The Physiology of Liver Enlargement

Wilson, Robert H.; Doell, B. H.; Gröger, W.; Hope, James; Gellatly, J.B.M.

doi:10.1016/b978-0-12-592550-1.50021-0

Cited by 18 publications

(8 citation statements)

References 86 publications

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“…Acid phosphatase is a lysosomal enzyme and is stimulated in cases of tissue damage. [ 18 ] Increase in level of acid phosphatase in liver and kidney might be suggestive of increasing physiological phagocytosis[ 19 ] and the moderate amount of acid phosphatase activity in regressing luteal cells of the ovary indicated lysosomal activity in luteolysis. [ 20 ] The increase in acid phosphatase activity estimated biochemically would, therefore, mean a destruction of the luteal cells, which is in support of the fact that absence of acetylecholinesterase activity in ovary also causes lack of steroidogenesis.…”

Section: Resultsmentioning

confidence: 99%

Toxicological approach in chronic exposure to lead on reproductive functions in female rats(Rattus norvegicus)

Dhir

Dhand

2010

Toxicol Int

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Lead being a toxic cumulative poison and an environmental pollutant, experiments were conducted at an oral chronic dose of (60 mg/kg/day) for 90 days on adult female rats (Rattus Norvegicus) and its effect on the reproductive functions in relation to the biochemical effects was studied. It was observed that the chronic dose of lead caused an elevation in the level of proteins, acid phosphatase, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase in all the soft tissues studied indicating tissue damage. It also inhibited the level of acetylcholinesterase in all the tissues. Fertility tests by pairing treated females with males showed that lead-treated female showed irregular estrous cycle and the fertility rate dropped to 40% as female pups of lead-treated mothers showed loss in weight, high mortality rate, poor growth rate, and late vaginal opening. Histological studies of ovary showed atresia in all the stages of folliculogenesis sustaining the poor fertility observations. The present study revealed that lead caused great tissue damage and affected reproductive performance of female rats at a chronic dose.

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Section: Resultsmentioning

confidence: 99%

Toxicological approach in chronic exposure to lead on reproductive functions in female rats(Rattus norvegicus)

Dhir

Dhand

2010

Toxicol Int

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“…L'étude des modifications histopathologiques, souvent envisagée dans le cas des huiles chauffées, ne permet de déceler qu'un stade tardif de l'effet toxique (Golberg, 1967). Finalement, un des tests les plus intéressants pour juger la signification d'une hypertrophie hépatique est celui qui a été proposé par Wilson et al (1970) : il consiste à chercher s'il y a réversibilité du phénomène observé, lorsque l'on cesse l'administration du composé responsable de l'hypertrophie hépatique. D'après Hart et Fouts (1965), la réversibilité est décelable en quelques jours, mais le retour complet à la normale peut nécessiter plusieurs semaines, dépendant en cela de la persistance du composé responsable dans les tissus.…”

Section: Matériel Et Méthodesunclassified

Détoxification par le rat des composés formés au cours de la thermopolymérisation de l'huile de lin. II. — Effets d'une administration discontinue d'huile chauffée sur l'excrétion urinaire de glucuronides, le poids du foie et les teneurs tissulaires en monomères cycliques

Zarambaud¹,

Grandgirard²,

Julliard³

1981

Reprod. Nutr. Dévelop.

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During four successive periods of 9 days each, adult rats were fed alternatively fresh or hermopolymerized linseed oil in their diet.As compared to the control animals, the rats fed with the thermopolymerized oil showed increased urinary glucuronide excretion and higher liver weight, as well as a rise in the cyclic monomer content in that organ and, to a lesser degree, in the fat tissue.When fresh oil was substituted for heated oil in the diet, these animals recovered the levels of urinary glucuronides and liver monomers observed in the control rats. On the contrary, the rise in liver weight still observed can be considered as an indication of diet toxicity.Introduction.

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“…In the 1960s, the programme was extended to include 2 yr rat and 80 wk mouse feeding studies, a 90-day feeding study in a nonrodent (chicken), studies of PGPR-induced liver and kidney enlargement in rats, mice and chickens, metabolism in the rat using radiolabelled materials, and human studies on the digestibility and absorption of PGPR which included liver and kidney function tests. e results of these studies have been published in several papers [40,[48][49][50][51][52]. PGPR was found to be 98% digested by rats and utilized as a source of energy superior to starch and nearly equivalent to groundnut oil.…”

Section: Polyglycerol Polyricinoleatementioning

confidence: 99%

The Food Additive Polyglycerol Polyricinoleate (E-476): Structure, Applications, and Production Methods

Bastida

2013

ISRN Chemical Engineering

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e food additive named polyglycerol polyricinoleate (PGPR) and identi�ed with the code E-476 (PGPR) is used as emulsi�er in tin-greasing emulsions for the baking trade and for the production of low-fat spreads. However, the main application of PGPR is in the chocolate industry, where, besides its action as an emulsi�er, it also has important properties as a viscosity modi�er and thus improves the moulding properties of the molten chocolate. An additional property of PGPR in chocolate is its ability to limit fat bloom. �nown chemical methods for preparing this emulsi�er involve long reaction times and high operating temperatures, which adversely affect the quality of the �nal product leading to problems of coloration and odors that could make it inadvisable for the food industry. As an alternative, the enzymatic synthesis of PGPR by the catalytic action of two lipases has been developed. e enzymes act in mild reaction conditions of temperature and pressure, neutral pH, and in a solvent-free system, which makes the process environmentally friendly and avoids side reaction, so that the product has a higher purity and quality.

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The Physiology of Liver Enlargement

Cited by 18 publications

References 86 publications

Toxicological approach in chronic exposure to lead on reproductive functions in female rats(Rattus norvegicus)

Toxicological approach in chronic exposure to lead on reproductive functions in female rats(Rattus norvegicus)

Détoxification par le rat des composés formés au cours de la thermopolymérisation de l'huile de lin. II. — Effets d'une administration discontinue d'huile chauffée sur l'excrétion urinaire de glucuronides, le poids du foie et les teneurs tissulaires en monomères cycliques

The Food Additive Polyglycerol Polyricinoleate (E-476): Structure, Applications, and Production Methods

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