The permeability of mammalian nonkeratinized oral epithelia to horseradish peroxidase applied in vivo and in vitro

Squier, C. A.; Hall, B.K.

doi:10.1016/0003-9969(84)90041-4

Cited by 41 publications

(17 citation statements)

References 11 publications

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“…In both keratinized and non-keratinized epithelia, the limit of penetration coincided with the level where the MCGs could be seen adjacent to the superficial plasma membranes of the epithelial cells. Since the Available online on www.ijpsr.com 15 same result was obtained in both keratinized and non-keratinized epithelia, keratinization by itself is not expected to play a significant role in the barrier function 6 . The components of the MCGs in keratinized and non-keratinized epithelia are different, however 8 .…”

Section: Fig 1: Structure Of the Oral Mucosamentioning

confidence: 56%

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2011

IJPSR

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Buccal controlled drug delivery system has been developed since the environment of the oral cavity provides potential sites for drug delivery. The acid hydrolysis and first pass effects can be avoided. The release of drug can be affected by continuous secretion of saliva. The mucin film exists in oral mucosa offers an opportunity to develop mucoadhesive system, which retain at absorption site for prolonged time by mucoadhesive binding. The close contact with absorption membrane causes more absorption of the drug. The pH of buccal cavity ranges between 5-7, and does not cause any problem to the drug with the right dosage form design and formulation; the permeability and the local environment of the mucosa can be controlled and manipulated in order to accommodate drug permeation. Buccal drug delivery is a promising area for continued research with the aim of systemic delivery of orally inefficient drugs as well as a feasible and attractive alternative for non-invasive delivery of potent peptide and protein drug molecules. The objective of this article is to review mucosa as a route for drug delivery by discussing the structure, environment, permeability, dynamics etc. of the buccal mucosa and the materials used for oral permeation enhancers.

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Section: Fig 1: Structure Of the Oral Mucosamentioning

confidence: 56%

Section: Fig 1: Structure Of the Oral Mucosamentioning

confidence: 99%

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2011

IJPSR

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“…This barrier exists in the outermost 200μm of the superficial layer. Permeation studies have been performed using a number of very large molecular weight tracers, such as horseradish peroxidase [28] and lanthanum nitrate. [29] When applied to the outer surface of the epithelium, these tracers penetrate only through outermost layer or two of cells.…”

Section: World Journal Of Pharmacy and Pharmaceutical Sciencesmentioning

confidence: 99%

“…Since the same result was obtained in both keratinizedand non-keratinized epithelia, keratinization by itself is not expected to play a significant role in the barrier function. [28] The components of the MCGs in keratinized and non-keratinized epithelia are different, however. [23] The MCGs of keratinized epithelium are composed of lamellar lipid stacks, whereas the non-keratinized epithelium contains MCGs that are nonlamellar.…”

Section: World Journal Of Pharmacy and Pharmaceutical Sciencesmentioning

confidence: 99%

Buccoadhesive Drug Delivery System- A Review

Sourav¹

2017

WJPPS

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“…Drug permeability appears to be highest in the sublingual area and lowest at the gingival site [14]. It is recently believed that the permeability barrier in the oral mucosa is a result of intercellular material derived from the so-called membrane coating granules (MCG) [15,16]. This barrier exists in the outermost 200 µm of the superficial layer.…”

Section: Permeabilitymentioning

confidence: 99%

A Smart Oro-Soft Palate Mucosal Drug Delivery: Credentials and Future Trends

Shankar

Madhav

2015

Marmara Pharm J

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Over the last few decades pharmaceutical scientists throughout the world are trying to explore transdermal and transmucosal routes as an alternative to injections. The main impediment for the oral delivery of the drugs as potential therapeutic agents is their extensive pre-systemic metabolism, instability in acidic environment associated with inadequate and erratic oral absorption. The parenteral route is the only established route that overcomes all the drawbacks related with the orally inefficient drugs. However the parenteral formulations are expensive, need frequent administration, with less patient compliance and other harmful effects. Since ancient times oral transmucosal drug delivery has received intensive interest for the systemic delivery of drugs proved to have better systemic bioavailability achieved by oromucosal route. Oral mucosal drug delivery provides an alternative method of systemic drug delivery which offers many advantages for both parenterals and oral methods. The oral mucosa is highly vascularised, hence drugs which are absorbed through the oral mucosa directly enter into the systemic circulation, bypassing the enzymes present in the gastrointestinal tract and first-pass metabolism in the liver. The various transmucosal sites available are sublingual and buccal, but also the soft-palatal mucosa was found to be the most convenient and easily accessible novel site for the delivery of therapeutic agents for systemic delivery as retentive dosage forms. It has adequate blood supply, rapid cellular recovery time after exposure to stress, flexible, smooth surface, devoid of mechanical irritation, local discomfort and non-invasive route. Recently soft palate route explore more attention towards the scientist as an alternative to buccal route for administering drugs using mucoadhesive drug delivery dosage forms. This review focuses the more recent advances in novel soft palate route and formulation strategies to design dosage forms to administer drug through this novel soft palate route.

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The permeability of mammalian nonkeratinized oral epithelia to horseradish peroxidase applied in vivo and in vitro

Cited by 41 publications

References 11 publications

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Untitled

Buccoadhesive Drug Delivery System- A Review

A Smart Oro-Soft Palate Mucosal Drug Delivery: Credentials and Future Trends

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