The predictive value of inflammatory and oxidative markers following the successful cardioversion of persistent lone atrial fibrillation

Leftheriotis, Dionyssios; Fountoulaki, Katerina; Flevari, Panayota; Parissis, John; Panou, Fotis; Andreadou, Ioanna; Venetsanou, K; Iliodromitis, Efstathios K.; Kremastinos, Dimitrios Th.

doi:10.1016/j.ijcard.2008.04.012

Cited by 68 publications

(36 citation statements)

References 40 publications

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“…In the present study, expression of NOX2, a membrane‐spanning subunit of NADPH oxidases, and NOX4, which is predominantly localized in the mitochondria, was significantly upregulated in LA tissue isolated from 5/6Nx rats, and the expression of MDA was concomitantly upregulated. Consistently, circulating levels of MDA were elevated in patients with AF 37. Furthermore, we confirmed that IS directly increased the expression of NOX2 and NOX4 accompanied by the increase of MDA in cultured atrial fibroblasts.…”

Section: Discussionsupporting

confidence: 81%

Role of Indoxyl Sulfate as a Predisposing Factor for Atrial Fibrillation in Renal Dysfunction

Aoki

Teshima

Kondo

et al. 2015

JAHA

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BackgroundRenal dysfunction is a major risk factor for atrial fibrillation (AF). The uremic toxin indoxyl sulfate may contribute to the progression of cardiac fibrosis and AF substrate in renal dysfunction.Methods and ResultsMale Sprague–Dawley rats were assigned randomly to the following groups: 5/6 nephrectomy (5/6Nx) with vehicle, 5/6Nx with AST‐120, sham procedure with vehicle, and sham procedure with AST‐120. Vehicle and AST‐120 were administered for 4 weeks. Serum levels of IS were significantly increased in 5/6Nx groups. Expression of malondialdehyde, an indicator of oxidative stress, was upregulated in the left atrium of 5/6Nx groups and was accompanied by an increase in expression of NADPH oxidase 2 and 4. Monocyte‐mediated inflammatory signals such as CD68, monocyte chemoattractant protein 1, and vascular cell adhesion molecule 1 were also upregulated in 5/6Nx groups. Interstitial fibrosis was promoted heterogeneously, and expression of profibrotic indicators such as transforming growth factor β1, α‐smooth muscle actin, and collagen type 1 was upregulated in left atrium tissue of 5/6Nx groups. In cultured atrial fibroblasts, incubation with IS upregulated expression of the markers of oxidative stress, inflammation, and profibrotic factors. These results suggest the direct effects of IS on the progression of AF substrate. AF was consistently and invariably induced by atrial extrastimuli in 5/6Nx groups in electrophysiological experiments. AST‐120 treatment significantly alleviated renal dysfunction–induced oxidative stress, inflammation, and atrial fibrosis and, consequently, attenuated AF inducibility.ConclusionsIndoxyl sulfate facilitates atrial fibrosis and AF and thus is a novel therapeutic target for prevention of renal dysfunction–induced AF.

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Section: Discussionsupporting

confidence: 81%

Role of Indoxyl Sulfate as a Predisposing Factor for Atrial Fibrillation in Renal Dysfunction

Aoki

Teshima

Kondo

et al. 2015

JAHA

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“…Studies have assessed markers of inflammation, myocardial injury, and atrial stretch with varying levels of success. (8)(9)(10)(11)(12)(13) A number of substances involved in fibrosis can be measured in peripheral blood and therefore have the potential to act as biomarkers. Evidence is conflicting regarding their use in rhythm control in general, and is sparse in the context of DCCV.…”

Section: Introductionmentioning

confidence: 99%

Circulating biomarkers of fibrosis and cardioversion of atrial fibrillation: A prospective, controlled cohort study

Begg

Lip

Plein

et al. 2017

Clinical Biochemistry

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“…3,4 However, very few are the studies investigating the oxidative status of AF patients during the rhythm disturbance and after sinus rhythm restoration. A study in dynamics could allow researchers to seek a strong correlation between changes in oxidative status and clinical manifestation of AF.…”

