Production of short-chain fatty acids from the biodegradation of wheat straw lignin by Aspergillus fumigatus

Baltierra-Trejo, Eduardo; Sanchez–Yáñez, Juan Manuel; Buenrostro-Delgado, Otoniel; Márquez-Benavides, Liliana

doi:10.1016/j.biortech.2015.07.105

Cited by 25 publications

(12 citation statements)

References 29 publications

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“…Previously, Aspergillus was found to negatively correlate with SCFAs in subjects on a carbohydrate-rich diet [61]. However, a recent study showed that Aspergillus species are capable of producing SCFAs metabolites from fibre rich diet substances [62]. No significant correlations between Penicillium abundance and any of the metabolites were identified.…”

Section: Discussionmentioning

confidence: 99%

Gut Mycobiome Dysbiosis is Linked to Hypertriglyceridemia Among Home Dwelling Elderly Danes

Ahmad

Castro‐Mejía

Krych

et al. 2020

Preprint

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24 25 26 Email addresses: 27 HFA fauzanahmad@ump.edu.my 28 JLC jcame@food.ku.dk 29 ŁK krych@food.ku.dk 30 BK bzo@food.ku.dk 31 WK wk@envs.au.dk 32 RLB r.bechshoeft@gmail.com 33 SR s.reitelseder@gmail.com 34 GWH grith.westergaard.hoejfeldt.01@regionh.dk 35 SBE se@food.ku.dk 36 LH l.holm@bham.ac.uk 37 KF karoline.faust@kuleuven.be 38 DSN dn@food.ku.dk 39 40 41 42 43 44 45 ABSTRACT 46 Gut microbial dysbiosis have been in the etiology of a number of diseases, yet 47 the presence of fungal communities and their possible association with host health are 48 little understood. This study attempts to identify gut microbial fungal associations 49 with the progression of atherogenic dyslipidemia in a population of older adults by 50 investigating the interplay between dietary intake, gut mycobiome composition, 51 plasma and fecal metabolome and anthropometric/body-composition measurements of 52 100 Danes aged 65 to 81 (69.57  3.64) years. The gut mycobiome composition were 53 determined by high-throughput sequencing of internal transcribed spacer (ITS2) gene 54 amplicons, while the plasma and fecal metabolome was determined by GC-TOF-MS. 55 The gut microbiome of the subjects investigated is home to three main eukaryotic 56 phyla, namely Ascomycota, Basidiomycota and Zygomycota, with genera 57 Penicillium, Candida, and Aspergillus being particularly common. 58 Hypertriglyceridemia was associated with fewer observed fungal species, and Bray-59 Curtis dissimilarity matrix-based analysis showed significant (P<0.05) clustering 60 according to fasting levels of circulating plasma triglycerides (Tg) and very low-61 density lipoprotein (VLDL) cholesterol fasting levels, respectively. Interestingly, 62 neither hypertriglyceridemia nor elevated VLDL levels were reflected in the 63 prokaryotic component of the gut microbiome as determined by 16S rRNA gene 64 amplicon sequencing. Higher levels of Tg and VLDL cholesterol significantly 65 associates with increased relative abundance of genus Penicillium, possibly mediated 66 by a higher dietary fat intake (ANOVA, P<0.05), and Aspergillus and Guehomyces 67 were positively associated with SCFAs groups. Collectively, these findings suggest 68 that in older adults' gut mycobiome dysbiosis is associated with hypertriglyceridemia, 69 a known risk factor for development of cardiovascular disease. 70 71 Keywords: older-adults, hypertriglyceridemia, dysbiosis, gut mycobiome, host 72 metabolome, triglyceride, VLDL and dietary fat intake 73 74 75 93 dyslipidaemia in both men and women older than 65 years, as compared to younger 94 individuals [16]. Further, elevated triglycerides (Tg) and very low density level 95 (VLDL) cholesterol levels have been associated with subclinical atherosclerosis and 96 dubbed as independent risk factors for CVD [17]. Several large studies suggest that 97 hypertriglyceridemia is related to increased levels of remnant lipoproteins in 98 promoting atherogenesis [18], [19]. The possible mechanisms for this association 99 include excessive free fatty acid release, product...

