Nutritional and biochemical effects of aspartame intake in rats under an experimental diet

Abstract

The present study evaluates the effect of aspartame intake in rats under a diet mimicking the trends of fat consumption in the society. The composition of the experimental diet was within the recommended human limits except the saturated fat amount supplying from coconut fat. Rats under the experimental diet showed an increase in the body weight, transitory increase in the blood pressure and in plasma values of glucose and triglycerides alongside a transitory reduction in plasma urea versus the standard group. Rats under the experimental diet plus aspartame intake (54.8 ± 7.3 mg/kg bw/day) did not show any increase of body weight and in plasma values of glucose and triglycerides while showed an improvement in the plasma value of urea with respect the group under only the experimental diet. However, the aspartame group showed a more maintained increase of blood pressure. In conclusion, experimental diet produces negative effects on cardiovascular risk factors of the rats while the aspartame intake under the experimental feeding had mixed effects on the cardiometabolic factors of the animals.

Impact of High Aspartame and High Fructose Diet on Vascular Reactivity, Glucose Metabolism and Liver Structure in Diabetic Rats

“…Aspartame with its metabolite methanol could have the same effect of ethanol in the long-term, as ethanol blocks the apical exocytosis of pancreatic acini redirecting it toward the basolateral plasma membrane, causing interstitial pancreatitis, damage to the subcellular membrane, and release of proteolytic enzymes that may lead to auto-digestion [31]. In contrary to that, Martinez-Morales et al [32] found that aspartame administration to experimental diet did not show any increase in blood glucose and TGs level.…”

The Effect of Single Clove Garlic Extract (Allium sativum) Against Aspartame-Induced Hepatotoxicity in Diabetic Rats

“…Harvey's sarcoma of rat viral homozygous h-Ras and viral homologous myeloma c-myc in rat livers [13]. Several clinical disorders, including hepatotoxicity, nephrotoxicity, neurotransmitter imbalance, and cognitive impairment [14]. Measurement of the activities of these marker enzymes in tissues and body fluids can be used to assess the degree of damage and toxicity of a chemical compound on organs/tissues [15,16].…”