Fecal microbiota transplantation ameliorates bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and metabolic function

Zhang, Yuan‐Wei; Cao, Mu-Min; Li, Yingjuan; Lu, Panpan; Dai, Guang-Chun; Zhang, Ming; Wang, Hao; Menemenlis, Dimitris

doi:10.1016/j.jot.2022.08.003

Cited by 27 publications

(13 citation statements)

References 72 publications

(80 reference statements)

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“…Wang et al [92] suggested that the dysbiosis of gut microbiota by transferring the feces from senile osteoporotic rats to young rats can induce osteoporosis, and the changed gut microbiota and impaired intestinal mucosal barrier contributed to the pathogenesis of osteoporosis. Zhang et al [93] also showed that FMT plays an active role in remodeling the gut microbiota and improving the bone loss in OVX-induced mice with osteoporosis. Specifically, by correcting imbalance of gut microbiota, improving the level of SCFAs, optimizing intestinal permeability and inhibiting release of pro-inflammatory cytokines, FMT inhibited the excessive generation of osteoclasts and obtained the balance between bone formation and bone absorption, thus ameliorating the bone loss in OVX-induced mice with osteoporosis.…”

Section: The Involvement Of Intestinal Mucosal Barriermentioning

confidence: 99%

Fecal microbiota transplantation as a promising treatment option for osteoporosis

Zhang

Cao

et al. 2022

J Bone Miner Metab

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Osteoporosis is a systemic metabolic bone disease characterized by the descending bone mass and destruction of bone microstructure, which tends to result in the increased bone fragility and associated fractures, as well as high disability rate and mortality. The relation between gut microbiota and bone metabolism has gradually become a research hotspot, and it has been verified that gut microbiota is closely associated with reduction of bone mass and incidence of osteoporosis recently. As a novel "organ transplantation" technique, fecal microbiota transplantation (FMT) mainly refers to the transplantation of gut microbiota from healthy donors to recipients with gut microbiota imbalance, so that the gut microbiota in recipients can be reshaped and play a normal function, and further prevent or treat the diseases related to gut microbiota disorder. Herein, based on the gut-bone axis and proven regulatory effects of gut microbiota on osteoporosis, this review expounds relevant basic researches and clinical practice of FMT on osteoporosis, thus demonstrating the potentials of FMT as a therapeutic option for osteoporosis and further providing certain reference for the future researches.

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Section: The Involvement Of Intestinal Mucosal Barriermentioning

confidence: 99%

Fecal microbiota transplantation as a promising treatment option for osteoporosis

Zhang

Cao

et al. 2022

J Bone Miner Metab

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“…Accordingly, fecal microbiota transplants (FMTs) protected recipients from osteoporosis as well. A reduced production of osteoclastic cytokines, such as TNF-alpha or IL-1beta, and an increase in SCFAs accompanied that protection [ 114 ]. Moreover, FMTs strengthened the intestinal barrier, as demonstrated by increased expression of tight junction proteins.…”

Section: The Bone As Frequent Target Of Extraintestinal Ibd Manifesta...mentioning

confidence: 99%

Pivotal Role of Intestinal Microbiota and Intraluminal Metabolites for the Maintenance of Gut–Bone Physiology

Grüner

Ortlepp

Mattner

2023

IJMS

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Intestinal microbiota, and their mutual interactions with host tissues, are pivotal for the maintenance of organ physiology. Indeed, intraluminal signals influence adjacent and even distal tissues. Consequently, disruptions in the composition or functions of microbiota and subsequent altered host–microbiota interactions disturb the homeostasis of multiple organ systems, including the bone. Thus, gut microbiota can influence bone mass and physiology, as well as postnatal skeletal evolution. Alterations in nutrient or electrolyte absorption, metabolism, or immune functions, due to the translocation of microbial antigens or metabolites across intestinal barriers, affect bone tissues, as well. Intestinal microbiota can directly and indirectly alter bone density and bone remodeling. Intestinal dysbiosis and a subsequently disturbed gut–bone axis are characteristic for patients with inflammatory bowel disease (IBD) who suffer from various intestinal symptoms and multiple bone-related complications, such as arthritis or osteoporosis. Immune cells affecting the joints are presumably even primed in the gut. Furthermore, intestinal dysbiosis impairs hormone metabolism and electrolyte balance. On the other hand, less is known about the impact of bone metabolism on gut physiology. In this review, we summarized current knowledge of gut microbiota, metabolites and microbiota-primed immune cells in IBD and bone-related complications.

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“…Yan et al [38] also reported that the colonization of GM in mice increased the rate of bone formation and length of femur, and detected the enhancement of serum insulin-like growth factor-1 (IGF-1) and bone formation marker (procollagen type I N-terminal propeptide (P1NP)), suggesting that the stimulation of bone formation through GM may be mediated by IGF-1. Zhang et al [39] showed that fecal microbiota transplantation (FMT) plays an active role in remodeling the GM and improving the bone loss in OVX-induced mice with OP. In details, by correcting imbalance of GM, improving the level of SCFAs, optimizing the intestinal permeability and inhibiting the release of pro-inflammatory cytokines, FMT may inhibit the excessive generation of osteoclasts and obtain the balance between bone formation and bone absorption, thus ameliorating the bone loss in OVX-induced mice with OP.…”

Section: The Inseparable Association Between Op and Gmmentioning

confidence: 99%

A narrative review of the moderating effects and repercussion of exercise intervention on osteoporosis: ingenious involvement of gut microbiota and its metabolites

Zhang

Cao

et al. 2022

J Transl Med

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Osteoporosis (OP) is a systemic bone disease characterized by the decreased bone mass and destruction of bone microstructure, which tends to result in the enhanced bone fragility and related fractures, as well as high disability rate and mortality. Exercise is one of the most common, reliable and cost-effective interventions for the prevention and treatment of OP currently, and numerous studies have revealed the close association between gut microbiota (GM) and bone metabolism recently. Moreover, exercise can alter the structure, composition and abundance of GM, and further influence the body health via GM and its metabolites, and the changes of GM also depend on the choice of exercise modes. Herein, combined with relevant studies and based on the inseparable relationship between exercise intervention-GM-OP, this review is aimed to discuss the moderating effects and potential mechanisms of exercise intervention on GM and bone metabolism, as well as the interaction between them.

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Fecal microbiota transplantation ameliorates bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and metabolic function

Cited by 27 publications

References 72 publications

Fecal microbiota transplantation as a promising treatment option for osteoporosis

Fecal microbiota transplantation as a promising treatment option for osteoporosis

Pivotal Role of Intestinal Microbiota and Intraluminal Metabolites for the Maintenance of Gut–Bone Physiology

A narrative review of the moderating effects and repercussion of exercise intervention on osteoporosis: ingenious involvement of gut microbiota and its metabolites

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