The rat closely mimics oxidative stress and inflammation in humans after exercise but not after exercise combined with vitamin C administration

Veskoukis, Aristidis S.; Γουτιάνος, Γεώργιος; Paschalis, Vassilis; Margaritelis, Nikos V.; Tzioura, Aikaterini; Δίπλα, Κωνσταντίνα; Zafeiridis, Andreas; Vrabas, Ioannis S.; Kyparos, Antonios; Nikolaidis, Michalis G.

doi:10.1007/s00421-016-3336-8

Cited by 21 publications

(11 citation statements)

References 82 publications

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“…However, in animal experiments, all kinds of biological tissues can be examined, and the effects of genetic and environmental factors can be eliminated to a greater extent than in human trials. Although human trials and animal experiments have their respective advantages and disadvantages, Veskoukis et al, have reported that exhaustive exercise at an intensity corresponding to 86% of maximum running speed resulted in approximately the same responses between humans and rats, in terms of oxidation products and antioxidant levels in blood plasma [ 65 ]. This suggests that results in rats sufficiently reflect the human oxidative stress response, at least in blood plasma.…”

Section: Exercise-induced Oxidative Stressmentioning

confidence: 99%

Exercise-Induced Oxidative Stress and the Effects of Antioxidant Intake from a Physiological Viewpoint

2018

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It is well established that the increase in reactive oxygen species (ROS) and free radicals production during exercise has both positive and negative physiological effects. Among them, the present review focuses on oxidative stress caused by acute exercise, mainly on evidence in healthy individuals. This review also summarizes findings on the determinants of exercise-induced oxidative stress and sources of free radical production. Moreover, we outline the effects of antioxidant supplementation on exercise-induced oxidative stress, which have been studied extensively. Finally, the following review briefly summarizes future tasks in the field of redox biology of exercise. In principle, this review covers findings for the whole body, and describes human trials and animal experiments separately.

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Section: Exercise-induced Oxidative Stressmentioning

confidence: 99%

Exercise-Induced Oxidative Stress and the Effects of Antioxidant Intake from a Physiological Viewpoint

2018

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“…Although the biological meaning was unknown, these results created a lot of interest over the following years about the role ROS plays during exercise. While acute exercise may induce a temporary state of oxidative stress, chronic physical activity promotes favorable oxidative adaptations [79]. Various modalities of regular exercising (endurance, resistance, or combined training) generally improve systemic markers of oxidative stress and antioxidant capacity in healthy individuals [80, 81], but its impact on oxidative stress in metabolic diseases is less clear.…”

Section: Effects Of Acute and Chronic Exercise On Oxidative Stress Inmentioning

confidence: 99%

The Janus Head of Oxidative Stress in Metabolic Diseases and During Physical Exercise

Pesta

Roden

2017

Curr Diab Rep

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Purpose of ReviewOxidative stress describes an imbalance between production and degradation of reactive oxygen species (ROS), which can damage macromolecules. However, ROS may also serve as signaling molecules activating cellular pathways involved in cell proliferation and adaptation. This review describes alterations in metabolic diseases including obesity, insulin resistance, and/or diabetes mellitus as well as responses to acute and chronic physical exercise.Recent FindingsChronic upregulation of oxidative stress associates with the development of insulin resistance and type 2 diabetes (T2D). While single bouts of exercise can transiently induce oxidative stress, chronic exercise promotes favorable oxidative adaptations with improvements in muscle mitochondrial biogenesis and glucose uptake.SummaryAlthough impaired antioxidant defense fails to scavenge ROS in metabolic diseases, chronic exercising can restore this abnormality. The different metabolic effects are likely due to variability of reactive species and discrepancies in temporal (acute vs. chronic) and local (subcellular distribution) patterns of production.

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“…basal levels of inflammatory cytokines (Ellulu et al 2015, Veskoukis et al 2016. Despite these limitations, to our knowledge, this is the first report showing the ability of a single dose of ascorbic acid to elicit anxiolytic effects in humans.…”

Section: Discussionmentioning

confidence: 96%

Effects of ascorbic acid on anxiety state and affect in a non-clinical sample

Moritz

Schwarzbold

Guarnieri

et al. 2017

Acta Neurobiologiae Experimentalis

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Objective Given that the literature data indicates that ascorbic acid may have an anxiolytic effect, we hypothesized that a single oral administration of ascorbic acid could acutely affect emotional states. Methods The effects of acid ascorbic supplementation on anxiety and other emotional states were evaluated by the State-Trait Anxiety Inventory (STAI), and Visual Analogue Mood Scale (VAMS). Immediately before, and 2 hours after receiving a single ascorbic acid dose (1000 mg) or placebo, 142 graduate students were evaluated by the STAI and VAMS in a randomized, double-blind, placebo-controlled trial. Results No changes from basal levels were observed in the STAI state-anxiety or VAMS scores. However, the ingestion of ascorbic acid by the 25% more anxious healthy subjects (women; 14 control and 23 ascorbic acid), as defined by the STAI trait-anxiety scale, produced a significant reduction from baseline anxiety scores in the STAI state-anxiety scale and VAMS anxiety subscale. The study evaluated a small sample with narrow sociodemographic characteristics, composed mainly of healthy young females (> 94%) enrolled in post-graduation courses, without controlling diet, physical activity, and formal psychiatric diagnosis. Conclusions: Despite the sample size limitation, this study provides the first evidence of an acute anxiolytic effect of ascorbic acid. Broader population studies are required to evaluate the clinical relevance of presented data.

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The rat closely mimics oxidative stress and inflammation in humans after exercise but not after exercise combined with vitamin C administration

Abstract: The rat adequately mimics human responses to exercise in basic blood redox/inflammatory profile, yet this is not the case after exercise combined with vitamin C administration.

Cited by 21 publications

References 82 publications

Exercise-Induced Oxidative Stress and the Effects of Antioxidant Intake from a Physiological Viewpoint

Exercise-Induced Oxidative Stress and the Effects of Antioxidant Intake from a Physiological Viewpoint

The Janus Head of Oxidative Stress in Metabolic Diseases and During Physical Exercise

Effects of ascorbic acid on anxiety state and affect in a non-clinical sample

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