The possible role of the seaweed Ulva fasciata on ameliorating hyperthyroidism-associated heart inflammations in a rat model

Ibrahim, Rasha Youssef Mohammed; Saber, Abdullah A.; Hammad, Huda Badr Ibrahim

doi:10.1007/s11356-020-11036-z

Cited by 14 publications

(12 citation statements)

References 65 publications

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“…These We also have demonstrated the effect of ClPs on limb withdrawal threshold (gram force) in CIA rats using PAM apparatus, which detects the mechanical hypersensitivity of chronic inflammatory joint pain (Barton et al, 2007). Histopathological investigation of the knee joint limetta peels against CIA rats could be due to the protective potential of hesperidin by diminishing the elevated level of inflammation, oxidative stress, and apoptosis markers as demonstrated in recent published reports (Afzal et al, 2020;Guazelli et al, 2020;Ibrahim, Saber, & Hammad, 2021). The maximum mitigation potential of ClPs was observed at 300 mg/kg body weight oral dose by considering the pharmacological, biochemical, and histology related parameters of arthritis; therefore, the human equivalent dose is 48.39 mg/kg body weight based on body surface area to convert animal dose in mg/kg to human equivalent dose in mg/kg (Nair & Jacob, 2016).…”

Section: Discussionmentioning

confidence: 64%

Hesperidin‐rich ethanol extract from waste peels of Citrus limetta mitigates rheumatoid arthritis and related complications

Babu

Binwal

Ranjana

et al. 2021

Phytotherapy Research

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The aim of this study is to explore the possible pharmacological effects of fruit waste that may have a key role in converting the fruit waste into pharmaceutical agents. Citrus limetta (Rutaceae) is an important commercial citrus fruit crops used by juice processing industries. C. limetta peels are perishable waste material, which creates a big challenge in juice processing industries. Initial pharmaco‐chemical profile of peels' extracts revealed that the ethanol extract (ClPs) has promising anti‐inflammatory activity and rich in hesperidin content. In vivo experimental pharmacology profile of ClPs against arthritis and related complications revealed that oral administration of ClPs significantly reduced the arthritis score and arthritis index in elbow and knee joints against collagen‐induced arthritis (CIA) in rats. Biochemical parameters include pro‐inflammatory cytokines (TNF‐α, IL‐6, and IL‐17A), and C‐RP level in blood serum of CIA rats further confirmed the anti‐arthritic profile of ClPs. Further individual experiments related to arthritis‐related complications in experimental animals demonstrated the analgesic, anti‐inflammatory, and antipyretic potential of ClPs in dose‐dependent manner. The result of this study suggests the suitability of ClPs as a drug‐like candidate for further investigation toward the management of arthritis and related complications.

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Section: Discussionmentioning

confidence: 64%

Hesperidin‐rich ethanol extract from waste peels of Citrus limetta mitigates rheumatoid arthritis and related complications

Babu

Binwal

Ranjana

et al. 2021

Phytotherapy Research

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“…Caffeic acid is among the hydroxycinnamic acids that have been found in U. lactuca extract obtained using water as a solvent [46]. Catechin is a wellknown flavonoid abundant in brown algae [47], and also present in methanolic extracts of macroalgae U. fasciata and U. lactuca [46,48] according to the literature. Rutin is another flavonoid whose presence in U. lactuca extracts obtained from different methanolic solvent systems has been reported [47].…”

Section: Phenolics Profilementioning

confidence: 99%

Extraction of Bioactive Compounds from Ulva lactuca

et al. 2022

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Macroalgae Ulva lactuca, has been employed as a natural source for the production of extracts with potent bioactivity. The biochemical characterization showed that the macroalgae biomass contains a remarkable amount of the polysaccharide Ulvan (49.9 wt%) which is a valuable chemical compound well known for its benefits in human health. Four nontoxic solvents, water, ethyl acetate, ethanol, and an ethanol/water mixture (70:30 v/v) were examined for their recovery efficiency of total carotenoid and phenolic contents. Experimental results showed that the aqueous mixture of ethanol was the most efficient solvent in the recovery of bioactive compounds with extraction yield of 10–15% dw. The effect of extraction parameters, namely time, temperature, and the ratio of biomass to solvent, on the carotenoid and phenolic compounds’ content, antioxidant activity, and extraction yield, was investigated, using the ethanol/water mixture as a solvent. The extract obtained under 60 °C, 3 h of extraction time and 1:10 biomass to solvent mass ratio showed the highest antioxidant activity. This extract maintained its antioxidant capacity almost stable for five days of storage under cool and dark conditions. Finally, specific phenolic and carotenoid compounds in the U. lactuca extracts were identified using the High-Performance Liquid Chromatography (HPLC) technique.

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“…Flavonols have numerous cardioprotective properties, such as platelet stabilization, anti-inflammatory, antidiabetic, antihypertensive, and hypocholesterolemic activity [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ]. To the best of our knowledge, quercetin is the most widely distributed and well-known flavonol obtained from natural sources, as well as the best-studied flavonol, in both in vitro and in vivo studies [ 51 ].…”

Section: Flavonols and Their Cardioprotective Activitymentioning

confidence: 99%

Targeting Cardiovascular Diseases by Flavonols: An Update

Kozłowska

Szostak-Węgierek

2022

Nutrients

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Flavonols are one of the most plentiful flavonoid subclasses found in natural products and are extensively used as dietary supplements. Numerous in vitro and in vivo studies have shown the cardioprotective properties of flavonols, especially quercetin. This group of substances exerts positive impacts primarily due to their antiatherogenic, antithrombotic, and antioxidant activities. The potential of flavonols to promote vasodilation and regulation of apoptotic processes in the endothelium are other beneficial effects on the cardiovascular system. Despite promising experimental findings, randomized controlled trials and meta-analyses have yielded inconsistent results on the influence of these substances on human cardiovascular parameters. Thus, this review aims to summarize the most recent clinical data on the intake of these substances and their effects on the cardiovascular system. The present study will help clinicians and other healthcare workers understand the value of flavonol supplementation in both subjects at risk for cardiovascular disease and patients with cardiovascular diseases.

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The possible role of the seaweed Ulva fasciata on ameliorating hyperthyroidism-associated heart inflammations in a rat model

Cited by 14 publications

References 65 publications

Hesperidin‐rich ethanol extract from waste peels of Citrus limetta mitigates rheumatoid arthritis and related complications

Hesperidin‐rich ethanol extract from waste peels of Citrus limetta mitigates rheumatoid arthritis and related complications

Extraction of Bioactive Compounds from Ulva lactuca

Targeting Cardiovascular Diseases by Flavonols: An Update

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