The Nerve Fiber as a System in Continuous Flow: Microcinematographic and Electronmicroscopic Demonstrations

Weiß, Paul; Ac, Taylor; Pa, Pillai

doi:10.1126/science.136.3513.330

Cited by 73 publications

(7 citation statements)

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“…This pumping action could serve to propel axoplasm distally from the neuronal cell body to the periphery. The observations (Weiss, Taylor & Pillai, 1962) of peristaltic waves in myelinated sensory fibres in vitro lend support to this hypothesis. Alternatively, the contractile Schwann cells may influence fluid flow within the endoneurial spaces.…”

Section: Discussionsupporting

confidence: 60%

Pulsatile and myelin‐forming activities of Schwann cells in vitro

Ernyei¹,

Young²

1966

The Journal of Physiology

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SUMMARY1. Sympathetic and dorsal root ganglia from young mice and new-born rats were cultured in vitro. The activity of the outgrowing Schwann cells was studied with time-lapse photography.2. Schwann cells exhibited a pulsatile activity with a contraction rate varying from 1 to 12 min. The occurrence of pulsations depended on the mode of attachment of cells to their surroundings.3. Fibres of various materials were introduced into the cultures in an attempt to simulate conditions obtaining in vivo. Schwann cells attached themselves to these fibres and rotated about them depositing myelin. Polarized light and histochemical studies showed that myelin was formed as early as four days in vitro.4. The possible significance of the behaviour of Schwann cells in vitro is discussed.

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Section: Discussionsupporting

confidence: 60%

Pulsatile and myelin‐forming activities of Schwann cells in vitro

Ernyei¹,

Young²

1966

The Journal of Physiology

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“…The phenomenon ofaxoplasmic transport, (Taylor and Weiss 1965, Weiss and Holland 1967a, b, Mc Ewen and Grafstein 1968, Karlsson and Sjostrand 1968, Sjostrand and Karlsson 1969, Chou 1970, raises the question how the transported material passes the narrow crowded nodal axon. As proposed by Weiss et al (1962) and Grafstein et al (1970) the neurotubules represent a possible transport route.…”

Section: Discussionmentioning

confidence: 94%

Ultrastructural and light‐microscopic studies of the nodal region in large myelinated fibres of the adult feline spinal cord white matter

Hildebrand¹

1971

Acta Physiologica Scandinavica

118

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“…They merely support the view that some mechanism for transport of material is available in the peripheral nerve stump during some time after denervation. Local mechanisms for transport in axons have been discussed by Weiss and co-worker (Weiss & Hiscoe, 1948;Weiss, 1961Weiss, , 1963Weiss, Taylor & Pillai, 1962), by Ernyei & Young (1966) and by Schmitt (1968). Ochs & Ranish (1969 have demonstrated that labelled material can move from a ligature on a nerve in a proximo-distal course.…”

Section: Discussionmentioning

confidence: 99%

Movement of choline acetyltransferase in axons disconnected from their cell bodies

Ekström¹,

Emmelin²

1971

The Journal of Physiology

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SUMMARY1. Phrenic nerves of rats were cut out and divided into two parts of equal length, one proximal and one distal. The activity of choline acetyltransferase of the two pieces was estimated. Four groups of rats were studied: (1) normal rats, and rats in which 3 days earlier, (2) the right nerve had been cut in the uppermost part of the thorax, (3) a ligature had been tied round the right nerve just above the diaphragm, and (4) these two procedures had been combined.2. In normal rats the activity of the enzyme was about the same in proximal and distal pieces. Ligation of the nerve caused an increase of the activity, of about 50 %, in the distal but not in the proximal segment.3. After section of the nerve the activity below the section was 18 % of normal in the proximal, and 9 % in the distal piece.4. When the nerve was both cut and tied the activity decreased to the same level in both pieces, and this was about the level of the proximal piece after mere section of the nerve.5. It is concluded that choline acetyltransferase can move for some time along the axons to the nerve terminals even when the connexion with the soma has been interrupted.

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The Nerve Fiber as a System in Continuous Flow: Microcinematographic and Electronmicroscopic Demonstrations

Cited by 73 publications

References 0 publications

Pulsatile and myelin‐forming activities of Schwann cells in vitro

Pulsatile and myelin‐forming activities of Schwann cells in vitro

Ultrastructural and light‐microscopic studies of the nodal region in large myelinated fibres of the adult feline spinal cord white matter

Movement of choline acetyltransferase in axons disconnected from their cell bodies

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