Hesperidin‐rich ethanol extract from waste peels of <i>Citrus limetta</i> mitigates rheumatoid arthritis and related complications

Babu, Vineet; Binwal, Monika; Ranjana, .; Kumari, Renu; Sen, Sumati; Kumar, Akhilesh; Mugale, Madhav Nilakanth; Shanker, Karuna; Kumar, Narendra; Bawankule, Dnyaneshwar Umrao

doi:10.1002/ptr.7053

Cited by 13 publications

(5 citation statements)

References 29 publications

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“…Tis was evident in its inhibitory efects on cartilage and bone degradation, decreased synovial space, increased infammatory cell infltration, and proinfammatory cytokines as well as mediators implicated in knee joint arthritis. Hence, bone remodeling could be upregulated to maintain bone integrity, and therefore, this agrees with earlier literature that reported the established ability of plant extracts to maintain the histopathological architecture of the bone and cartilage during arthritic infammation [35].…”

Section: Discussionsupporting

confidence: 91%

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Modulating Effects of the Hydroethanolic Leaf Extract of Persicaria lanigera R. Br. Soják (Polygonaceae) against Acute Inflammation

Antwi-Adjei

Obese

Adakudugu

et al. 2023

The Scientific World Journal

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Plant species have been used traditionally to treat numerous inflammatory disorders because of their known medicinal properties. This study aimed to assess the anti-inflammatory effect of aqueous ethanolic leaf extract of Persicaria lanigera using acute inflammatory models. The safety profile of the Persicaria lanigera extract was assessed using an acute toxicity model. The anti-inflammatory effect of the Persicaria lanigera leaf extract (100–600 mg·kg−1, p.o.) was studied in carrageenan-induced paw oedema, zymosan-induced knee joint arthritis, and histamine-induced paw oedema in Sprague–Dawley rats (n = 5). It was observed that the Persicaria lanigera leaf extract administered prophylactically significantly inhibited paw oedema from 99.01 ± 12.59 to 59.10 ± 4.94%, 56.08 ± 3.65%, and 48.62 ± 3.27% at 100 mg·kg−1, 300 mg·kg−1, and 600 mg·kg−1, while the standard drug, aspirin, showed 41.84 ± 9.25% in carrageenan-induced paw oedema, respectively. Furthermore, the extract decreased knee joint inflammation significantly from 62.43 ± 5.73% to 32.07 ± 2.98% and 24.33 ± 8.58% at 300 mg·kg−1 and 600 mg·kg−1 in zymosan-induced knee joint inflammation, respectively. In the histamine-induced paw oedema model, the extract significantly inhibited oedema to 61.53 ± 9.17%, 54.21 ± 9.38%, and 54.22 ± 9.37% at the same doses. Aqueous ethanolic leaf extract of Persicaria lanigera is safe and attenuates inflammation in acute inflammation models.

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Section: Discussionsupporting

confidence: 91%

“…According to Babu et al, histopathological changes in an arthritic knee joint are characterized by severe cell infiltration, loss of synovial space, cartilage and bone erosion, and distortion of the synovial membrane lining [ 35 ]. Hence, these pathological alterations are known to be clinical features of degenerative joint disorders.…”

Section: Discussionmentioning

confidence: 99%

Modulating Effects of the Hydroethanolic Leaf Extract of Persicaria lanigera R. Br. Soják (Polygonaceae) against Acute Inflammation

Antwi-Adjei

Obese

Adakudugu

et al. 2023

The Scientific World Journal

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“…We have also performed experiments to examine the effect of CLIV-92 on rheumatoid arthritis-induced complications i.e., inflammation, pain, and fever, using standard models as described [22]. CLIV-92 reduced carrageenan-induced acute inflammation in rats, indicating that CLIV-92 shows anti-inflammatory activity that could be beneficial in the treatment of acute inflammation.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological and Toxicological Study of Coumarinolignoids from Cleome viscosa in Small Animals for the Management of Rheumatoid Arthritis

