The Opposite Effects of High-Sucrose and High-Fat Diet on Fatty Acid Oxidation and Very Low Density Lipoprotein Secretion in Rat Model of Metabolic Syndrome

Cahová, Monika; Daňková, Helena; Páleníčková, Eliška; Papáčková, Zuzana; Kazdová, Ludmila

doi:10.1155/2012/757205

Cited by 24 publications

(32 citation statements)

References 32 publications

(25 reference statements)

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“…These differences are probably due to the lowest amounts of fat and sucrose included simultaneously in present diet than all the prior individual studies. In addition, foodcalorie-body weight relation of present study is in accordance with other studies using rats under high calorie diets (Moura et al, 2012), with the significant increase of the sera glucose value in animal models under a diet with high saturated fat content (Cahova et al, 2012) and the registration of blood pressure was not done in the prior coconut or sucrose studies (Cera et al, 1990;Buettner et al, 2006;Buettner et al, 2007;Amin et al, 2011;Cahova et al, 2012).…”

Section: Discussionsupporting

confidence: 90%

“…On the other hand, the E data are contrary to the fast weight gain and on set of hyperphagia observed in prior coconut fat or sucrose studies (Buettner et al, 2006;Buettner et al, 2007;Amin et al, 2011;Cahova et al, 2012), increased values of creatinine and urea in serum due to a high sucrose diet (Amin et al, 2011) and unaltered sera values of glucose in previous coconut fat or sucrose evaluations ( (Cera et al, 1990;Buettner et al, 2006;Buettner et al, 2007;Amin et al, 2011;Cahova et al, 2012). These differences are probably due to the lowest amounts of fat and sucrose included simultaneously in present diet than all the prior individual studies.…”

Section: Discussioncontrasting

confidence: 57%

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Nutritional and biochemical effects of aspartame intake in rats under an experimental diet

Martinez-Morales¹,

Maldonado‐Cervantes²,

Isiordia-Espinoza³

et al. 2015

JEBAS

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The present study evaluates the effect of aspartame intake in rats under a diet mimicking the trends of fat consumption in the society. The composition of the experimental diet was within the recommended human limits except the saturated fat amount supplying from coconut fat. Rats under the experimental diet showed an increase in the body weight, transitory increase in the blood pressure and in plasma values of glucose and triglycerides alongside a transitory reduction in plasma urea versus the standard group. Rats under the experimental diet plus aspartame intake (54.8 ± 7.3 mg/kg bw/day) did not show any increase of body weight and in plasma values of glucose and triglycerides while showed an improvement in the plasma value of urea with respect the group under only the experimental diet. However, the aspartame group showed a more maintained increase of blood pressure. In conclusion, experimental diet produces negative effects on cardiovascular risk factors of the rats while the aspartame intake under the experimental feeding had mixed effects on the cardiometabolic factors of the animals.

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Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 57%

Nutritional and biochemical effects of aspartame intake in rats under an experimental diet

Martinez-Morales¹,

Maldonado‐Cervantes²,

Isiordia-Espinoza³

et al. 2015

JEBAS

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“…Long-term administration of a high-fat (HF) diet induces hepatic steatosis and, consequently, insulin resistance (IR) [Aguila et al, 2010] via pathways that reduce triacylglycerol (TAG) and very low-density lipoprotein secretion [Cahova et al, 2012]. Furthermore, saturated fat intake promotes an increase in gluconeogenesis and reduces glucose uptake by the liver, which leads to decreased glucose tolerance [Fatani et al, 2011].…”

Section: Introductionmentioning

confidence: 99%

“…The correlation between a high-sucrose (HSu) diet and liver steatosis depends on de novo lipogenesis and TAG secretion, a decrease in free fatty acid oxidation and enhanced very low-density lipoprotein output from the liver [Jorns et al, 2002;Roberts et al, 2008;Chen et al, 2011;Fatani et al, 2011;Cahova et al, 2012]. This mechanism promotes ectopic fat deposition in the liver [Snel et al, 2012], leading to a loss of control over glucose output and, consequently, hyperglycemia and compensatory hyperinsulinemia [Whiteman et al, 2002].…”

Section: Introductionmentioning

confidence: 99%

Short Exposure to a High-Sucrose Diet and the First ‘Hit' of Nonalcoholic Fatty Liver Disease in Mice

