The Mont Park Survey for Ocular Changes in Chlorpromazine Therapy

Galbraith, J. E. K.; Gibson, Blake; Crock, G. W.; Pearce, Terri A.

doi:10.5694/j.1326-5377.1966.tb72520.x

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1966

1988

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Cited by 5 publications

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“…Women, possibly because of estrogen-enhanced melanosis (2), and people with light brown hair (5) may be more susceptible. While some authors (1,4) suggest that chronic therapy with daily dosages of 500 mg or more is necessary for pigmentation, others (7,8) report pigmentation at much lower doses, which refutes the theory of a threshold dosage for induction of skin pigmentation. Pigment produced in the skin is transported to the blood stream by inflammatory cells and deposited throughout the body, causing a generalized melanosis of the viscera (5).…”

Section: Discussionmentioning

confidence: 99%