Untitled

Abstract

Buccal controlled drug delivery system has been developed since the environment of the oral cavity provides potential sites for drug delivery. The acid hydrolysis and first pass effects can be avoided. The release of drug can be affected by continuous secretion of saliva. The mucin film exists in oral mucosa offers an opportunity to develop mucoadhesive system, which retain at absorption site for prolonged time by mucoadhesive binding. The close contact with absorption membrane causes more absorption of the drug. The pH of buccal cavity ranges between 5-7, and does not cause any problem to the drug with the right dosage form design and formulation; the permeability and the local environment of the mucosa can be controlled and manipulated in order to accommodate drug permeation. Buccal drug delivery is a promising area for continued research with the aim of systemic delivery of orally inefficient drugs as well as a feasible and attractive alternative for non-invasive delivery of potent peptide and protein drug molecules. The objective of this article is to review mucosa as a route for drug delivery by discussing the structure, environment, permeability, dynamics etc. of the buccal mucosa and the materials used for oral permeation enhancers.