The lignicolous fungus <i>Trametes versicolor</i> (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents

Janjušević, Ljiljana; Karaman, Maja; Šibul, Filip; Tommonaro, Giuseppina; Iodice, Carmine; Jakovljević, Dragica; Pejin, Boris

doi:10.1080/14756366.2016.1252759

Cited by 64 publications

(68 citation statements)

References 47 publications

(75 reference statements)

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“…The obtained results demonstrate the antioxidative nature of the aqueous leaf extract of C. aconitifoliu s in the management of type II diabetes mellitus. Also, the scavenging abilities of this extract against all the tested free radical may be associated with the presence of both total phenol and flavonoid, which support the claim of Janjušević et al () as well as Glumac, Pejin, Karaman, Mojović, and Matavulj ().…”

Section: Discussionsupporting

confidence: 85%

Cnidoscolus aconitifolius(Mill.) I. M. Johnst leaf extract prevents oxidative hepatic injury and improves muscle glucose uptake ex vivo

et al. 2019

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Total phenol, total flavonoid, and ameliorative potentials of aqueous leaf extract of Cnidoscolus aconitifolius in Fe2+‐induced oxidative stress in hepatic tissue and muscle glucose uptake using ex vivo models were assessed. These were carried out using standard procedures. The results revealed that the extract showed the presence of total phenol and total flavonoid, as well as free radicals scavenging abilities in a dose‐dependent manner. Also, the aqueous leaf extract of C. aconitifolius enhanced Fe2+‐induced oxidative injury in hepatic tissue by considerably reducing the concentration of lipid peroxidation, with improvement in the activities of catalase and superoxide dismutase in a dose‐dependent manner. In addition, the extract enhanced glucose uptake in psoas muscle. It can be deduced from this study that the extract might be beneficial to people with diabetes mellitus. Practical applications Aqueous leaf extract of Cnidoscolus aconitifolius displayed the presence of total phenol and total flavonoid, as well as an increase in free radical scavenging activities in a dose‐dependent manner. The plant extract also improved Fe2+‐induced oxidative injury in hepatic tissue by decreasing lipid peroxidation concentration, improved the activities of catalase as well as superoxide dismutase, with enhancement in glucose uptake of psoas muscle in a dose‐dependent manner.

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Section: Discussionsupporting

confidence: 85%

Cnidoscolus aconitifolius(Mill.) I. M. Johnst leaf extract prevents oxidative hepatic injury and improves muscle glucose uptake ex vivo

et al. 2019

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“…Interestingly, these flavonoids were recently detected by mass spectrometry in T. versicolor fructifications. Their presence might arise from trees or soils on which the fungi grow 29 .…”

Section: Resultsmentioning

confidence: 99%

Molecular recognition of wood polyphenols by phase II detoxification enzymes of the white rot Trametes versicolor

Schwartz

Perrot

Aubert

et al. 2018

Sci Rep

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Wood decay fungi have complex detoxification systems that enable them to cope with secondary metabolites produced by plants. Although the number of genes encoding for glutathione transferases is especially expanded in lignolytic fungi, little is known about their target molecules. In this study, by combining biochemical, enzymatic and structural approaches, interactions between polyphenols and six glutathione transferases from the white-rot fungus Trametes versicolor have been demonstrated. Two isoforms, named TvGSTO3S and TvGSTO6S have been deeply studied at the structural level. Each isoform shows two distinct ligand-binding sites, a narrow L-site at the dimer interface and a peculiar deep hydrophobic H-site. In TvGSTO3S, the latter appears optimized for aromatic ligand binding such as hydroxybenzophenones. Affinity crystallography revealed that this H-site retains the flavonoid dihydrowogonin from a partially purified wild-cherry extract. Besides, TvGSTO6S binds two molecules of the flavonoid naringenin in the L-site. These data suggest that TvGSTO isoforms could interact with plant polyphenols released during wood degradation.

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“…In addition, many exhibit pharmacological activities with few side effects and are used as medicinal agents. Encouragingly, many fungal species have been reported to display neuroprotective properties in the context of neurodegenerative diseases [ 7 ]. Our group found that a polysaccharide isolated from Sparassis crispa protected PC12 cells against L-glutamic acid- (L-Glu-) induced apoptosis via the mitochondrial apoptotic pathway [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Basis for Use of Armillaria mellea Polysaccharides in Alzheimer’s Disease: Antiapoptosis and Antioxidation

Lü

Zhang

et al. 2017

Oxidative Medicine and Cellular Longevity

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Armillaria mellea, an edible fungus, exhibits various pharmacological activities, including antioxidant and antiapoptotic properties. However, the effects of A. mellea on Alzheimer's disease (AD) have not been systemically reported. The present study aimed to explore the protective effects of mycelium polysaccharides (AMPS) obtained from A. mellea, especially AMPSc via 70% ethanol precipitation in a L-glutamic acid- (L-Glu-) induced HT22 cell apoptosis model and an AlCl3 plus D-galactose- (D-gal-) induced AD mouse model. AMPSc significantly enhanced cell viability, suppressed nuclear apoptosis, inhibited intracellular reactive oxygen species accumulation, prevented caspase-3 activation, and restored mitochondrial membrane potential (MMP). In AD mice, AMPSc enhanced horizontal movements in an autonomic activity test, improved endurance times in a rotarod test, and decreased escape latency time in a water maze test. Furthermore, AMPSc reduced the apoptosis rate, amyloid beta (Aβ) deposition, oxidative damage, and p-Tau aggregations in the AD mouse hippocampus. The central cholinergic system functions in AD mice improved after a 4-week course of AMPSc administration, as indicated by enhanced acetylcholine (Ach) and choline acetyltransferase (ChAT) concentrations, and reduced acetylcholine esterase (AchE) levels in serum and hypothalamus. Our findings provide experimental evidence suggesting A. mellea as a neuroprotective candidate for treating or preventing neurodegenerative diseases.

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The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents

Cited by 64 publications

References 47 publications

Cnidoscolus aconitifolius(Mill.) I. M. Johnst leaf extract prevents oxidative hepatic injury and improves muscle glucose uptake ex vivo

Cnidoscolus aconitifolius(Mill.) I. M. Johnst leaf extract prevents oxidative hepatic injury and improves muscle glucose uptake ex vivo

Molecular recognition of wood polyphenols by phase II detoxification enzymes of the white rot Trametes versicolor

Pharmacological Basis for Use of Armillaria mellea Polysaccharides in Alzheimer’s Disease: Antiapoptosis and Antioxidation

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