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Section: Discussionmentioning

confidence: 99%

Gut Mycobiome Dysbiosis is Linked to Hypertriglyceridemia Among Home Dwelling Elderly Danes

Ahmad

Castro‐Mejía

Krych

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…Commensal fungi seem to reinforce bacterial protective benefits on both local and systemic immunity, with a specific role for mannans, a highly conserved fungal wall component. Moreover, fungi are able to produce SCFAs (Baltierra-Trejo et al, 2015;Xiros et al, 2019). Therefore, gut mycobiota perturbations could be as deleterious as bacteriobiota ones (Wheeler et al, 2016;Jiang et al, 2017).…”

Section: Gut Microbiota and Local Immunitymentioning

confidence: 99%

“…SCFA receptor-deficient mice show increased inflammatory responses in experimental models of asthma . Fungi, including A. fumigatus, can also produce SCFAs or create a biofilm enhancing the bacterial production of SCFAs, but on the other hand, bacterial SCFAs can dampen fungal growth (Hynes et al, 2008;Baltierra-Trejo et al, 2015;Xiros et al, 2019). The impact of fungal production of SCFAs on the host has not been assessed so far.…”

Section: Long-reaching Immune Modulation Within the Gut-lung Axismentioning

confidence: 99%

The Gut-Lung Axis in Health and Respiratory Diseases: A Place for Inter-Organ and Inter-Kingdom Crosstalks

Enaud

Prével

Ciarlo

et al. 2020

Front. Cell. Infect. Microbiol.

457

411

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The gut and lungs are anatomically distinct, but potential anatomic communications and complex pathways involving their respective microbiota have reinforced the existence of a gut-lung axis (GLA). Compared to the better-studied gut microbiota, the lung microbiota, only considered in recent years, represents a more discreet part of the whole microbiota associated to human hosts. While the vast majority of studies focused on the bacterial component of the microbiota in healthy and pathological conditions, recent works have highlighted the contribution of fungal and viral kingdoms at both digestive and respiratory levels. Moreover, growing evidence indicates the key role of inter-kingdom crosstalks in maintaining host homeostasis and in disease evolution. In fact, the recently emerged GLA concept involves host-microbe as well as microbe-microbe interactions, based both on localized and long-reaching effects. GLA can shape immune responses and interfere with the course of respiratory diseases. In this review, we aim to analyze how the lung and gut microbiota influence each other and may impact on respiratory diseases. Due to the limited knowledge on the human virobiota, we focused on gut and lung bacteriobiota and mycobiota, with a specific attention on inter-kingdom microbial crosstalks which are able to shape local or long-reached host responses within the GLA.

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“…FAS has been described from a variety of yeasts and fungi, such as S. cerevisiae , C. albicans , other Candida species, Cryptococcus neoformans , and Penicillium species [ 80 ]. As fungi such as S. cerevisiae or even Aspergillus fumigatus are also able to produce short-chain fatty acids [ 81 ], we can reasonably hypothesize that the gut mycobiome could use the same pathway; however, no study has explored this hypothesis.…”

Section: Mycobiome-gut-brain Axis (Gba): Current Evidence From Digmentioning

confidence: 99%

The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis

et al. 2018

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In recent years, the gut microbiota has been considered as a full-fledged actor of the gut–brain axis, making it possible to take a new step in understanding the pathophysiology of both neurological and psychiatric diseases. However, most of the studies have been devoted to gut bacterial microbiota, forgetting the non-negligible fungal flora. In this review, we expose how the role of the fungal component in the microbiota-gut-brain axis is legitimate, through its interactions with both the host, especially with the immune system, and the gut bacteria. We also discuss published data that already attest to a role of the mycobiome in the microbiota-gut-brain axis, and the impact of fungi on clinical and therapeutic research.

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Production of short-chain fatty acids from the biodegradation of wheat straw lignin by Aspergillus fumigatus

Cited by 25 publications

References 29 publications

Gut Mycobiome Dysbiosis is Linked to Hypertriglyceridemia Among Home Dwelling Elderly Danes

Gut Mycobiome Dysbiosis is Linked to Hypertriglyceridemia Among Home Dwelling Elderly Danes

The Gut-Lung Axis in Health and Respiratory Diseases: A Place for Inter-Organ and Inter-Kingdom Crosstalks

The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis

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