The lipid and clinical effects of sequential transdermal estradiol and estradiol/norethisterone acetate in 674 women

Abstract

Transdermal administration of E(2) and sequential NETA for a period of 48 weeks (twelve 28-day cycles) was associated with beneficial changes, albeit of differing magnitudes, in the concentration of total cholesterol, LDL-C and triglycerides. This protective lipid profile, together with satisfactory clinical efficacy and acceptable safety and compliance, makes this system a good alternative in hormone replacement therapy.

Do different delivery systems of estrogen therapy influence serum lipids differently in surgically menopausal women?

“…In the present study, all ET modalities caused a significant decline in t‐Chol levels starting from the sixth month. The results with the oral and transdermal routes are in accordance with previous reports 12–14 . However, contrary to the present results, 6 months of intranasal therapy has been reported to have no effect on t‐Chol 15 .…”

LycoRed as an alternative to hormone replacement therapy in lowering serum lipids and oxidative stress markers: A randomized controlled clinical trial

“…25,27,29 Serum triglycerides have been found to be increased with oral and decreased with transdermal estrogen therapy. 28,29 In our present study, we observed a significant fall in TC and LDL, and an increase in HDL and TG in both the continuous combined HRT and the LycoRed group. The oxidative stress markers also showed a positive change, which was similar in both the groups.…”

“…24 Reduction in the serum TC and LDL has been reported in patients receiving unopposed or combined HRT, both by oral and parentral route. [25][26][27][28] However, the data on other lipids is less consistent with studies showing an increase, decrease or no change in HDL levels. 25,27,29 Serum triglycerides have been found to be increased with oral and decreased with transdermal estrogen therapy.…”

“…reported a favorable effect of olive oil and tomato lycopene on the lipid profile in healthy individuals, although the mechanism was not clear 24 . Reduction in the serum TC and LDL has been reported in patients receiving unopposed or combined HRT, both by oral and parentral route 25–28 . However, the data on other lipids is less consistent with studies showing an increase, decrease or no change in HDL levels.…”

“…However, the data on other lipids is less consistent with studies showing an increase, decrease or no change in HDL levels. 25,27 , 29 Serum triglycerides have been found to be increased with oral and decreased with transdermal estrogen therapy 28,29 …”