A Smart Oro-Soft Palate Mucosal Drug Delivery: Credentials and Future Trends

Shankar, Uma; Madhav, Satheesh

doi:10.12991/mpj.20151930308

Cited by 4 publications

(2 citation statements)

References 77 publications

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“…It has become a favorable site for therapeutic application in the treatment of diseases of the oral cavity ( Verma et al, 2014 ). Oral transmucosal drug delivery is a systemic drug delivery approach that has various advantages over parenteral and oral delivery system ( Umashankar, 2015 ). A stratified squamous epithelium forms the outermost layer of the oral mucosa, which is followed by a basement membrane, a laminar propria, and lastly a submucosa as the innermost layer.…”

Section: Transmucosal Routes Of Vaccine Deliverymentioning

confidence: 99%

Nanocarriers-Assisted Needle-Free Vaccine Delivery Through Oral and Intranasal Transmucosal Routes: A Novel Therapeutic Conduit

et al. 2022

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Drug delivery using oral route is the most popular, convenient, safest and least expensive approach. It includes oral transmucosal delivery of bioactive compounds as the mucosal cavity offers an intriguing approach for systemic drug distribution. Owing to the dense vascular architecture and high blood flow, oral mucosal layers are easily permeable and can be an ideal site for drug administration. Recently, the transmucosal route is being investigated for other therapeutic candidates such as vaccines for their efficient delivery. Vaccines have the potential to trigger immune reactions and can act as both prophylactic and therapeutic conduit to a variety of diseases. Administration of vaccines using transmucosal route offers multiple advantages, the most important one being the needle-free (non-invasive) delivery. Development of needle-free devices are the most recent and pioneering breakthrough in the delivery of drugs and vaccines, enabling patients to avoid needles, reducing anxiety, pain and fear as well as improving compliance. Oral, nasal and aerosol vaccination is a novel immunization approach that utilizes a nanocarrier to administer the vaccine. Nanocarriers improve the bioavailability and serve as adjuvants to elicit a stronger immune response, resulting in increased effectiveness of vaccination. Drugs and vaccines with lower penetration abilities can also be delivered transmucosally while maintaining their biological function. The development of micro/nanocarriers for transmucosal delivery of macromolecules, vaccines and other substances is currently drawing much attention and a number of studies were performed recently. This comprehensive review is aimed to summarize the most recent investigations on needle-free and non-invasive approaches for the delivery of vaccines using oral transmucosal route, their strengths and associated challenges. The oral transmucosal vaccine delivery by nanocarriers is the most upcoming advancement in efficient vaccine delivery and this review would help further research and trials in this field.

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Section: Transmucosal Routes Of Vaccine Deliverymentioning

confidence: 99%

Nanocarriers-Assisted Needle-Free Vaccine Delivery Through Oral and Intranasal Transmucosal Routes: A Novel Therapeutic Conduit

et al. 2022

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“…It is innervated through CN V (i.e. lesser palatine nerve) (Shankar, Madhav, 2015;Shakya, Madhav, Shakya, 2011).…”

Section: Introductionmentioning

confidence: 99%

A smart approach for delivery of aripiprazole via oro-soft palatal mucosal route for improved therapeutic efficacy

Madhav

Ojha

Jaiswal

2018

Braz. J. Pharm. Sci.

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Effective management of schizophrenia, acute mania, mixed episodes associated with bipolar disorders, and depression can be managed with aripiprazole moiety. In the present research work an attempt was made to minimize the dose related side effects thus improving the quality life of the patients. A novel biopolymer was isolated from the fruits of Trachyspermum ammi. Ten optimized nanosized aripiprazole loaded formulations were prepared in 1-5% concentration of biopolymer (FA1-FA5) and sodium CMC (FM1-FM5) by solvent casting technique. The formulated flexy films were evaluated for thickness, folding endurance, weight uniformity, surface pH, mucoadhesivity, In-vitro drug release studies, In-vivo pharmacodynamic study and stability studies. The isolated biopolymer showed inbuilt fimability and mucoadhesivity and consists of carbonyl, hydroxyl and thiocarbonyl functional groups. All formulations showed folding endurance from 153 to 170, mucoadhesion time in the range of 24-48hrs., and in-vitro drug release was performed using dynamic Franz Diffusion cell and analyzed using BIT-SOFTWARE. The experimental animals showed improved activity score on actophotometer. The formulated nanosized aripiprazole loaded bio-flexy films showed pharmacotherapeutic response. Conclusion can be drawn that optimized formulation showed effective Pharmacodynamic activity and can be used as for improving therapeutic efficacy of aripiprazole through this platform.

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The dawning era of oral thin films for nutraceutical delivery: From laboratory to clinic

Ruchika,

Khan,

Dogra

et al. 2024

Biotechnology Advances

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A Smart Oro-Soft Palate Mucosal Drug Delivery: Credentials and Future Trends

Cited by 4 publications

References 77 publications

Nanocarriers-Assisted Needle-Free Vaccine Delivery Through Oral and Intranasal Transmucosal Routes: A Novel Therapeutic Conduit

Nanocarriers-Assisted Needle-Free Vaccine Delivery Through Oral and Intranasal Transmucosal Routes: A Novel Therapeutic Conduit

A smart approach for delivery of aripiprazole via oro-soft palatal mucosal route for improved therapeutic efficacy

The dawning era of oral thin films for nutraceutical delivery: From laboratory to clinic

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