…It is demonstrated that creatine and creatinine are also associated with mitochondrial muscle respiration, playing a regulation role in adipose tissue metabolism; 96 , 97 in particular, we can highlight that a potential effect of the probiotics on the protein metabolism is observed even at serum level. 98 , 99 …”

Section: Discussionmentioning

confidence: 99%

Exploring the Effects of Probiotic Treatment on Urinary and Serum Metabolic Profiles in Healthy Individuals

Di Cesare,

Calgaro,

Ghini

et al. 2023

J. Proteome Res.

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Highlights of three metabolites HDL and reduction in blood pressure values after dietary fiber supplementation in overweight and obese normotensive women: a metabolomic study

da Silva,

Monteiro,

Fechine

et al. 2023

Metabolomics

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Introduction The prevalence of hypertension and obesity are a worldwide concern. Objetives Assess the metabolites profile after intervention with mixed dietary fiber in overweight and obese normotensive women. Methods This is a randomized double blind placebo-controlled study. Through a simple randomization process, two groups were allocated, with eleven women (group 1) receiving 12 g of mixed dietary fiber and thirteen women (group 2) receiving 12 g of placebo (corn starch) for eight weeks. Anthropometric and biochemical tests and lifestyle were analyzed. As for evaluation metabolomics, used a 1H NMR. The data matrix generated 96 samples and 225 variables, which was exported in the ASCII format for the “The Unscrumbler” statistics software (version 9.7, CAMO Process). Results After the intervention with mixed dietary fiber, significant differences were observed between the main types of metabolites, referring to the increase in the relative peak areas of in three HDL metabolites 4.94 ppm (0.0086*), HDL 1.28 ppm (0 .0337*), HDL 0.88 ppm (0.0224*) and an α-glucose metabolite 4.90 ppm (0.0106) and the reduction in systolic blood pressure (SBP) (0.0292*) of 7 mmHg in the reference range and in the placebo group there was a reduction in SBP (0.0118*) of 4 mmHg and of a choline metabolite 3.65 ppm (0.0266*), which does not call into question the validity of these results in the literature. Conclusion The synergism of the functions of these statistically highlighted metabolites contributed to prevention the increase in SBP after fiber intervention in overweight and obese normotensive women.

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Cell-Free Supernatant of Lactobacillus rhamnosus and Bifidobacterium breve Ameliorates Ischemic Stroke-Generated Neurological Deficits in Rats

Rahman,

Padhy,

Dandekar

2024

Probiotics & Antimicro. Prot.

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NMR-Based Metabolomics to Decipher the Molecular Mechanisms in the Action of Gut-Modulating Foods

Cited by 5 publications

References 97 publications

Exploring the Effects of Probiotic Treatment on Urinary and Serum Metabolic Profiles in Healthy Individuals

Exploring the Effects of Probiotic Treatment on Urinary and Serum Metabolic Profiles in Healthy Individuals

Highlights of three metabolites HDL and reduction in blood pressure values after dietary fiber supplementation in overweight and obese normotensive women: a metabolomic study

Cell-Free Supernatant of Lactobacillus rhamnosus and Bifidobacterium breve Ameliorates Ischemic Stroke-Generated Neurological Deficits in Rats

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