Fernandes-Lima¹,

Monte²,

Nascimento³

et al. 2016

Cells Tissues Organs

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High-sucrose and high-fat diets induce deregulation in the metabolism of lipids and carbohydrates. This study aimed to detect the initial consequences on lipogenesis, gluconeogenesis and insulin signaling in the livers of rodents fed high-fat and/or high-sucrose diets for a short period of time. Male mice received a standard chow (SC), high-fat (HF), high-sucrose (HSu) or high-fat, high-sucrose (HFHSu) diet for 4 weeks. At euthanasia, blood was collected and the liver was removed for histomorphometrical and molecular analysis. The HF, HSu and HFHSu groups presented glucose intolerance, hepatomegaly, liver steatosis and lipid profile alteration when compared to the SC group (p < 0.0005). Additionally, there was an elevation in protein levels involved in lipogenesis (SREBP-1c), gluconeogenesis (PEPCK and G6Pase) and insulin signaling (IRS-1 and Akt) in the livers from the experimental groups compared to the SC group (p < 0.0005). Thus, we conclude that a short-term HF and/or HSu diet promotes glucose intolerance and liver damage in adult male mice. Surprisingly, the short exposure to excess sucrose in the diet promoted glucose intolerance and liver damage even in the absence of an increase in body mass or changes in serum insulin, cholesterol and triacylglycerol levels.

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“…Previous research in humans (Brons et al 2009; Gardner et al 2007; Harber et al 2005; Mittendorfer and Sidossis 2001; Roberts et al 2008) and rodents (Abumrad et al 1978; Boivin and Deshaies 1995; Cahova et al 2012), comparing the effects of short-term (2 days to 6 weeks) high-fat (HF) diets (40%–60% fat) and low fat (LF) diets (≤35% fat), has demonstrated that HF diets reduce fasting plasma TAG concentrations. These changes occur during energy deficit, energy balance, and energy surplus conditions prior to the development of metabolic disease.…”

Section: Introductionmentioning

confidence: 99%

Differential effects of low-fat and high-fat diets on fed-state hepatic triacylglycerol secretion, hepatic fatty acid profiles, and DGAT-1 protein expression in obese-prone Sprague–Dawley rats

Heden

Morris

Kearney

et al. 2014

Appl. Physiol. Nutr. Metab.

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The purpose of this study was to compare the effects of short-term low-fat (LF) and high-fat (HF) diets on fed-state hepatic triacylglycerol (TAG) secretion, the content of proteins involved in TAG assembly and secretion, fatty acid oxidation (FAO), and the fatty acid profile of stored TAG. Using selectively bred obese-prone Sprague–Dawley rats, we directly measured fed-state hepatic TAG secretion, using Tyloxapol (a lipoprotein lipase inhibitor) and a standardized oral mixed meal (45% carbohydrate, 40% fat, 15% protein) bolus in animals fed a HF or LF diet for 2 weeks, after which the rats were maintained on their respective diet for 1 week (washout) prior to the liver being excised to measure protein content, FAO, and TAG fatty acid profiles. Hepatic DGAT-1 protein expression was ~27% lower in HF- than in LF-fed animals (p < 0.05); the protein expression of all other molecules was similar in the 2 diets. The fed-state hepatic TAG secretion rate was ~39% lower (p < 0.05) in HF- (4.62 ± 0.18 mmol·h−1) than in LF- (7.60 ± 0.57 mmol·h−1) fed animals. Hepatic TAG content was ~2-fold higher (p < 0.05) in HF- (1.07 ± 0.15 nmol·g−1 tissue) than in LF- (0.50 ± 0.16 nmol·g−1 tissue) fed animals. In addition, the fatty acid profile of liver TAG in HF-fed animals closely resembled the diet, whereas in LF-fed animals, the fatty acid profile consisted of mostly de novo synthesized fatty acids. FAO was not altered by diet. LF and HF diets differentially alter fed-state hepatic TAG secretion, hepatic fatty acid profiles, and DGAT-1 protein expression.

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The Opposite Effects of High-Sucrose and High-Fat Diet on Fatty Acid Oxidation and Very Low Density Lipoprotein Secretion in Rat Model of Metabolic Syndrome

Cited by 24 publications

References 32 publications

Nutritional and biochemical effects of aspartame intake in rats under an experimental diet

Nutritional and biochemical effects of aspartame intake in rats under an experimental diet

Short Exposure to a High-Sucrose Diet and the First ‘Hit' of Nonalcoholic Fatty Liver Disease in Mice

Differential effects of low-fat and high-fat diets on fed-state hepatic triacylglycerol secretion, hepatic fatty acid profiles, and DGAT-1 protein expression in obese-prone Sprague–Dawley rats

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