Obesity appears to be a dominant condition above inflammation to produce IR in RA patients. The dissociation of the inflammation and obesity components to produce IR suggests the need of an independent therapeutic strategy in obese patients with RA.
The present study evaluates the effect of aspartame intake in rats under a diet mimicking the trends of fat consumption in the society. The composition of the experimental diet was within the recommended human limits except the saturated fat amount supplying from coconut fat. Rats under the experimental diet showed an increase in the body weight, transitory increase in the blood pressure and in plasma values of glucose and triglycerides alongside a transitory reduction in plasma urea versus the standard group. Rats under the experimental diet plus aspartame intake (54.8 ± 7.3 mg/kg bw/day) did not show any increase of body weight and in plasma values of glucose and triglycerides while showed an improvement in the plasma value of urea with respect the group under only the experimental diet. However, the aspartame group showed a more maintained increase of blood pressure. In conclusion, experimental diet produces negative effects on cardiovascular risk factors of the rats while the aspartame intake under the experimental feeding had mixed effects on the cardiometabolic factors of the animals.
Objetivo. Evaluar la capacidad de medidas antropométricas para predecir RI, en una cohorte de mujeres jóvenes sin diabetes. --- Material y métodos. Estudio descriptivo, correlacional y cuantitativo de corte transversal. 60 mujeres universitarias de 17 a 20 años, sin diabetes, sin inflamación sistémica fueron estudiadas, todas las participantes firmaron consentimiento informado. Se obtuvieron 9 medidas antropométricas como: índice de masa corporal (IMC), circunferencia de la cintura (CC) y % de grasa corporal (%GC). Se determinaron las concentraciones plasmáticas de glucosa e insulina en ayuno para calcular el HOMA-IR. --- Resultados. El modelo de regresión lineal paso por paso retuvo solo CC como predictor del HOMA-IR; no retuvo al IMC ni al %GC. El modelo tuvo mayor fuerza predictiva entre los grupos de mujeres con sobrepeso/obesidad que en normopeso. Mediante ROC (receiver operating characteristic curve), mostramos que 81.5 cm de CC tuvo la mayor sensibilidad y especificidad, 80.0% y 82.2% respectivamente. --- Conclusiones. CC es una medida antropométrica poderosa y única para predecir RI, sobretodo, en los grupos de sobrepeso y obesidad; se propone como herramienta de escrutinio de RI. Palabras clave: Antropometría, Obesidad abdominal, Resistencia a la insulina.
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