Exercise-Induced Oxidative Stress and the Effects of Antioxidant Intake from a Physiological Viewpoint

Kawamura, Takanobu; Muraoka, Isao

doi:10.3390/antiox7090119

Cited by 228 publications

(224 citation statements)

References 141 publications

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“…In fact, the ingestion of antioxidant substances has been suggested to alleviate muscle damage as well as exercise-induced inflammation and oxidative stress [18,19]. In addition to conventional antioxidants, it has been suggested that molecular hydrogen (H 2 ) can act as an antioxidant.…”

Section: Introductionmentioning

confidence: 99%

Involvement of Neutrophil Dynamics and Function in Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness: Effect of Hydrogen Bath

et al. 2018

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The purpose of this study was to investigate the involvement of neutrophil dynamics and function in exercise-induced muscle damage (EIMD) and delayed-onset muscle soreness (DOMS), and the effect of molecular hydrogen (H2) intake on these parameters. Nine healthy and active young men performed H2 and placebo bath trial in a crossover design. They carried out downhill running (−8% slope) for 30 min at a speed corresponding to 75~85% of peak oxygen uptake (VO2peak). Subsequently, they repeated bathing for 20 min per day for one week. Degree of muscle soreness (visual analogue scale: VAS), peripheral leukocyte counts, neutrophil dynamics and function, muscle damage, and inflammation markers were measured. Plasma interleukin (IL)-6 concentration was significantly correlated with peripheral neutrophil count, VAS, and serum creatine kinase activity, respectively, after downhill running. Peripheral neutrophil count and serum myoglobin concentration were also significantly correlated. Conversely, there were no effects of H2 bath. These results suggest that IL-6 may be involved in the mobilization of neutrophils into the peripheral blood and subsequent EIMD and DOMS after downhill running; however, it is not likely that H2 bath is effective for the inflammatory process that is centered on neutrophils after downhill running.

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Section: Introductionmentioning

confidence: 99%

Involvement of Neutrophil Dynamics and Function in Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness: Effect of Hydrogen Bath

et al. 2018

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“…The moderate-intensity exercise illustrated systemic and complex health-promoting effects through the regulation and signaling of redox homeostasis [32]. The balance of oxidative stress and antioxidative capacity during high-intensity exercise is important for physiological adaptation [33]. Oxidative stress, contingent on endurance exercise duration and intensity, significantly elevates related indexes, such as oxidative markers (TBARS and protein carbonyl) and total antioxidant capacity [34].…”

Section: Discussionmentioning

confidence: 99%

Low-Osmolality Carbohydrate–Electrolyte Solution Ingestion Avoid Fluid Loss and Oxidative Stress after Exhaustive Endurance Exercise

Huang

Tung

et al. 2020

Antioxidants

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Low-osmolality carbohydrate–electrolyte solution (LCS) ingestion can replace losses from exercise-induced dehydration, but the benefits of LCS ingestion strategy after exhaustive endurance exercise (EEE) remain unknown. The present study evaluated the effects of LCS ingestion on dehydration, oxidative stress, renal function, and aerobic capacity after EEE. In our study with its double-blind, crossover, counterbalanced design, 12 healthy male participants were asked to consume LCS (150 mL four times per hour) or placebo (water) 1 h before and 1 h after EEE. All participants completed a graded exercise test to exhaustion on a treadmill for the determination of maximal oxygen consumption ( V ˙ O 2 max ), applied to further intensity calibration, and then completed the EEE test. The average heart rate, maximal heart rate, running time to exhaustion, and peak oxygen uptake (VO2peak) were recorded during the exercise period. The participants’ body weight was recorded at different time points before and after the EEE to calculate the dehydration rate. Blood samples were drawn at baseline and before, immediately after, 1 h after, and 2 h after EEE to determine indicators of oxidative stress and renal function. The results indicated that the dehydration rates in participants with LCS ingestion at 15 min, 30 min, and 45 min after EEE were significantly lower than in participants with placebo ingestion (−1.86 ± 0.47% vs. −2.24 ± 0.72%; −1.78 ± 0.50% vs. −2.13 ± 0.74%; −1.54 ± 0.51% vs. −1.94 ± 0.72%, respectively; p < 0.05). In addition, the concentration of catalase in participants with LCS ingestion immediately after EEE was significantly higher than in participants with placebo ingestion (2046.21 ± 381.98 nmol/min/mL vs. 1820.37 ± 417.35 nmol/min/mL; p < 0.05). Moreover, the concentration of protein carbonyl in participants with LCS ingestion immediately after EEE was slightly lower than in participants with placebo ingestion (2.72 ± 0.31 nmol carbonyl/mg protein vs. 2.89 ± 0.43 nmol carbonyl/mg protein; p = 0.06). No differences were noted for other variables. Our findings conclude that LCS ingestion can effectively avoid fluid loss and oxidative stress after EEE. However, LCS ingestion had no benefits for renal function or aerobic capacity.

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“…This recovery pattern is more significant when the animals were pre-treated followed by co-treated with methanolic extract administration. From laboratory investigations, it has been noted that swimming or exhaustive physical exercise results oxidative stress in general 34 by oxygen reperfusion 35 or by consumption of excess oxygen 36 that results tissue damage 37 .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2020

IJPSR

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Background: Zingiber officinalis known as ginger, under the family Zingiberaceae, is a popular food spice and occupies an important place in Ayurvedic and traditional medicine. Its rhizome is used as antioxidative, carminative and for chronic diseases. Aims: Study indicated the curative effects of methanolic extract of ginger on severe exercise-induced oxidative damage in vital organs. Materials and Methods: Oxidative stress was established in male rat by forced swimming in an acrylic plastic pool filled with water. The total duration of 8 h per day including rest was allowed for both the treated and untreated forced swimming group of animals. Oxidative stress has been observed by monitoring of SOD, CAT, GST and Px activities along with quantification of TBARS and CD levels in liver, cerebrum, testis, and plasma. Whether the applied dose has toxicity if any, general body weight parameter was assessed. Results: Results indicate that SOD, CAT, GST and Px activities were decreased along with increase in levels of TBARS and CD in aforesaid tissues significantly in forced swimming group which were corrected significantly after 15 days pre-treatment followed by 28 days co-treatment of methanolic extract at the concentration of 20 mg/0.5 ml olive oil/100 gm body weight/rat/day in forced swimming group of rats (p<0.05). The extract showed non-toxic effect reflected here from the study of percentage gain in body weight. Conclusion: This finding reveals that methanolic extract of rhizome of Zingiber officinalis exhibited significant protective and curative effects on vital tissues in swimming-induced oxidative stressed rats.

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Exercise-Induced Oxidative Stress and the Effects of Antioxidant Intake from a Physiological Viewpoint

Cited by 228 publications

References 141 publications

Involvement of Neutrophil Dynamics and Function in Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness: Effect of Hydrogen Bath

Involvement of Neutrophil Dynamics and Function in Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness: Effect of Hydrogen Bath

Low-Osmolality Carbohydrate–Electrolyte Solution Ingestion Avoid Fluid Loss and Oxidative Stress after Exhaustive Endurance Exercise

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