Détoxification par le rat des composés formés au cours de la thermopolymérisation de l'huile de lin. II. — Effets d'une administration discontinue d'huile chauffée sur l'excrétion urinaire de glucuronides, le poids du foie et les teneurs tissulaires en monomères cycliques

Zarambaud, A. Damy; Grandgirard, A.; Julliard, F.

doi:10.1051/rnd:19810307

Cited by 5 publications

(3 citation statements)

References 3 publications

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“…Nevertheless, some differences may be underlined. We may suggest that the radioactivity was present in hydrophilic compounds produced by the detoxification of CFAM via the drugmetabolising pathway as previously suggested by Iwaoka and Perkins [12] and Damy Zarambaud and Grandgirard [13]. In our experimental conditions of partial fasting, two different prominent metabolic pathways may be suggested for the fatty acids: oxidation and elimination by detoxification without prior β-oxidation.…”

Section: Discussionsupporting

confidence: 52%

In vivo oxidation of carboxyl-labelled cyclic fatty acids formed from linoleic and linolenic acids in the rat

et al. 2004

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-Cyclic fatty acid monomers (CFAM), which occur from the intramolecular cyclisation of linoleic and linolenic acids, are subsequently present in some edible oils and are suspected to induce metabolic disorders. One may suggest that the presence of a ring would alter the ability of the organism to oxidise these molecules. In order to test this hypothesis, we assessed the oxidative metabolism of CFAM in rats. For this purpose, rats were force-fed from 1.5 to 2.6 MBq of [1-14 C]-linoleic acid, [1-14 C]-linolenic acid, [1-14 C]-CFAM-18:2 or [1-14 C]-CFAM-18:3, and 14 CO 2 production was monitored for 24h. The animals were then sacrificed and the radioactivity was determined in different tissues. No significant differences in 14 CO 2 production were found 24h after the administration of CFAM and their respective precursors. Our data clearly demonstrate that, at least for the first β-oxidation cycle, CFAM are oxidised in a similar way as both essential fatty acids.heating oil / essential fatty acids / oxidation / metabolism

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Section: Discussionsupporting

confidence: 52%

In vivo oxidation of carboxyl-labelled cyclic fatty acids formed from linoleic and linolenic acids in the rat

et al. 2004

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“…At the end of the experiment, the weight of the animals fed with heated oil was significantly lower (7 %) and their liver and kidneys were heavier (respectively 35 and 24 %) than the control animals, as has already been described in previous studies [3,17,18]. However, our results do not confirm this assumption.…”

Section: Resultscontrasting

confidence: 57%

Trans isomers of long-chain n-3 polyunsaturated fatty acids in tissue lipid classes of rats fed with heated linseed oil

Grandgirard

Piconneaux²,

Sébédio³

et al. 1998

Reprod. Nutr. Dev.

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-The isomerization of linolenic acid into mono-and di-trans isomers takes place during heat treatment. One of these compounds, l8:3ð.9c, l2c, 15t can be desaturated and elongated to form, in particular, the trans isomers of eicosapentaenoic and docosahexaenoic acids. This study was undertaken to observe the incorporation of these trans long-chain n-3 polyunsaturated fatty acids into the lipid classes of several tissues. Rats were fed for 8 weeks with heated linseed oil containing high levels of trans linolenic acid isomers. The lipid classes of the liver, kidney, heart and adrenals of these rats contained various levels of these compounds. The 20:5A5c,8c,1 c,14c,17t represented between 80 and 90 % of the total 20:5 in the phospholipids, but 22:5A7c, I Oc.l3c.l6c, 19t and mainly 22:6ð.4c,7c,lOc,13c,16c,19t

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“…Enhanced excretion of urinary and fecal glucuronides has previously been reported in animals fed either linolenic acid-derived cyclic fatty acid fractions [16] (Grandgirard, unpublished data) or cyclic fatty acid enriched-thermopolymerized linseed oil [17]. Although we did not elucidate the nature of the radioactivity in the gastrointestinal tract and stools, we assume that this value corresponded to glucurono-conjugates of chain shortened cyclic fatty acids.…”

Section: Resultsmentioning

confidence: 69%

In vivo oxidation of [9-14C] cyclic fatty acids derived from linolenic acid in the rat

et al. 2006

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-Heating oils and fats may lead to cyclization of polyunsaturated fatty acids, as for example linolenic acid. Cyclohexenyl and cyclopentenyl fatty acids are subsequently present in some edible oils and these are suspected to induce metabolic disorders. In a previous experiment using [1-14 C] labeled molecules, we published that these cyclic fatty acids are beta oxidized to the same extent as linolenic acid, at least for the first cycle of beta oxidation. However, it is possible that the presence of a ring could alter the ability of the organism to fully oxidize the molecule. In order to test this hypothesis, we assessed the oxidative metabolism of cyclic fatty acids carrying a 14 C atom at the vicinity of the ring. For this purpose, rats were force-fed from 1.1 to 1.3 MBq of a representative fraction of dietary cyclohexenyl cyclic fatty acid monomers of [9-14 C] 9-(6-propyl-cyclohex-3-enyl)-non-8-enoic acids and 14 CO 2 production was monitored for 24h. The animals were then necropsied and the radioactivity was determined in different tissues. No consistent radioactivity was recovered as 14 CO 2 24h after administration of the molecules. Sixty percent of the radioactivity was recovered in the urine and 30% in the gastrointestinal tract. By combining our previous data on the oxidation of [1-14 C] cyclic fatty acids and the present results, we suggest that cyclohexenyl fatty acids are first beta oxidized in a similar way as linolenic acid and that the remaining molecule carrying the ring is detoxified and eliminated in the urine and feces. cyclic fatty acid monomers / linolenic acid / oxidation

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Détoxification par le rat des composés formés au cours de la thermopolymérisation de l'huile de lin. II. — Effets d'une administration discontinue d'huile chauffée sur l'excrétion urinaire de glucuronides, le poids du foie et les teneurs tissulaires en monomères cycliques

Cited by 5 publications

References 3 publications

In vivo oxidation of carboxyl-labelled cyclic fatty acids formed from linoleic and linolenic acids in the rat

In vivo oxidation of carboxyl-labelled cyclic fatty acids formed from linoleic and linolenic acids in the rat

Trans isomers of long-chain n-3 polyunsaturated fatty acids in tissue lipid classes of rats fed with heated linseed oil

In vivo oxidation of [9-14C] cyclic fatty acids derived from linolenic acid in the rat

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