The old 3-oxoadipate pathway revisited: New insights in the catabolism of aromatics in the saprophytic fungus Aspergillus nidulans

Martins, Tiago M.; Hartmann, Diego O.; Planchon, Sébastien; Martins, Isabel; Renaut, Jenny; Pereira, Cristina Silva

doi:10.1016/j.fgb.2014.11.002

Cited by 40 publications

(71 citation statements)

References 39 publications

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“…The study showed the formation of catechol from salicylate either directly or through 2,3-dihydroxybenzoate. Additionally, the study indicated successive muconate isomerisation reactions in the catechol branch [159].…”

Section: Degradation Pathways In Fungimentioning

confidence: 89%

Diverse Metabolic Capacities of Fungi for Bioremediation

2016

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Bioremediation refers to cost-effective and environment-friendly method for converting the toxic, recalcitrant pollutants into environmentally benign products through the action of various biological treatments. Fungi play a major role in bioremediation owing to their robust morphology and diverse metabolic capacity. The review focuses on different fungal groups from a variety of habitats with their role in bioremediation of different toxic and recalcitrant compounds; persistent organic pollutants, textile dyes, effluents from textile, bleached kraft pulp, leather tanning industries, petroleum, polyaromatic hydrocarbons, pharmaceuticals and personal care products, and pesticides. Bioremediation of toxic organics by fungi is the most sustainable and green route for cleanup of contaminated sites and we discuss the multiple modes employed by fungi for detoxification of different toxic and recalcitrant compounds including prominent fungal enzymes viz., catalases, laccases, peroxidases and cyrochrome P450 monooxygeneses. We have also discussed the recent advances in enzyme engineering and genomics and research being carried out to trace the less understood bioremediation pathways.

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Section: Degradation Pathways In Fungimentioning

confidence: 89%

Diverse Metabolic Capacities of Fungi for Bioremediation

2016

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“…Among the repressed genes were srg1 , the SA marker gene, as well as UMAG_02142 and UMAG_12178 , which encode enzymes predicted to be involved in fungal metabolic pathways. UMAG_02142 displays homologies to muconate cycloisomerases, which are known to act in degradation pathways downstream of catechol (Martins et al ., ). The functional classification system FunCat 2 (Ruepp et al ., ) predicts that UMAG_12178 , the gene with the most severe reduction in transcript levels (Log FC = −2.069), is involved in the metabolism of secondary products derived from tryptophan.…”

Section: Resultsmentioning

confidence: 97%

“…Since many filamentous fungi have evolved ways to eliminate SA (Sze and Dagley, ; Penn and Daniel, ; Rabe et al ., ; Ambrose et al ., ; Martins et al ., ), SA sensing should also be wide spread among these organisms. However, nothing is known about fungal SA perception and signalling.…”

Section: Introductionmentioning

confidence: 99%

Phytohormone sensing in the biotrophic fungus Ustilago maydis – the dual role of the transcription factor Rss1

Rabe

Seitner

Bauer

et al. 2016

Molecular Microbiology

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SummaryThe phenolic compound salicylic acid (SA) is a key signalling molecule regulating local and systemic plant defense responses, mainly against biotrophs. Many microbial organisms, including pathogens, share the ability to degrade SA. However, the mechanism by which they perceive SA is unknown. Here we show that Ustilago maydis, the causal agent of corn smut disease, employs a so far uncharacterized SA sensing mechanism. We identified and characterized the novel SA sensing regulator, Rss1, a binuclear zinc cluster protein with dual functions as putative SA receptor and transcriptional activator regulating genes important for SA and tryptophan degradation. Rss1 represents a major component in the identified SA sensing pathway during the fungus’ saprophytic stage. However, Rss1 does not have a detectable impact on virulence. The data presented in this work indicate that alternative or redundant sensing cascades exist that regulate the expression of SA‐responsive genes in U. maydis during its pathogenic development.

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“…has been reported to have the highest degradative capacity for aromatics (Milstein et al, 1983); however, few studies have examined the fungal biosynthesis of SCFA2-6 using lignin aromatics (Hirose et al, 2013). Martins et al (2015) reported that Aspergillus nidulans biosynthesises acetic acid (C 2 H 4 O 2 ) and succinic acid (C 4 H 6 O 4 ) from benzoic acid, an aromatic compound structurally similar to those present in lignin. However, few studies have reported the concentrations of each of the SCFAs generated.…”

Section: Introductionmentioning

confidence: 99%

“…Depolymerised lignin forms a wide range of aromatics that are gradually oxidised until two basic types are formed: catechol and protocatechuic acid (Martins et al, 2015). (4) Cleavage of aromatic rings by monooxygenases and cytochrome P450 (Prenafeta-Boldú et al, 2006).…”

Section: Introductionmentioning

confidence: 99%