have overlapping roles in the larval brain despite their distinct intracellular localizations. Dev. Biol. 250, 71-90. Alberici, P., de Pater, E., Cardoso, J., Bevelander, M., Molenaar, L., Jonkers, J. and Fodde, R. (2007). Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human. Am. J. Pathol. 170, 377-387. Andreu, P., Colnot, S., Godard, C., Gad, S., Chafey, P., Niwa-Kawakita, M., LaurentPuig, P., Kahn, A., Robine, S., Perret, C. et al. (2005). Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine.