Toxicological approach in chronic exposure to lead on reproductive functions in female rats<i>(Rattus norvegicus)</i>

Dhir, Vaneet; Dhand, P

doi:10.4103/0971-6580.68340

Cited by 17 publications

(12 citation statements)

References 22 publications

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“…This strongly suggests that high levels of lead are linked to altered reproductive function (Piasek and Kostial, 1991;Taupeau et al, 2001;Silberstein et al, 2006). Dhir and Dhand (2010) reported that ovarian atresia was present in female rats following chronic exposure to lead, a finding also confirmed by other authors (Taupeau et al, 2001;Qureshi et al, 2010;Sharma et al, 2012). In a previous study we ascertained that when lead acetate was administered for a long period of time (12 months) to female rats, important changes in the rat serum panel took place.…”

Section: Discussionsupporting

confidence: 77%

Effects of long-term exposure of female rats to low levels of lead: ovary and uterus histological architecture changes

Dumitrescu¹,

Chiurciu²,

Муселин³

et al. 2015

Turk J Biol

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The aim of the current study was to evaluate lead accumulation in the ovaries, fallopian tubes, and uterus and to take note of any consequent histo-architectural changes. The experiment involved a 12-month chronic exposure of 28 Wistar female rats at sexual maturity (221 ± 0.88 g/individual) to lead acetate in drinking water. The rats were divided into 4 groups based on the level of lead exposure: E1 at 0.050 mg L -1 , E2 at 0.100 mg L -1 , E3 at 0.150 mg L -1 , and a control group that received tap water. Lead level evaluation was performed by atomic absorption spectrometry at 283.3 nm and the histo-architectonics in target organs were evaluated after hematoxylin and eosin staining and microscopy. The exposure to lead acetate produced significant histological alterations caused by lead accumulation in the sexual organs. These structural changes correlated with the level of exposure in the ovaries, uterus, and fallopian tubes. They were mainly edemas and necrosis, denudation, and/or different stages of follicle evolution. These alterations have been shown to indicate infertility in female rats.

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Section: Discussionsupporting

confidence: 77%

Effects of long-term exposure of female rats to low levels of lead: ovary and uterus histological architecture changes

Dumitrescu¹,

Chiurciu²,

Муселин³

et al. 2015

Turk J Biol

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“…Histopathological examination of the ovarian tissues showed diffused atretic and degenerative changes of growing and mature follicles. Lead exposure caused atresia in all stages of follicle formation which is in support of the previous finding by [30]. These investigations clearly emphasize that lead exposure is extremely dangerous for ovarian and oviduct tissue which may lead to reproductive disorders, Several lead containing compounds can cause enzyme dysfunction, which probably accounts for their mechanisms of toxicity on the reproductive system, which might have resulted in terms of shrinkage of lumen and apoptic damages might have resulted due to increase in free radical load.…”

Section: Discussionsupporting

confidence: 87%

Impairment of Ovarian and Uterine Cellular Architecture, Total Protein Content: A Consequence of Lead Nitrate Induced Increased Free Radical Load

Rai¹

2015

ABB

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A significant decrease in weight of ovary and oviduct of female rats was noted following lead nitrate administration with a dose 80 mg/kg body weight/day for 28 days. Histomicrogaphs of ovary showed marked inhibition of follicular growth as judged by gradual decrease oocyte size, absence of theca and granulosa layer, resulting absence of graafian follicle. Oviduct showed shrinkage in lumen and damage in perimetrium cells. Increase in total protein of ovary and oviduct after lead nitrate treatment denoting changes at translational level of concern gene to prevent the normal physiology. A significant increase in the thiobarbituric acid reactive substances (TBARS) of both tissues denotes increased free radical load resulted in the damage of cellular architecture. Findings, suggest that lead entering to the biological system via environment and other widely used industrial product may interfere with the normal reproductive physiology and folliculogenesis could be one of the cause of female infertility.

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“…In general, the authors also reported that the morphology of the ovary was affected after exposure to lead acetate. Thus, lead clearly interferes with the development of growing follicles [ 94 ].…”

Section: Lead (Pb)mentioning

confidence: 99%

Effects of Cadmium, Lead, and Mercury on the Structure and Function of Reproductive Organs

Massányi

Madeddu

et al. 2020

Toxics

137

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Reproductive organs are essential not only for the life of an individual but also for the survival and development of the species. The response of reproductive organs to toxic substances differs from that of other target organs, and they may serve as an ideal “barometer” for the deleterious effects of environmental pollution on animal and human health. The incidence of infertility, cancers, and associated maladies has increased in the last fifty years or more, while various anthropogenic activities have released into the environment numerous toxic substances, including cadmium, lead, and mercury. Data from epidemiological studies suggested that environmental exposure to cadmium, lead, and mercury may have produced reproductive and developmental toxicity. The present review focused on experimental studies using rats, mice, avian, and rabbits to demonstrate unambiguously effects of cadmium, lead, or mercury on the structure and function of reproductive organs. In addition, relevant human studies are discussed. The experimental studies reviewed have indicated that the testis and ovary are particularly sensitive to cadmium, lead, and mercury because these organs are distinguished by an intense cellular activity, where vital processes of spermatogenesis, oogenesis, and folliculogenesis occur. In ovaries, manifestation of toxicity induced by cadmium, lead, or mercury included decreased follicular growth, occurrence of follicular atresia, degeneration of the corpus luteum, and alterations in cycle. In testes, toxic effects following exposure to cadmium, lead, or mercury included alterations of seminiferous tubules, testicular stroma, and decrease of spermatozoa count, motility and viability, and aberrant spermatozoa morphology.

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Toxicological approach in chronic exposure to lead on reproductive functions in female rats(Rattus norvegicus)

Cited by 17 publications

References 22 publications

Effects of long-term exposure of female rats to low levels of lead: ovary and uterus histological architecture changes

Effects of long-term exposure of female rats to low levels of lead: ovary and uterus histological architecture changes

Impairment of Ovarian and Uterine Cellular Architecture, Total Protein Content: A Consequence of Lead Nitrate Induced Increased Free Radical Load

Effects of Cadmium, Lead, and Mercury on the Structure and Function of Reproductive Organs

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