The potential association between gingival crevicular fluid inflammatory mediators and adverse pregnancy outcomes: a systematic review

Stadelmann, Pascale; Alessandri, Regina; Eick, Sigrun; Salvi, Giovanni E.; Surbek, Daniel; Sculean, Anton

doi:10.1007/s00784-013-0952-0

Cited by 23 publications

(25 citation statements)

References 49 publications

(98 reference statements)

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“…Moreover, GCF levels of IL‐8, CRP, and IL‐1β were lower in cases compared to controls, which is discordant with the present findings. A systematic review on the relation between periodontal inflammation and adverse pregnancy outcomes concluded that there is an association between GCF inflammatory mediators and preterm birth 36 . However, because of great heterogeneity in the designs of reported studies, it was suggested that that association requires further confirmation and clarification through studies with a more systematic approach.…”

Section: Discussionmentioning

confidence: 99%

The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross‐Sectional Study

Perunović

Rakić

Nikolić³

et al. 2016

Journal of Periodontology

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Section: Discussionmentioning

confidence: 99%

The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross‐Sectional Study

Perunović

Rakić

Nikolić³

et al. 2016

Journal of Periodontology

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“…High levels of serum and amniotic fluid inflammatory mediators were associated with APO, especially PTB . A systematic review reported a positive association between APO and inflammatory mediator levels in gingival crevicular fluid, which is an inflammatory exudate from the gingival margin or within the gingival crevice . According to the above result, systemic inflammatory status caused by periodontal diseases might induce local inflammatory responses in the feto‐placental unit to increase the occurrence of APO.…”

Section: Inflammatory Mediators Produced By Gingival Submucosamentioning

confidence: 97%

Periodontal diseases and adverse pregnancy outcomes

Komine‐Aizawa

Aizawa

Hayakawa

2018

J of Obstet and Gynaecol

108

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From last decade of the 20th century, numerous epidemiological studies and intervention trials have attempted to prove the relationships between maternal periodontal diseases and adverse pregnancy outcomes (APO). Periodontal diseases are considered a risk factor for APO, including preterm birth, fetal growth restriction, low birthweight, pre-eclampsia and gestational diabetes. However, the efficacy of periodontal treatment during pregnancy is controversial. Two pathogenic mechanisms might explain the potential effect of periodontal diseases on pregnancy outcomes. First, periodontal bacteria originating in the gingival biofilm directly affect the feto-placental unit subsequent to bacteremia. Second, inflammatory mediators secreted by the subgingival inflammatory site are carried to the feto-placental unit, where they then cause an inflammatory response. To elucidate these mechanisms, many researchers have been investigating the use of experimental animal models and in vitro models. In the present review, we summarize the current literature on the relationship between periodontal diseases and APO from epidemiological studies, animal models studies and in vitro studies, and speculate on the possible mechanism of periodontal diseases affecting pregnancy outcomes.

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“…23 Although it has been asserted that periodontopathogens from oral infection can disseminate to distant body sites and thus result in the delivery of PLBW infants, results have been inconclusive. 24,25,26,27 Some studies have demonstrated positive correlations, while others have not. 28,29,30,31,32,33,34,35 Although these results seem contradictory, factors such as race, geographical location, and socioeconomic standards have not been adequately adjusted for.…”

Section: Discussionmentioning

confidence: 99%

Gingival Crevicular Fluid and Placental Tissue Levels of Interleukin-17 as a Possible Marker for Preterm Labor in Patients with Chronic Periodontitis

Gamal

Agoor

Shaker

et al. 2017

Perio J

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Background: The present study was conducted to evaluate the levels of interleukin (IL) -17 in gingival crevicular fluid (GCF) and placental tissue samples of pregnant females as a possible marker in determining whether or not an association exists between chronic periodontitis and preterm labor. Methods: This case-control study included a random sample of 40 female patients, aged 18 to 35 years, who were assigned to one of the following four groups (10 subjects each): group 1 included patients who underwent spontaneous preterm birth (PB) and were diagnosed with chronic periodontitis upon clinical examination (preterm/periodontitis); group 2 included patients who underwent spontaneous PB and who had a healthy periodontium upon clinical examination (preterm/healthy periodontium); group 3 included patients who underwent spontaneous normal term birth and were diagnosed with chronic periodontitis upon clinical examination (term/periodontitis); and group 4 included patients who underwent spontaneous normal term birth and who had a healthy periodontium upon clinical examination (term/healthy periodontium). GCF and placental tissue samples were obtained from each patient and IL-17 levels were measured using enzyme-linked immunosorbent assay (ELISA). Results: GCF levels of IL-17 were significantly higher (P=0.010) in patients with chronic periodontitis compared to those with a healthy periodontium. No significant differences were observed in IL-17 levels in placental tissue samples of all study groups. Conclusion: An association between chronic periodontitis and preterm labor could not be established based on IL-17 levels measured in the present study.

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The potential association between gingival crevicular fluid inflammatory mediators and adverse pregnancy outcomes: a systematic review

Abstract: The present findings suggest that an association between GCF inflammatory mediator levels and APO might exist.

Cited by 23 publications

References 49 publications

The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross‐Sectional Study

The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross‐Sectional Study

Periodontal diseases and adverse pregnancy outcomes

Gingival Crevicular Fluid and Placental Tissue Levels of Interleukin-17 as a Possible Marker for Preterm Labor in Patients with Chronic Periodontitis

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