Section: Introductionmentioning

confidence: 99%

Paroxysmal Atrial Fibrillation: Dynamics of The Main Antioxidant Enzymes - Superoxide Dismutase and Catalase

Negreva¹,

Penev²,

Georgiev³

et al. 2014

Folia Medica

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INTRODUCTION:Researchers have a particularly strong interest in the mechanisms implicated in the clinical manifestation of atrial fi brillation. OBJECTIVE: To examine dynamically the activity of the antioxidant enzymes, superoxide dismutase and catalase in patients with paroxysmal atrial fi brillation (duration < 48 hours). MATERIALS AND METHODS: The studied parameters were examined in the erythrocytes of 51 patients (59.84 ± 1.60, 26 men) immediately after their hospitalization, at 24 hours and 28 days after restoration of sinus rhythm. 52 controls (59.50 ± 1.46, 26 men) were also included, none of which had a history of arrhythmia. Propafenone was used to manage the rhythm abnormality. The enzyme activity was determined by a spectrophotometric method. RESULTS: The average duration of atrial fi brillation episodes until the time of hospitalization was 8.14 hours (from 2 to 24 hours). During patient hospitalization the activity of superoxide dismutase and catalase was considerably higher compared to that of the controls (8.46 ± 0.26 vs 5.81 ± 0.14 U/mg Hb; 7.36 ± 0.25 vs 4.76 ± 0.12 E 240 /min/mg Hb; P < 0.001). This difference was maintained 24 hours after the rhythm regularization (7.19 ± 0.25 vs 5.81 ± 0.14 U/mg Hb, p < 0.001; 5.30 ± 0.21 vs 4.76 ± 0.12 E 240 /min/mg Hb, p < 0.05). Twenty-eight days after the restoration of sinus rhythm, the activity of catalase remained increased (5.11 ± 0.08 vs 4.76 ± 0.12 E 240 /min/mg Hb, p < 0.05). CONCLUSION: The paroxysmal atrial fi brillation in our study was characterized with signifi cantly increased activity of superoxide dismutase and catalase even in the early hours of clinical manifestation of the disorder, which then slowly decreased with the restoration of sinus rhythm. Therefore, we can conclude that changes in oxidative status are closely related to the disease and are probably a part of the intimate mechanisms related to its initiation and clinical course. Keywords: paroxysmal atrial fi brillation, sinus rhythm, superoxide dismutase, catalase Folia Medica 2014; 56(2): 96-101Copyright © 2014 Medical University, Plovdiv РЕЗЮМЕ ВВЕДЕНИЕ: Механизмы, связанные с клиническим проявлением предсердного мерцания, вызывают значимый исследовательский интерес. ЦЕЛЬ: Изучить в динамике активность антиоксидантных энзимов супероксид дисмутаза и каталаз у пациентов с пароксизмальным предсердным мерцанием давностью < 48 ч. МАТЕРИАЛ И МЕТОДЫ: Показатели исследованы в эритроцитах 51 пациентов (59.84 ± 1.60, 26 муж-чин) непосредственно после их госпитализации -24-ый час и после восстановления синусового ритма -28-ой день. Обследовано и 52 здоровых человек в качестве контрольной группы (59.50 ± 1.46, 26 муж-чин) у которых не было данных о наличии аритмии. Регулирование ритма у всех пациентов добились использованием propafenone. Активность энзимов определена спектрометрически. РЕЗУЛЬТАТЫ: Сред-няя продолжительность предсердного мерцания до момента госпитализации в границах 8.14 ч. -от 2 до 24 ч. При госпитализации пациентов активность супероксид дисмутазы и каталаза оказ...

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The predictive value of inflammatory and oxidative markers following the successful cardioversion of persistent lone atrial fibrillation

Cited by 68 publications

References 40 publications

Role of Indoxyl Sulfate as a Predisposing Factor for Atrial Fibrillation in Renal Dysfunction

Role of Indoxyl Sulfate as a Predisposing Factor for Atrial Fibrillation in Renal Dysfunction

Circulating biomarkers of fibrosis and cardioversion of atrial fibrillation: A prospective, controlled cohort study

Paroxysmal Atrial Fibrillation: Dynamics of The Main Antioxidant Enzymes - Superoxide Dismutase and Catalase

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