Resolution of chlorpromazine‐induced pigmentation with haloperidol substitution

Thompson, Travis; Lal, Samarthji; Yassa, Ramzy; Gerstein, William

doi:10.1111/j.1600-0447.1988.tb06416.x

Cited by 9 publications

(3 citation statements)

References 8 publications

(7 reference statements)

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“…Its limited reversibility led to attempts to treat the syndrome with depigmenting agents D-penicillamine and ascorbic acid, although the latter was not effective (Gibbard and Lehmann 1966). Alternatively, the pigmentary changes were dealt with by substituting different antipsychotic medications (Ewing and Einarson 1981; Thompson et al 1988; Lal et al 1993). Several pathophysiological mechanisms may be responsible for this condition: An inflammatory response to chlorpromazine might cause increased melanin deposition, potentially a direct cause of change in skin color.…”

Section: Nonneurological Side Effectsmentioning

confidence: 99%

Neuroleptic Intolerance

Hansen

Casey

Hoffman

1997

Schizophrenia Bulletin

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This article reviews antipsychotic medication side effects, especially those that require the physician to discontinue or the patient to be noncompliant with otherwise useful medication. They include such common problems as extrapyramidal syndromes (dystonia, akathisia, drug-induced Parkinsonism, tardive dyskinesia), sedation, weight gain, and sexual dysfunction, as well as less frequent concerns, such as seizures, neuroleptic malignant syndrome, agranulocytosis, torsade de pointes, hepatitis, and dermatological and ophthalmological syndrome. The adverse events associated with some of the new antipsychotic drugs are included. Available information about individual susceptibility to side effects is addressed by syndrome.

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Section: Nonneurological Side Effectsmentioning

confidence: 99%

Neuroleptic Intolerance

Hansen

Casey

Hoffman

1997

Schizophrenia Bulletin

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“…Black galactorrhoea secondary to phenothiazines has also been reported 83 . In the case of chlorpromazine hyperpigmentation, it appears that the pigmentation generally reverses within months to years of discontinuing therapy, the use of other neuroleptics, including other phenothiazines, does not cause pigment disorders, and that lenticular changes persist, whereas corneal changes may slowly resolve 84–86 …”

Section: Other Adverse Cutaneous Reactionsmentioning

confidence: 99%

Psychoactive drugs and skin

Hautmann

Lotti

2003

Acad Dermatol Venereol

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“…1,4 Rather, on the contrary, one study reported this drug to be a suitable alternative to chlorpromazine in patients with chlorpromazine-induced cutaneous pigmentation. 5 We can hypothesize that haloperidol-induced hyperpigmentation in our patients may be mediated by its effect on dopaminergic receptors. Even though the exact action of dopamine (DA) receptors is yet to be verified at the molecular and genetic level, ample literature remains supportive of the fact that D2 dopamine receptor (DRD2) activation inhibits melanogenesis, whereas DRD4 activation promotes it.…”

mentioning

confidence: 99%