Effects of prolonged phenothiazine intake on psychotic and other hospitalized children

Mcandrew, John; Case, Quentin; Treffert, Darold A.

doi:10.1007/bf01537628

Cited by 75 publications

(11 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…TD has been reported in children and adolescents, but adequate epidemiological studies are few [31]. Rates of withdrawal‐emergent dyskinesia of 8%[32] and 51%[33] have been reported in two studies of children on long‐term neuroleptics. High rates have almost invariably been reported in elderly patients on neuroleptics [34,35].…”

Section: Epidemiologymentioning

confidence: 99%

The current status of tardive dyskinesia

Sachdev

2000

Aust N Z J Psychiatry

View full text Add to dashboard Cite

show abstract

Section: Epidemiologymentioning

confidence: 99%

The current status of tardive dyskinesia

Sachdev

2000

Aust N Z J Psychiatry

View full text Add to dashboard Cite

show abstract

“…Since pharmacotherapy with dextroamphetamine, mctliylphenidatc, and imipramine is frequently ineffective, and sinee the neuro-Icptics (e.g. phenothiazines and butyrophcnones) are associated with dyskincsias (McAndrew et al, 1972; PoHzos et aL, 1973) and other potentially noxious side effects (Winsberg et al, 1976), alternative drugs are clearly needed.In our ongoing clinical work, another tricyclic, amitriptyline, has been useful for some of these children. There is also research evidence which points to the potential utility of this compound in treating children with behavior disorders.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

Amitriptyline and Methylphenidate Treatment of Behaviorally Disordered Children

Yepes

Balka

Winsberg

et al. 1977

Child Psychology Psychiatry

View full text Add to dashboard Cite

THIS STUDY is one in a series of continuing investigations Winsberg et aL, 1974b) which seeks to determine the relative effectiveness of various psychotropic drugs in controlling hyperactive/aggressive behaviors among children.In our previous work, we found the psychostimulants (dextroamphetamine and methylphenidate) to be comparable in effectiveness for the treatment of such behavior disorders (Winsberg et al., 1974b), while the tricyclic compound, imipramine, was also found to be effective in a study which compared it to dextroamphetamine . The findings from this research were consistent with our clinical experience in showing that many children fail to respond to each of these medications. Since pharmacotherapy with dextroamphetamine, mctliylphenidatc, and imipramine is frequently ineffective, and sinee the neuroIcptics (e.g. phenothiazines and butyrophcnones) are associated with dyskincsias (McAndrew et al., 1972; PoHzos et aL, 1973) and other potentially noxious side effects (Winsberg et al., 1976), alternative drugs are clearly needed.In our ongoing clinical work, another tricyclic, amitriptyline, has been useful for some of these children. There is also research evidence which points to the potential utility of this compound in treating children with behavior disorders. Kraft et al. (1966) in a noncontroUed study, found amitriptyline to be effective in 60% of outpatient children with different psychiatric problems. Krakowski (1965) studied 50 hyperkinetic children whose diagnoses included: neurosis, psychophysiological disorders, mental deficiency, schizophrenia, neurotic traits, and habit and conduct disorders. Sixty per cent ofthe children with the diagnosis of conduct disorders were reported to have a good or excellent response to amitriptyline therapy. However, a major weakness of that study was that the prime behavioral dependent measure was a subjective clinical evaluation. Lucas et al. (1965), in a double-blind study, used amitriptyline for childhood depressions and found that the behavior category in w hich the greatest number of patients improved was that which the authors termed "problems of external control." The latter report does not allow for a more precise categorization of the subjects' behavior problems.

show abstract

“…However, such a statement is only partially true. McAndrews (1972) found that drug-induced dyskinesia in children improved following drug withdrawal. Degkwitz (1969) reported that about 50% of his T.D.…”

Section: Is Td Reversible?mentioning

confidence: 99%

Drug Induced Dyskinesia: A Critical Review

Ananth¹

1979

Int Pharmacopsychiatry

View full text Add to dashboard Cite

Tardive dyskinesia (TD) has been reported to occur after the long term administration of neuroleptics. Its prevalence has been reported to vary from 0.5-56%. However, no clear relationship is established between a particular neuroleptic, its dosage and duration of administration and the diagnosis and occurrence of TD. Neuropathological investigations have not provided any definitive lessons. In addition, TD can be produced by a number of drugs of different chemical classes. Similarly, the evidence for dopaminergic hypersensitivity is equivocal. The only definitive feature seems to be an individual predisposition, the nature of which needs to be elucidated. Of course, basic to any future research into new insights regarding etiology, the fundamental problem of definition and identification based on the accepted definition are most essential. This solid foundation is necessary for the resolution of any conflicting results that may be reported in the future.

show abstract

Effects of prolonged phenothiazine intake on psychotic and other hospitalized children

Cited by 75 publications

References 29 publications

The current status of tardive dyskinesia

The current status of tardive dyskinesia

Amitriptyline and Methylphenidate Treatment of Behaviorally Disordered Children

Drug Induced Dyskinesia: A Critical Review

Contact Info

Product

Resources

About