et al. 2022

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This study aims to explore the possible pharmacological potential of Cleome viscosa Linn (Cleomaceae), an annual weed, into therapeutic value-added products. In the present study, we have explored the pharmacological and toxicological profile of coumarinolignoids isolated from Cleome viscose for the management of rheumatoid arthritis and related complications in a small animal model. To avoid the biasness during experiments on animals, we have coded the isolated coumarinolignoids as CLIV-92 to perform the experimental pharmacological study. CLIV-92 was orally administrated (30,100, 300 mg/kg) to animal models of collagen-induced arthritis (CIA), carrageenan-induced acute inflammation, thermal and chemical-induced pain, and Brewerʼs yeast-induced pyrexia. Oral administration of CLIV-92 significantly decreases the arthritis index, arthritis score, and increases the limb withdrawal threshold in the CIA model in experimental rats. The anti-arthritis studies revealed that the anti-inflammatory effect of CLIV-92 was associated with inhibition of the production of inflammatory mediators like TNF-α, IL-6, IL-17A, MMP-1, MMP-9, Nitric oxide, and C-RP in CIA ratʼs serum, and also reduced the NFкB-p65 expression as evidence of immunohistochemistry in knee joint tissue of CIA rats, in a dose-dependent manner. Further individual experiments related to arthritis-related complications in experimental animals demonstrated the analgesic, anti-inflammatory, and antipyretic potential of CLIV-92 in a dose-dependent manner. Further, an in-vivo acute oral toxicity study concluded that CLIV-92 is safe in experimental animals up to 2,000 mg/kg dose. The results of this study suggested that the oral administration of CLIV-92 may be a therapeutic candidate for further investigation in the management of rheumatoid arthritis and related complications.

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“…Among the forty MAPK8-targeting drugs retrieved, TANZISERTIB, CC-401, BENTAMAPIMOD, and HESPERADIN were shown to be inhibitors of MAPK8. As a predictive target of MAPK8, the drug HESPERADIN was shown to reduce arthritis scores, arthritis index, and inhibit serum levels of TNF-6, IL-17A, and CRP in CIA rats, and to exhibit analgesic, anti-inflammatory, and antipyretic potential in experimental animals 50 . A clearer understanding of the role MAPK8 plays in this process is still pending.…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics analysis of rheumatoid arthritis tissues identifies genes and potential drugs that are expressed specifically

Ding

2023

Sci Rep

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Studies have implicated necroptosis mechanisms in orthopaedic-related diseases, since necroptosis is a unique regulatory cell death pattern. However, the role of Necroptosis-related genes in rheumatoid arthritis (RA) has not been well described. We downloaded RA-related data information and Necroptosis-related genes from the Gene Expression Omnibus (GEO), Kyoto Gene and Genome Encyclopedia (KEGG) database, and Genome Enrichment Analysis (GSEA), respectively. We identified 113 genes associated with RA-related necroptosis, which was closely associated with the cytokine-mediated signaling pathway, necroptosis and programmed necrosis. Subsequently, FAS, MAPK8 and TNFSF10 were identified as key genes among 48 Necroptosis-associated differential genes by three machine learning algorithms (LASSO, RF and SVM-RFE), and the key genes had good diagnostic power in distinguishing RA patients from healthy controls. According to functional enrichment analysis, these genes may regulate multiple pathways, such as B-cell receptor signaling, T-cell receptor signaling pathways, chemokine signaling pathways and cytokine-cytokine receptor interactions, and play corresponding roles in RA. Furthermore, we predicted 48 targeted drugs against key genes and 31 chemical structural formulae based on targeted drug prediction. Moreover, key genes were associated with complex regulatory relationships in the ceRNA network. According to CIBERSORT analysis, FAS, MAPK8 and TNFSF10 may be associated with changes in the immune microenvironment of RA patients. Our study developed a diagnostic validity and provided insight to the mechanisms of RA. Further studies will be required to test its diagnostic value for RA before it can be implemented in clinical practice.

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Hesperidin‐rich ethanol extract from waste peels of Citrus limetta mitigates rheumatoid arthritis and related complications

Cited by 13 publications

References 29 publications

Modulating Effects of the Hydroethanolic Leaf Extract of Persicaria lanigera R. Br. Soják (Polygonaceae) against Acute Inflammation

Modulating Effects of the Hydroethanolic Leaf Extract of Persicaria lanigera R. Br. Soják (Polygonaceae) against Acute Inflammation

Pharmacological and Toxicological Study of Coumarinolignoids from Cleome viscosa in Small Animals for the Management of Rheumatoid Arthritis

Bioinformatics analysis of rheumatoid arthritis tissues identifies genes and potential drugs that are expressed specifically

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